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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
The Toxicological Basis of Threshold Limit Values: 5. The Experimental Inhalation of Vapor Mixtures by Rats, with Notes upon the Relationship between Single Dose Inhalation and Single Dose Oral Data
Author:
Pozzani U.C., M.S., Weil C.S., M.A., Carpenter C.P., Ph.D.
Year:
1959
Bibliographic source:
Am. Ind. Hyg. Assoc. J. 20, 364-369
Reference Type:
publication
Title:
Use of Moving Averages and Interpolation to Estimate Median-Effective Dose.
Author:
Thompson, W.R.
Year:
1947
Bibliographic source:
Bact. Rev. 11: 115
Reference Type:
publication
Title:
The Assay of Acute Vapor Toxicity, and the Grading and Interpretation of Results on 96 Chemical Compounds.
Author:
Carpenter C.P., Smyth H.F., Jr., and Pozzani, Urbano C.
Year:
1949
Bibliographic source:
J. Ind. Hyg. and Toxicol. 31: 343

Materials and methods

Principles of method if other than guideline:
Acute inhalation toxicity
GLP compliance:
no
Test type:
other: acute inhalation toxicity

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Test substance as stated in publication: "CELLOSOLVE"
Purity: commercial grade

Test animals

Species:
rat
Strain:
other: Carworth Farms-Nelson
Sex:
female

Administration / exposure

Route of administration:
inhalation: vapour
Duration of exposure:
8 h
Concentrations:
4.01 - 13.5 mg/l
No. of animals per sex per dose:
6

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LC50
Effect level:
7.36 mg/L air
Exp. duration:
8 h

Applicant's summary and conclusion

Conclusions:
6 female rats were exposed to different vapour concentrations (4.01 to 13.5 mg/L) of the test substance 2-ethoxyethanol for a single 8-hour period. The LC50 was determined to be 7.36 mg/L, at this concentration 50 % of the exposed animals died.