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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication and testing conducted according to a standardized procedure

Data source

Reference
Reference Type:
publication
Title:
Experimental study of cutaneous tolerance to glycol ethers
Author:
Zissu, D.
Year:
1995
Bibliographic source:
Contact Dermatitis 32, 74-77

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Directive annex: 92/69/EEC: July 1992
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name of the test substance as stated in the publication: 2-ethoxyethanol;
purchased from: Merck;
purity: > 99 %

Test animals

Species:
rabbit
Strain:
other: New Zealand albino

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
other: animal served as its own control
Duration of treatment / exposure:
4 h
Observation period:
72 h
Number of animals:
3

Results and discussion

Any other information on results incl. tables

Macroscopic investigation of cutaneous irritation according to the method of the official Journal of the European Communities showed that the test substance 2 -ethoxyethanol was non-irritant.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information
Conclusions:
The skin irritating potential of the test substance 2-ethoxyethanol was evaluated according to the Directive annex: 92/69/EEC: July 1992 on the skin of New Zealand albino rabbits. The test substance was applied undiluted occlusively for 4 hours. The result showed that the test substance was not irritating.