2-ethoxyethanol

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable publication

Data source

Reference

Reference Type:

publication

Title:

Absorption of Some Glycol Ethers Through Human Skin in Vitro

Author:

Dugard, P.H. et al.

Year:

1984

Bibliographic source:

Environ. Health Perspect. 57, 193-197

Materials and methods

Study type:

other: skin permeability measurements

Principles of method if other than guideline:

Method: other: in vitro permeability measurements in human skin

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-ethoxyethanol

EC Number:

203-804-1

EC Name:

2-ethoxyethanol

Cas Number:

110-80-5

Molecular formula:

C4H10O2

IUPAC Name:

2-ethoxyethan-1-ol

Details on test material:

Name of the test substance as stated in the publication: 2-ethoxyethanol;
purchased from: ICI Petrochemicals and Plastics Division (Wilton UK);
purity: > 98 %

Results and discussion

Any other information on results incl. tables

The absorption of the test substance achieved maximum steady rates within the experimental period (8 hr). 2 -ethoxyethanol was readily absorbed.

Skin absorption of 2 -ethoxyethanol:

Compound	Permeability constant, cm/hr x 10^4	Rate of absorption, mg/cm²/hr	Damage ratio	Approx. lag time, hr
2 -ethoxyethanol	8.42	0.796 +/-0.460 (n=11)	2.74 +/-1.46 (n=10)	<1

The damage ratio is the ratio of skin permeability to tritiated water after contact with the test compound to that recorded before such

contact. Some slight degree of irreversible damage has been induced by the test substance but this is unlikely to have had a significant

effect on permeability (Control damage ratio values for water contact alone lay between 1.0 and 2.0).

Applicant's summary and conclusion

Conclusions:

In an in-vitro experiment the absorption of the test substance 2 -ethoxyethanol across isolated human abdominal epidermis was measured. Some slight degree of irreversible damage has been induced by the test substance but this is unlikely to have had a significant effect on permeability.