Registration Dossier

Administrative data

Key value for chemical safety assessment

Effects on developmental toxicity

Description of key information
The lowest NOAEL was determined in the rat with a value of 25 µL/kg/day (23 mg/kg/day with a density of 0.919 g/mL at 25 °C). The doses were administered orally during gestation (key data from Stenger 1971).
For the chemical safety assessment of inhalation exposure a LOAEC derived from a subacute inhalative toxicity study (daily 6 hours during gestation, 10 ppm corresponding to 37.4 mg/m³) in rat (Doe et al. 1984, key study for developmental toxicity, see Endpoint record was used.
Effect on developmental toxicity: via oral route
Dose descriptor:
23 mg/kg bw/day
Effect on developmental toxicity: via inhalation route
Dose descriptor:
37.4 mg/m³

Justification for classification or non-classification