Registration Dossier
Registration Dossier
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EC number: 203-804-1 | CAS number: 110-80-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable publication but no info about substance purity
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Study of intra- and interlaboratory variability in the results of rabbit eye and skin irritation tests.
- Author:
- Weil CS, Scala RA
- Year:
- 1 971
- Bibliographic source:
- Toxicol. Appl. Pharmacol. 19, 276-360
- Reference Type:
- publication
- Title:
- Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes.
- Author:
- Draize, J.H., Woodard, G., and Calvery, H.O.
- Year:
- 1 944
- Bibliographic source:
- J. Pharmacol. Exp. Ther. 82, 377-389
Materials and methods
- Principles of method if other than guideline:
- Method: Draize Test
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-ethoxyethanol
- EC Number:
- 203-804-1
- EC Name:
- 2-ethoxyethanol
- Cas Number:
- 110-80-5
- Molecular formula:
- C4H10O2
- IUPAC Name:
- 2-ethoxyethan-1-ol
- Details on test material:
- substance identity as stated in publication: Ethylene glycol monoethyl ether
purity: no data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino rabbits
- Details on test animals or tissues and environmental conditions:
- Animal weight: at least 2.0 kg
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- undiluted
Amount applied: 0.1 ml - Duration of treatment / exposure:
- 1 h
- Observation period (in vivo):
- 1, 24 and 72 hours and 7 days after application
- Number of animals or in vitro replicates:
- 6 animals per laboratory (in total 24 laboratories -> 144 animals)
- Details on study design:
- Comment: no data
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 7.8
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 7 d
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 20.8
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 7 d
Any other information on results incl. tables
Summary of the obtained results:
Individual scale range of all experiments | Median of 6 animals/laboratory | Median of 24 laboratory medians | |
after 24 h | 0 -65 | 1 -60 | 20.8 |
after 72 h | 0 -64 | 0 -35 | 7.8 |
after 7 days | 0 -54 | 0 -20.5 | 0 |
The published results are summarizied results obtained from 24 different laboratories all testing the eye-irritation of 2 -Ethoxyethanol:
19 of 24 laboratories rated the test substance as "irritant", 3 of 24 as "nonirritant" and 2 of 24 as "questionable" (nonirritant: 0 or 1 rabbit eye with positive score; questionable: 2 or 3 rabbit eyes with positive score; irritant: 4, 5, or 6 rabbit eyes with positive score).
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information
- Conclusions:
- 24 different laboratories evaluated the eye irritation potential of the test substance 2-ethoxyethanol. The test animals (6 per laboratory, 144 in total) were albino rabbits and the scoring occurred according to Draize et al. (1944). By summarizing all results after 24 hours a median score of all laboratories of 20.8/110 was determined. However, 19/24 laboratories evaluated the test substance as irritant, 2/24 as questionable, and 3/24 as nonirritant. According to these results the author of this IUCLID dossier interpreted the test substance to be slightly irritating. Therefore the results of this key study are conclusive but not sufficient for classification as eye irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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