Registration Dossier
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EC number: 203-804-1 | CAS number: 110-80-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: publication of acceptable quality standard
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals.
- Author:
- Galloway SM, Armstrong MJ, Reuben C, Colman S, Brown B, Cannon C, Bloom AD, Nakamura F, Ahmed M, Duk S, Rimpo J, Margolin BH, Resnick MA, Anderson B
- Year:
- 1 987
- Bibliographic source:
- Environ Molec Mutag 10, 1-175
- Reference Type:
- publication
- Title:
- Development of a standard protocol for in vitro cytogenetic testing with Chinese hamster ovary cells: Comparison of results for 22 compounds in two laboratories.
- Author:
- Galloway et al.
- Year:
- 1 985
- Bibliographic source:
- Galloway SM, Bloom AD, Resnick M, Margolin BH, Nakamura F, Archer P, Zeiger E (1985), Environ Mutagen 7: 1-51
Materials and methods
- Principles of method if other than guideline:
- Method: described in detail in Galloway et al. (1985), see reference above. According to a previous IUCLID dossier from 2008 (author unknown), the method would be similar to OECD TG 473.
- GLP compliance:
- not specified
- Type of assay:
- other: in vitro mammalian sister chromatid exchange, in vitro mammalian chromosome aberration
Test material
- Reference substance name:
- 2-ethoxyethanol
- EC Number:
- 203-804-1
- EC Name:
- 2-ethoxyethanol
- Cas Number:
- 110-80-5
- Molecular formula:
- C4H10O2
- IUPAC Name:
- 2-ethoxyethanol
- Details on test material:
- Name of the test substance as stated in the publication: 2-ethoxyethanol
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: cloned Chinese hamster ovary cells (CHO-W-B1)
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 liver homogenate from male Sprague-Dawley rats
- Test concentrations with justification for top dose:
- Sister chromatid exchange (SCE): 951-9510 µg/mL (+/- S9 mix)
Chromosome aberration (ABS): 4780-9510 µg/mL (+/- S9 mix)
Results and discussion
Test resultsopen allclose all
- Species / strain:
- Chinese hamster Ovary (CHO)
- Metabolic activation:
- with and without
- Genotoxicity:
- positive
- Remarks:
- SCE: stronger response without than with S9
- Cytotoxicity / choice of top concentrations:
- other: no information was given
- Species / strain:
- Chinese hamster Ovary (CHO)
- Metabolic activation:
- with and without
- Genotoxicity:
- positive
- Remarks:
- chromosome aberration without S9
- Cytotoxicity / choice of top concentrations:
- other: no information was given
- Species / strain:
- Chinese hamster Ovary (CHO)
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Remarks:
- chromosome aberration with S9
- Cytotoxicity / choice of top concentrations:
- other: no information was given
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
other: SCE positive; ABS positive without metabolic activation, negative with metabolic activation
The test substance 2-ethoxyethanol showed a positive response in the sister chromatid exchange assay and in the chromosome aberration assay of cloned chinese hamster ovary cells (CGO-W-B1). Aberrations were only induced without the metabolic activation (S9 liver homogenate from male Sprague-Dawley rats), whereas SCEs were observed with and without the metabolic activation.
The test results point to in vitro mutagenicity of the test substance under the test conditions.
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