Registration Dossier
Registration Dossier
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EC number: 203-804-1 | CAS number: 110-80-5
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable publication
Data source
Reference
- Reference Type:
- publication
- Title:
- The results of microbial mutation test for forty-three industrial chemicals
- Author:
- Shimizu et al..
- Year:
- 1 985
- Bibliographic source:
- Jpn. J. Ind. Health 27, 400-419
Materials and methods
- Principles of method if other than guideline:
- Method: other: similar to OECD Guideline 471
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2-ethoxyethanol
- EC Number:
- 203-804-1
- EC Name:
- 2-ethoxyethanol
- Cas Number:
- 110-80-5
- Molecular formula:
- C4H10O2
- IUPAC Name:
- 2-ethoxyethanol
- Details on test material:
- purity in all test = 98 %
Name of test substance as stated in publication: 2-Ethoxyethanol
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 from liver of male Sprague-Dawley rats
- Test concentrations with justification for top dose:
- 5, 10, 50, 10, 500, 1000, 5000 µg/plate
Controlsopen allclose all
- Positive controls:
- yes
- Positive control substance:
- benzo(a)pyrene
- Positive controls:
- yes
- Positive control substance:
- 9-aminoacridine
- Positive controls:
- yes
- Positive control substance:
- N-ethyl-N-nitro-N-nitrosoguanidine
- Positive controls:
- yes
- Positive control substance:
- 4-nitroquinoline-N-oxide
- Positive controls:
- yes
- Positive control substance:
- 2-nitrofluorene
- Positive controls:
- yes
- Positive control substance:
- other: 2-aminoanthracene
- Positive controls:
- yes
- Positive control substance:
- furylfuramide
- Details on test system and experimental conditions:
- OTHER: Ames Test
Results and discussion
Test results
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Remarks on result:
- other: other: Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538; Escherichia coli WP2uvrA
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- According to the results in this gene mutation assay the test substance 2-ethoxyethanol was not mutagenic to the microbial strains of Salmonella typhimurium (TA 98, TA 100, TA 1535, TA 1537, TA 1538) and Escherichia coli (WP2uvrA).
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