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Toxicological information

Toxicity to reproduction: other studies

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Administrative data

Endpoint:
toxicity to reproduction: other studies
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: NIOSH report
Title:
Reproductive Effects of Glycol Ethers in Females -- A Quantitative Analysis
Author:
Ballew, M. and Hattis, D.
Year:
1989
Bibliographic source:
NTIS Report No. PB 129222

Materials and methods

GLP compliance:
not specified
Type of method:
other: risk estimation

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethoxyethanol
EC Number:
203-804-1
EC Name:
2-ethoxyethanol
Cas Number:
110-80-5
Molecular formula:
C4H10O2
IUPAC Name:
2-ethoxyethanol
Details on test material:
Name of the test substance as stated in the publication: Ethylene glycol monoethyl ether

Results and discussion

Any other information on results incl. tables

Reproductive effect     Projected reproductive risk frequency for effect         Doses (ppm 2 -ethoxyethanol) projected to be associated with the risk*
 Lower limit  Best estimate
Miscarriages   10^(-6)  0.00056  0.53
    10^(-4) 0.0061   1.8
 Minor skeletal defects   10^(-6)   4.4 x 10^(-6)  0.022
    10^(-4)  4.8 x 10^(-5)   0.073
 External malformations   10^(-6)   0.0011  1.1
     10^(-4)  0.012  3.5
 Digit or limb malformations    10^(-6)  -  -
     10^(-4)  -  -
 Total malformations    10^(-6)  -  -
     10^(-4)  -  -
 Infant mortality (projected from fetal weight changes)    10^(-6)  -  0.069
   10^(-4)  -  6.8

* Values in the lower limit column represent the doses associated with the indicated level of effect under a more pessimistic assumption about the degree of interindividual variability in susceptibility of the human population (log probit slop 1). Values in the best estimate column represent calculations using the investigators' "best-estimate" assumption of the degree of interindividual variability in susceptibility for the quantal effects (log probit slop 2).

Applicant's summary and conclusion