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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Immunotoxicity

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Administrative data

Endpoint:
immunotoxicity: acute oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication

Data source

Reference
Reference Type:
publication
Title:
Comparative immunosuppression of various glycol ethers orally administered to Fischer 344 rats
Author:
Smialowrcz RJ, Williams WC, Riddle MM, Andrews DL, Luebke RW, Copeland CB
Year:
1992
Bibliographic source:
Fundament Appl Toxicol 18, 621-627

Materials and methods

Principles of method if other than guideline:
Method: other: immune response to TNP-LPS by PFC assay
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethoxyethanol
EC Number:
203-804-1
EC Name:
2-ethoxyethanol
Cas Number:
110-80-5
Molecular formula:
C4H10O2
IUPAC Name:
2-ethoxyethan-1-ol
Details on test material:
Name of the test substance as stated in the publication: 2-ethoxyethanol

Test animals

Species:
rat
Strain:
other: Fischer 344 (CDF[F344]/CrlBr
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: distilled water
No. of animals per sex per dose:
6
Control animals:
yes, concurrent vehicle

Results and discussion

Any other information on results incl. tables

Exposure of rats to the test substance failed to alter the antibody response to TNP-LPS:

 Treatment (mg/kg/day)  PFC / 10^6 cells  PFC / spleen (x 10^(-4))  Cells /spleen (x 10^(-6))  Titer (log2)
 0  502 +/-61  30.4 +/- 4.0  607 +/-36  4.7 +/-0.2
 50  408 +/-51  254 +/-3.9  614 +/-35  5.5 +/-0.4
 100  678 +/-76  38.9 +/-6.2  562 +/-27  5.2 +/-0.5
 200  427 +/-39  22.8 +/-1.6  540 +/-26  3.3 +/-0.3
 400  505 +/-86  26.0 +/-4.7  515 +/-15  3.5 +/-0.3

Applicant's summary and conclusion

Conclusions:
The exposure of male Fischer 344 rats to the test substance 2-ethoxyethanol did not affect the antibody response to TNP-LPS.