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EC number: 203-804-1 | CAS number: 110-80-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Absorption of Some Glycol Ethers Through Human Skin in Vitro
- Author:
- Dugard, P.H. et al.
- Year:
- 1 984
- Bibliographic source:
- Environ. Health Perspect. 57, 193-197
Materials and methods
- Study type:
- other: skin permeability measurements
- Principles of method if other than guideline:
- Method: other: in vitro permeability measurements in human skin
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-ethoxyethanol
- EC Number:
- 203-804-1
- EC Name:
- 2-ethoxyethanol
- Cas Number:
- 110-80-5
- Molecular formula:
- C4H10O2
- IUPAC Name:
- 2-ethoxyethan-1-ol
- Details on test material:
- Name of the test substance as stated in the publication: 2-ethoxyethanol;
purchased from: ICI Petrochemicals and Plastics Division (Wilton UK);
purity: > 98 %
Constituent 1
Results and discussion
Any other information on results incl. tables
The absorption of the test substance achieved maximum steady rates within the experimental period (8 hr). 2 -ethoxyethanol was readily absorbed.
Skin absorption of 2 -ethoxyethanol:
Compound | Permeability constant, cm/hr x 10^4 | Rate of absorption, mg/cm²/hr | Damage ratio | Approx. lag time, hr |
2 -ethoxyethanol | 8.42 | 0.796 +/-0.460 (n=11) | 2.74 +/-1.46 (n=10) | <1 |
The damage ratio is the ratio of skin permeability to tritiated water after contact with the test compound to that recorded before such
contact. Some slight degree of irreversible damage has been induced by the test substance but this is unlikely to have had a significant
effect on permeability (Control damage ratio values for water contact alone lay between 1.0 and 2.0).
Applicant's summary and conclusion
- Conclusions:
- In an in-vitro experiment the absorption of the test substance 2 -ethoxyethanol across isolated human abdominal epidermis was measured. Some slight degree of irreversible damage has been induced by the test substance but this is unlikely to have had a significant effect on permeability.
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