2-ethoxyethanol

Toxicity to terrestrial arthropods

Administrative data

Endpoint:

toxicity to terrestrial arthropods

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable publication

Data source

Reference

Reference Type:

publication

Title:

Pattern of Response of Intact Drosophila to Known Teratogens

Author:

Schuler, R.L. et al.

Year:

1985

Bibliographic source:

J. Am. Coll. Toxicol. 4, 291-303

Materials and methods

Principles of method if other than guideline:

Method: other: teratogenic investigations

GLP compliance:

not specified

Application method:

oral

Test material

Test material information

Constituent 1

Reference substance name:

2-ethoxyethanol

EC Number:

203-804-1

EC Name:

2-ethoxyethanol

Cas Number:

110-80-5

Molecular formula:

C4H10O2

IUPAC Name:

2-ethoxyethan-1-ol

Details on test material:

Name of the test substance as stated in the publication: 2-ethoxyethanol;
purchased from Aldrich Chemical Company;
Purity: "purest availabel grade from the vendor"

Test organisms

Test organisms (species):

Drosophila melanogaster

Study design

Study type:

laboratory study

Results and discussion

Any other information on results incl. tables

A total number of 1262 flies were tested on the test substance 2 -ethoxyethanol.

Abnormalities observed:

- wing notches (9 µL P< 0.001)

- significant reduction of large bristles (macrosetae) (13 µL P < 0.01; 17 µL P < 0.001)

- size reduction of supra-alar bristles

- bent (humeral) bristles (13 µL P < 0.05; 17 µL P < 0.01)

Applicant's summary and conclusion

Conclusions:

The test substance 2-ethoxyethanol induced different developmental abnormalities like wing notches, size reduction of bristles and bending of bristles in Drosophila (adults and larvae).