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EC number: 203-804-1 | CAS number: 110-80-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Respiratory uptake and elimination of ethylene glycol monoethyl ether after experimental human exposure
- Author:
- Groeseneken D, Veulemans H, Masschelein R
- Year:
- 1 986
- Bibliographic source:
- Br. J. Ind. Med. 43: 544-549
Materials and methods
- Type of study / information:
- Type of data: Human
- Principles of method if other than guideline:
- Method: other: exposure to test substance under various conditions of exposure concentration and physical workload
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-ethoxyethanol
- EC Number:
- 203-804-1
- EC Name:
- 2-ethoxyethanol
- Cas Number:
- 110-80-5
- Molecular formula:
- C4H10O2
- IUPAC Name:
- 2-ethoxyethan-1-ol
- Details on test material:
- Name of the test substance as stated in the publication: ethylene glycol monoethyl ether (EGEE)
Constituent 1
Results and discussion
Any other information on results incl. tables
Absorption and exposure concentration:
Under resting conditions, an average of 64% of inhaled 2 -ethoxyethanol was retained. R(E) and Cl(atm) remained unchanged as exposure concentration increased. The absorbed dose was apparently proportional to the inhaled concentration and a linear relation between uptake rate and exposure concentration was observed.
Absorption and physical exercise:
Cl(atm) and consequently rate of uptake increased when physical exercise was performed during exposure. This was due not only to an increase in the pulmonary ventilation rate but also to a slight increase in retention. The increase of R(E), however, was not proportional to the level of exercise since no difference was found between 30W and 60W.
Individual respiratory uptake of 2 -ethoxyethanol was governed mainly by pulmonary ventilation, corrected for respiratory frequency, and the concentration of the test substance in the air.
Respiratory elimination and exposure concentration:
The postexposure breath concentration of 2 -ethoxyethanol was measured at regular times for four hours after the exposure period. Exhaled concentrations declined quickly during the first minutes, since the concentration after 7.5 minutes was only 1.5 + 0.6 % of the exhaled concentration during exposure. Thereafter a much slower decrease was observed to levels near the detection limit of the method. Postexposure breath concentrations were higher as exposure concentration and consequently uptake increased.
Postexposure breath concentrations tended to be higher as the physical workload increased but this tendency was not significant.
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