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Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication

Data source

Reference
Reference Type:
publication
Title:
Respiratory uptake and elimination of ethylene glycol monoethyl ether after experimental human exposure
Author:
Groeseneken D, Veulemans H, Masschelein R
Year:
1986
Bibliographic source:
Br. J. Ind. Med. 43: 544-549

Materials and methods

Type of study / information:
Type of data: Human
Principles of method if other than guideline:
Method: other: exposure to test substance under various conditions of exposure concentration and physical workload
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name of the test substance as stated in the publication: ethylene glycol monoethyl ether (EGEE)

Results and discussion

Any other information on results incl. tables

Absorption and exposure concentration:

Under resting conditions, an average of 64% of inhaled 2 -ethoxyethanol was retained. R(E) and Cl(atm) remained unchanged as exposure concentration increased. The absorbed dose was apparently proportional to the inhaled concentration and a linear relation between uptake rate and exposure concentration was observed.

Absorption and physical exercise:

Cl(atm) and consequently rate of uptake increased when physical exercise was performed during exposure. This was due not only to an increase in the pulmonary ventilation rate but also to a slight increase in retention. The increase of R(E), however, was not proportional to the level of exercise since no difference was found between 30W and 60W.

Individual respiratory uptake of 2 -ethoxyethanol was governed mainly by pulmonary ventilation, corrected for respiratory frequency, and the concentration of the test substance in the air.

Respiratory elimination and exposure concentration:

The postexposure breath concentration of 2 -ethoxyethanol was measured at regular times for four hours after the exposure period. Exhaled concentrations declined quickly during the first minutes, since the concentration after 7.5 minutes was only 1.5 + 0.6 % of the exhaled concentration during exposure. Thereafter a much slower decrease was observed to levels near the detection limit of the method. Postexposure breath concentrations were higher as exposure concentration and consequently uptake increased.

Postexposure breath concentrations tended to be higher as the physical workload increased but this tendency was not significant.

Applicant's summary and conclusion