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Toxicological information

Immunotoxicity

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Administrative data

Endpoint:
immunotoxicity: acute oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication

Data source

Reference
Reference Type:
publication
Title:
Comparative immunosuppression of various glycol ethers orally administered to Fischer 344 rats
Author:
Smialowrcz RJ, Williams WC, Riddle MM, Andrews DL, Luebke RW, Copeland CB
Year:
1992
Bibliographic source:
Fundament Appl Toxicol 18, 621-627

Materials and methods

Principles of method if other than guideline:
Method: other: immune response to TNP-LPS by PFC assay
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name of the test substance as stated in the publication: 2-ethoxyethanol

Test animals

Species:
rat
Strain:
other: Fischer 344 (CDF[F344]/CrlBr
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: distilled water
No. of animals per sex per dose:
6
Control animals:
yes, concurrent vehicle

Results and discussion

Any other information on results incl. tables

Exposure of rats to the test substance failed to alter the antibody response to TNP-LPS:

 Treatment (mg/kg/day)  PFC / 10^6 cells  PFC / spleen (x 10^(-4))  Cells /spleen (x 10^(-6))  Titer (log2)
 0  502 +/-61  30.4 +/- 4.0  607 +/-36  4.7 +/-0.2
 50  408 +/-51  254 +/-3.9  614 +/-35  5.5 +/-0.4
 100  678 +/-76  38.9 +/-6.2  562 +/-27  5.2 +/-0.5
 200  427 +/-39  22.8 +/-1.6  540 +/-26  3.3 +/-0.3
 400  505 +/-86  26.0 +/-4.7  515 +/-15  3.5 +/-0.3

Applicant's summary and conclusion

Conclusions:
The exposure of male Fischer 344 rats to the test substance 2-ethoxyethanol did not affect the antibody response to TNP-LPS.