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Ecotoxicological information

Toxicity to terrestrial arthropods

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Administrative data

Endpoint:
toxicity to terrestrial arthropods
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication

Data source

Reference
Reference Type:
publication
Title:
Pattern of Response of Intact Drosophila to Known Teratogens
Author:
Schuler, R.L. et al.
Year:
1985
Bibliographic source:
J. Am. Coll. Toxicol. 4, 291-303

Materials and methods

Principles of method if other than guideline:
Method: other: teratogenic investigations
GLP compliance:
not specified
Application method:
oral

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name of the test substance as stated in the publication: 2-ethoxyethanol;
purchased from Aldrich Chemical Company;
Purity: "purest availabel grade from the vendor"

Test organisms

Test organisms (species):
Drosophila melanogaster

Study design

Study type:
laboratory study

Results and discussion

Any other information on results incl. tables

A total number of 1262 flies were tested on the test substance 2 -ethoxyethanol.

Abnormalities observed:

- wing notches (9 µL P< 0.001)

- significant reduction of large bristles (macrosetae) (13 µL P < 0.01; 17 µL P < 0.001)

- size reduction of supra-alar bristles

- bent (humeral) bristles (13 µL P < 0.05; 17 µL P < 0.01)

Applicant's summary and conclusion

Conclusions:
The test substance 2-ethoxyethanol induced different developmental abnormalities like wing notches, size reduction of bristles and bending of bristles in Drosophila (adults and larvae).