Previous Testing Proposals
Previous Testing Proposals
Previous Testing Proposals
This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.
To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.
N,N'-bis(2,2,6,6-tetramethyl-4-piperidyl)isophthalamide | 419-710-0 | - |
Sub-chronic toxicity (90-day): oral Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) |
12/12/2014 12/12/2014 12/12/2014 |
26/01/2015 26/01/2015 26/01/2015 |
Details | |
N,N'-(methylenedi-p-phenylene)bis[hexahydro-2-oxo-1H-azepine-1-carboxamide] | 258-981-8 | 54112-23-1 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
12/12/2014 12/12/2014 |
26/01/2015 26/01/2015 |
Details | |
N-(dimethylvinylsilyl)-1,1-dimethyl-1-vinylsilylamine | 231-701-1 | 7691-02-3 |
Sub-chronic toxicity (90 day): inhalation
“|| Note: Testing proposed with hexamethyldisilazane (CAS 999-97-3)” Reproductive toxicity (pre-natal developmental toxicity)
“|| Note: Testing proposed with hexamethyldisilazane (CAS 999-97-3)” |
12/12/2014 12/12/2014 |
26/01/2015 26/01/2015 |
Details | |
Reaction mass of ethoxylated (≥ 3 moles) bisphenol A dimethacrylate and (1-methylethylidene)bis(4,1-phenyleneoxy-2,1-ethanediyl) bismethacrylate | 939-702-5 | - |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Ethoxylated bisphenol A diacrylate Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Ethoxylated bisphenol A diacrylate |
12/12/2014 12/12/2014 |
26/01/2015 26/01/2015 |
Details | |
1,1,1,3,5,5,5-heptamethyl-3-[(trimethylsilyl)oxy]trisiloxane | 241-867-7 | 17928-28-8 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with decamethyltetrasiloxane (EC no. 205-491-7, CAS no. 141-62-8) | 12/12/2014 | 26/01/2015 | Details | |
1,1,4,4-tetramethylbutane-1,4-diyl bis(2-ethylperoxyhexanoate) | 235-935-5 | 13052-09-0 | Long-term toxicity to fish || Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates | 12/12/2014 | 26/01/2015 | Details | |
3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate, oligomers, reaction products with 2-butanone oxime | 500-287-7 | 103170-26-9 | Sub-chronic toxicity (90 day): inhalation | 12/12/2014 | 26/01/2015 | Details | |
chlorodimethylvinylsilane | 217-007-1 | 1719-58-0 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Trimethylsilanol (CAS 1066-40-6) | 12/12/2014 | 26/01/2015 | Details | |
Hexamethylene diisocyanate, oligomerisation product, blocked with 3,5-dimethyl-1H-pyrazole | 605-318-9 | 163206-31-3 | Sub-chronic toxicity (90 day): inhalation | 12/12/2014 | 26/01/2015 | Details | |
Reaction mass of Amines, coco alkyl and β-Alanine, N-(2-carboxyethyl)-, N-coco alkyl derivs. and β-Alanine, N-coco alkyl derivs. | 915-790-0 | - | Sub-chronic toxicity (90-day): oral | 12/12/2014 | 26/01/2015 | Details | |
Reaction products of hexane-1,6-diol with 2-(chloromethyl)oxirane | 618-939-5 | 933999-84-9 |
Sub-chronic toxicity (90 day): dermal Reproductive toxicity (two-generation reproductive toxicity) Reproductive toxicity (pre-natal developmental toxicity) |
18/11/2014 18/11/2014 18/11/2014 |
02/01/2015 02/01/2015 02/01/2015 |
Details | |
Reaction mass of 2,2'-[(4-methylphenyl)imino]bisethanol and Ethanol 2-[[2-(2-hydroxyethoxy)ethyl](4-methylphenyl)amino]- | 911-490-9 | - |
Reproductive toxicity (pre-natal developmental toxicity) Genetic toxicity in vivo |
18/11/2014 18/11/2014 |
02/01/2015 02/01/2015 |
Details | |
3,5-diamino-4-[[4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]azo]-2-[[2-sulfo-4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]azo]benzoic acid sodium salt | 480-890-9 | 906532-68-1 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 18/11/2014 | 02/01/2015 | Details | |
2,4,8,10-tetra(tert-butyl)-6-hydroxy-12H-dibenzo[d,g][1,3,2]dioxaphosphocin 6-oxide, sodium salt | 286-344-4 | 85209-91-2 |
Long-term toxicity to fish Reproductive toxicity (two-generation reproductive toxicity) Reproductive toxicity (pre-natal developmental toxicity) |
16/10/2014 16/10/2014 16/10/2014 |
01/12/2014 01/12/2014 01/12/2014 |
Details | |
3-(triethoxysilyl)propanethiol | 238-883-1 | 14814-09-6 |
Reproductive toxicity (pre-natal developmental toxicity) Genetic toxicity in vivo Sub-chronic toxicity (90-day): oral |
16/10/2014 16/10/2014 16/10/2014 |
01/12/2014 01/12/2014 01/12/2014 |
Details | |
triethoxy(3-thiocyanatopropyl)silane | 252-161-3 | 34708-08-2 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/10/2014 16/10/2014 16/10/2014 |
01/12/2014 01/12/2014 01/12/2014 |
Details | |
2-Oxepanone, polymer with 1,6-hexanediol | 609-271-5 | 36609-29-7 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 2-Oxepanone, polymer with 1,4-butanediol Sub-chronic toxicity (90-day): oral || Note: testing proposed with 2-Oxepanone, polymer with 1,4-butanediol |
16/10/2014 16/10/2014 |
01/12/2014 01/12/2014 |
Details | |
3,3-bis[(dimethylvinylsilyl)oxy]-1,1,5,5-tetramethyl-1,5-divinyltrisiloxane | 262-061-1 | 60111-54-8 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/10/2014 16/10/2014 |
01/12/2014 01/12/2014 |
Details | |
Fatty acids, C18-unsatd., dimers, polymers with oleic acid and triethylenetetramine | 614-339-2 | 68154-62-1 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine (EC 500-191-5, CAS 68082-29-1) Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with fatty acids, C18-unsatd., dimers, oligomeric reaction products with tall-oil fatty acids and triethylenetetramine (EC 500-191-5, CAS 68082-29-1) |
16/10/2014 16/10/2014 |
01/12/2014 01/12/2014 |
Details | |
hexadecyltrimethoxysilane | 240-464-3 | 16415-12-6 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/10/2014 16/10/2014 |
01/12/2014 01/12/2014 |
Details | |
(chloromethyl)triethoxysilane | 239-311-3 | 15267-95-5 | Genetic toxicity in vivo | 16/10/2014 | 01/12/2014 | Details | |
2-Propyn-1-ol, compd. with methyloxirane | 609-530-2 | 38172-91-7 | Sub-chronic toxicity (90-day): oral | 16/10/2014 | 01/12/2014 | Details | |
4,4'-(9H-fluoren-9-ylidene)bis(2-chloroaniline) | 407-560-9 | 107934-68-9 | Bioaccumulation aquatic / sediment || Note: Testing proposal is based on concern identified by the registrant. | 16/10/2014 | 01/12/2014 | Details | |
decamethyltetrasiloxane | 205-491-7 | 141-62-8 | Reproductive toxicity (pre-natal developmental toxicity) | 16/10/2014 | 01/12/2014 | Details | |
dichloro(3-chloropropyl)methylsilane | 232-136-3 | 7787-93-1 | Reproductive toxicity (pre-natal developmental toxicity)|| Note: testing proposed with (3-chloropropyl)triethoxysilane (EC 225-805-6, CAS 5089-70-3) | 16/10/2014 | 01/12/2014 | Details | |
dimethoxydimethylsilane | 214-189-4 | 1112-39-6 | Sub-chronic toxicity (90 day): inhalation | 16/10/2014 | 01/12/2014 | Details | |
dimethoxymethylsilane | 240-914-9 | 16881-77-9 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with trimethoxy(methyl)silane. | 16/10/2014 | 01/12/2014 | Details | |
Hexafluoropropene, oxidized, oligomers, reduced, fluorinated | 500-537-5 | 161075-00-9 | Bioaccumulation aquatic / sediment | 16/10/2014 | 01/12/2014 | Details | |
hexahydrophthalic acid diglycidylester | 696-026-0 | 1395383-69-3 | Sub-chronic toxicity (90-day): oral | 16/10/2014 | 01/12/2014 | Details | |
Octadecylamine, reaction products with 4,4'-methylenediphenyl diisocyanate | 928-226-3 | - | Sub-chronic toxicity (90-day): oral | 16/10/2014 | 01/12/2014 | Details | |
reaction mass of: triphenylthiophosphate and tertiary butylated phenyl derivatives | 421-820-9 | 192268-65-8 | Reproductive toxicity (pre-natal developmental toxicity) | 16/10/2014 | 01/12/2014 | Details | |
triethoxy(methyl)silane | 217-983-9 | 2031-67-6 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with trimethoxy(methyl)silane. | 16/10/2014 | 01/12/2014 | Details | |
undec-10-enoic acid | 203-965-8 | 112-38-9 | Long-term toxicity to fish | 16/10/2014 | 01/12/2014 | Details | |
Esterification products of 4,4'-isopropylidenediphenol, ethoxylated and prop-2-enoic acid. | 613-584-2 | 64401-02-1 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
18/09/2014 18/11/2014 |
03/11/2014 02/01/2015 |
Details | |
1,3-diphenylpropane-1,3-dione | 204-398-9 | 120-46-7 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) Genetic toxicity in vivo |
18/09/2014 18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 03/11/2014 |
Details | |
1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C12-18(even numbered) acyl) derivs., hydroxides, inner salts | 939-457-4 | - |
Long-term toxicity to fish Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
18/09/2014 18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 03/11/2014 |
Details | |
1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C8-18(even numbered) acyl) derivs., hydroxides, inner salts | 939-455-3 | - |
Long-term toxicity to fish Sub-chronic toxicity (90 day): oral Reproductive toxicity (pre-natal developmental toxicity) |
18/09/2014 18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 03/11/2014 |
Details | |
1,1'-(isopropylidene)bis[3,5-dibromo-4-(2,3-dibromopropoxy)benzene] | 244-617-5 | 21850-44-2 |
Reproductive toxicity (two-generation reproductive toxicity) Reproductive toxicity (pre-natal developmental toxicity) |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
1,4-diisopropylbenzene | 202-826-9 | 100-18-5 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with CAS no. 99-62-7 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with CAS no. 99-62-7 |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
2-amino-2-ethylpropanediol | 204-101-2 | 115-70-8 |
Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with 2-amino-1,3-propanediol Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with 2-amino-1,3-propanediol |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
2-Butyne-1,4-diol, polymer with 2-(chloromethyl)oxirane, brominated, dehydrochlorinated, methoxylated | 614-503-3 | 68441-62-3 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposed on rabbit. Reproductive toxicity (two-generation reproductive toxicity) |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with 2-methylimidazole | 500-181-0 | 68002-42-6 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
4-methylthiosemicarbazide | 229-563-2 | 6610-29-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
bismuth citrate | 212-390-1 | 813-93-4 |
Sub-chronic toxicity (90-day): oral || Note: testing proposed with bismuth hydroxide nitrate oxide (EC 215-136-8, CAS 1304-85-4) Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with bismuth hydroxide nitrate oxide (EC 215-136-8, CAS 1304-85-4) |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
fatty acids, C16 and C18 unsatd., polymers with bisphenol A, Bu glycidyl ether, epichlorohydrin and triethylenetetramine | 600-687-2 | 105839-18-7 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
hex-3-yne-2,5-diol | 221-209-5 | 3031-66-1 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
N-[3-(dimethylamino)propyl] C 12-C18 alkylamide | 932-121-8 | 1147459-12-8 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
N-[3-(trimethoxysilyl)propyl]butylamine // Note: testing proposed with N-(3-(trimethoxysilyl)propyl)ethylenediamine (EC No. 217-164-6) | 250-437-8 | 31024-56-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
sodium O,O-diethyl dithiophosphate || Note: testing proposed with sodium O,O-diisobutyl dithiophosphate (EC 258-508-5) | 222-079-2 | 3338-24-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
2,2'-ethylenedioxydiethyl bis(2-ethylhexanoate) | 202-319-2 | 94-28-0 | Reproductive toxicity (two-generation reproductive toxicity) | 18/09/2014 | 03/11/2014 | Details | |