Registration Dossier

Administrative data

Endpoint:
biological effects monitoring
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable procedure and publication

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Cytotoxicity of 109 Chemicals to Goldfish GFS Cells and Relationships with 1-Octanol/Water Partition Coefficients
Author:
Saito, H. et al.
Year:
1993
Bibliographic source:
Chemosphere 26(5), 1015-1028
Reference Type:
publication
Title:
Quantitative Structure-Activity Relationships in Fish Toxicity Studies
Author:
Koenemann, H.
Year:
1981
Bibliographic source:
Toxicology, 19, 209-221

Materials and methods

Principles of method if other than guideline:
Neutral red (NR) assay
GLP compliance:
not specified
Type of study / information:
Midpoint cytotoxicity of 2-ethoxyethanol to goldfish scale GFS cells compared with the fish acute toxicities and partition coefficient (log Pow).

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name of the test substance as stated in the publication: 2-ethoxyethanol
Purchased from: Tokyo Kasei Kogyo Co., Tokyo, Japan;
Purity: " reagent-grade"

Results and discussion

Any other information on results incl. tables

Data of log Pow, NR50 for GFS cells and LC50 for guppy: (log Pow and LC50 values from Koenemann, H. (1981))

  Log Pow   Log 1/NR50 (mmol/L)  Log 1/LC50 (mmol/L), guppy
 2 -ethoxyethanol  -0.21  -2.54  -2.26

Applicant's summary and conclusion

Conclusions:
The 24-hr NR50 values (in vitro) for the cytotoxicity of the test compound 2-ethoxyethanol to GFS cells, together with their log Pow and LC50 data (in vivo) for guppy gave good correlations.