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Previous Testing Proposals

Previous Testing Proposals

This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.

Further instructions

To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.

 
Reaction mass of Octadecanamide, 12-hydroxy-N-[2-[(1-oxodecyl)amino]ethyl]- and N,N'-ethane-1,2-diylbis(12-hydroxyoctadecan-1-amide) and Decanamide, N,N'-1,2-ethanediylbis- 907-495-0 -
Reproductive toxicity (pre-natal developmental toxicity): in rat and rabbit
Sub-chronic toxicity (90 day): inhalation
Reproductive toxicity (extended one-generation reproductive toxicity study)
27/05/2019
27/05/2019
27/05/2019
11/07/2019
11/07/2019
11/07/2019
Benzene, 1,1'-oxybis-, tetrapropylene derivatives, sulfonated, sodium salts 601-601-6 119345-04-9
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity) with the Rabbit
27/05/2019
27/05/2019
11/07/2019
11/07/2019
Lithium bis(oxalato)borate 456-990-3 -
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
27/05/2019
27/05/2019
11/07/2019
11/07/2019
Methylphosphonic acid 213-607-2 993-13-5
Sub-chronic toxicity (90-day): oral || Note: testing proposed with Methylphosphonic acid, compound with amidinourea (1:1) (EC 282-758-4)
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Methylphosphonic acid, compound with amidinourea (1:1) (EC 282-758-4)
27/05/2019
27/05/2019
11/07/2019
11/07/2019
tri{[(2s)-1-ethoxy-1-oxopropan-2-yl]oxy}(vinyl)silane 701-301-6 -
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
27/05/2019
27/05/2019
11/07/2019
11/07/2019
[1,3(or 1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide 246-678-3 25155-25-3 Reproductive toxicity (extended one-generation reproductive toxicity study) 27/05/2019 11/07/2019
Alcohols, C11-14-iso-, C13-rich 271-235-6 68526-86-3 Reproductive toxicity (pre-natal developmental toxicity) 27/05/2019 11/07/2019
Butyl (dialkyloxy(dibutoxyphosphoryloxy))titanium(trialkyloxy)titanium phosphate 401-100-0 - Sub-chronic toxicity (90-day): oral 27/05/2019 11/07/2019
Furan-2,5-dicarboxylic acid 221-800-8 3238-40-2 Reproductive toxicity (pre-natal developmental toxicity) 27/05/2019 11/07/2019
Hexanal 200-624-5 66-25-1 Genetic toxicity in vivo “|| Note: Testing proposal is based on concern identified by the registrant.” 27/05/2019 11/07/2019
Reaction mass of 2,2'-[(4-methylphenyl)imino]bisethanol and Ethanol 2-[[2-(2-hydroxyethoxy)ethyl](4-methylphenyl)amino]- 911-490-9 - Sub-chronic toxicity (90-day): oral 27/05/2019 11/07/2019
Reaction mass of 2-(2-(2-butoxyethoxy)ethoxy)ethanol and 3,6,9,12-tetraoxahexadecan-1-ol 907-996-4 - Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with 2-(2-(2-butoxyethoxy)ethoxy)ethanol (EC 205-592-6) 27/05/2019 11/07/2019
Reaction Mass of Benzyl (1R,1S) 2,2,4-trimethyl-1-[(2-methylpropanoyl)oxy]pentan-3-yl benzene-1,2-dicarboxylate and Benzyl (3R,3S) 2,2,4-trimethyl-3-[(2-methylpropanoyl)oxy]pentyl benzene-1,2-dicarboxylate 701-008-3 - Reproductive toxicity (extended one-generation reproductive toxicity study) 27/05/2019 11/07/2019
Sodium hydroxymethanesulphinate 205-739-4 149-44-0 Reproductive toxicity (pre-natal developmental toxicity) 27/05/2019 11/07/2019
Isobutyric acid, monoester with 2,2,4-trimethylpentane-1,3-diol 246-771-9 25265-77-4
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
26/04/2019
26/04/2019
26/04/2019
10/06/2019
10/06/2019
10/06/2019
Zinc, O,O-mixed (iso-Bu), (iso-Pr), (pentyl) phosphorodithioate 820-225-5 101747-77-7
Sub-chronic toxicity (90-day): oral “|| Note: testing proposed with [Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts] (EC 270-608-0)
Reproductive toxicity (extended one-generation reproductive toxicity study) “|| Note: testing proposed with [Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts] (EC 270-608-0)
Reproductive toxicity (pre-natal developmental toxicity) “|| Note: testing proposed with [Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts] (EC 270-608-0)
26/04/2019
26/04/2019
26/04/2019
10/06/2019
10/06/2019
10/06/2019
3-(trimethoxysilyl)propylamine 237-511-5 13822-56-5
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
26/04/2019
26/04/2019
10/06/2019
10/06/2019
Biphenyl-4,4'-diol 202-200-5 92-88-6
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
26/04/2019
26/04/2019
10/06/2019
10/06/2019
Ethylenediamine, propoxylated 500-035-6 25214-63-5
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
26/04/2019
26/04/2019
10/06/2019
10/06/2019
2-Propyn-1-ol, reaction product with 1-2.5 moles of oxirane 941-793-1 - Reproductive toxicity (pre-natal developmental toxicity) 26/04/2019 10/06/2019
3-trimethoxysilylpropyl methacrylate 219-785-8 2530-85-0 Reproductive toxicity (pre-natal developmental toxicity) 26/04/2019 10/06/2019
Propylidynetrimethyl trimethacrylate 221-950-4 3290-92-4 Reproductive toxicity (extended one-generation reproductive toxicity study) 26/04/2019 10/06/2019
Strontium neodecanoate 812-724-1 106705-37-7 Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with [Strontium oxide] (EC 215-219-9) 26/04/2019 10/06/2019
Perfluamine 206-420-2 338-83-0
Genetic toxicity in vivo (Mammalian Erythrocyte Micronucleus Test)
Genetic toxicity in vivo (In vivo Mammalian Alkaline Comet Assay)
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
29/03/2019
29/03/2019
29/03/2019
29/03/2019
13/05/2019
13/05/2019
13/05/2019
13/05/2019
Reaction mass of 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid and 2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid 940-877-5 -
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
29/03/2019
29/03/2019
13/05/2019
13/05/2019
Distillates (petroleum), hydrodesulfurized middle 265-183-3 64742-80-9
Sub-chronic toxicity (90 day): dermal
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
28/02/2019
28/02/2019
28/02/2019
15/04/2019
15/04/2019
15/04/2019
Distillates (petroleum), hydrotreated middle 265-148-2 64742-46-7
Sub-chronic toxicity (90 day): dermal
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
28/02/2019
28/02/2019
28/02/2019
15/04/2019
15/04/2019
15/04/2019
Extracts (petroleum), deasphalted vacuum residue solvent 295-332-8 91995-70-9
Sub-chronic toxicity (90 day): dermal
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
28/02/2019
28/02/2019
28/02/2019
15/04/2019
15/04/2019
15/04/2019
Extracts (petroleum), residual oil solvent 265-110-5 64742-10-5
Sub-chronic toxicity (90 day): dermal
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
28/02/2019
28/02/2019
28/02/2019
15/04/2019
15/04/2019
15/04/2019
Gas oils (petroleum), hydrodesulfurized 265-182-8 64742-79-6
Sub-chronic toxicity (90 day): dermal
Reproductive toxicity (extended one-generation reproductive toxicity study)
Reproductive toxicity (pre-natal developmental toxicity)
28/02/2019
28/02/2019
28/02/2019
15/04/2019
15/04/2019
15/04/2019
3a,4,7,7a-tetrahydro-4,7-methanoindene 201-052-9 77-73-6 Reproductive toxicity (pre-natal developmental toxicity) 28/02/2019 15/04/2019
Hydrocarbons, C16-C18, isoalkanes,<2% aromatics 948-766-3 - Reproductive toxicity (extended one-generation reproductive toxicity study) 28/02/2019 15/04/2019
Nickel 231-111-4 7440-02-0 Reproductive toxicity (extended one-generation reproductive toxicity study) 28/02/2019 15/04/2019
Reaction products of acrylic acid with 2,2'-[oxybis(methylene)]bis[2-ethylpropane-1,3-diol] 830-217-3 1393932-71-2
Sub-chronic toxicity (90-day): oral || Note: Link to registration dossier not given as the dossier not yet disseminated
Reproductive toxicity (pre-natal developmental toxicity) || Note: Link to registration dossier not given as the dossier not yet disseminated
24/01/2019
24/01/2019
11/03/2019
11/03/2019
1,3,2-dioxathiolane 2,2-dioxide 600-809-4 1072-53-3 Genetic toxicity in vivo || Note: Link to registration dossier not given as the dossier not yet disseminated || Note: Testing proposal is based on concern identified by the registrant. 24/01/2019 11/03/2019
N-(3-aminopropyl)-N'-C16-18 (evennumbered), C18 unsaturated alkyl -propane-1,3-diamine 628-863-4 1219458-14-6 Reproductive toxicity (pre-natal developmental toxicity) 24/01/2019 11/03/2019
Reaction mass of N,N,N',N'-tetrabutylmethylenediamine and dibutylamine 948-040-6 - Genetic toxicity in vivo || Note: Link to registration dossier not given as the dossier not yet disseminated. || Note: Testing proposal is based on concern identified by the registrant. 24/01/2019 11/03/2019
benzyl butyl cis-cyclohexane-1,2-dicarboxylate 701-279-8 1931129-39-3
Long-term toxicity to fish || Note: Link to the registration dossier not given as the dossier not yet disseminated. || Note: this substance was previously registered, identified and disseminated with EC No. 810-685-5
Sub-chronic toxicity (90-day): oral || Note: Link to registration dossier not given as the dossier not yet disseminated. || Note: this substance was previously registered, identified and disseminated with EC No. 810-685-5
Reproductive toxicity (pre-natal developmental toxicity) || Note: Link to registration dossier not given as the dossier not yet disseminated. || Note: this substance was previously registered, identified and disseminated with EC No. 810-685-5
10/12/2018
10/12/2018
10/12/2018
24/01/2019
24/01/2019
24/01/2019
hexamolybdenum(3+) tris((dioctylcarbamothioyl)sulfanide) tris((ditridecylcarbamothioyl)sulfanide) hexahydrate hexasulfanediide 441-570-4 -
Bioaccumulation aquatic / sediment || Note: Link to registration dossier not given as the dossier not yet disseminated.
Sub-chronic toxicity (90-day): oral || Note: Link to registration dossier not given as the dossier not yet disseminated.
Reproductive toxicity (pre-natal developmental toxicity) || Note: Link to registration dossier not given as the dossier not yet disseminated.
10/12/2018
10/12/2018
10/12/2018
24/01/2019
24/01/2019
24/01/2019
1,4-Cyclohexanedicarboxylic acid, 1,4-diisononyl ester 701-012-5 -
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
10/12/2018
10/12/2018
24/01/2019
24/01/2019
4-oxovaleric acid 204-649-2 123-76-2
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
10/12/2018
10/12/2018
24/01/2019
24/01/2019
Propionaldehyde, reaction product with formaldehyde 701-281-9 - Genetic toxicity in vivo || Note: the EC/list number of the substance has been changed. 10/12/2018 24/01/2019
Fatty acids, C12-14, α-sulfo, disodium salts 942-523-5 -
Sub-chronic toxicity (90-day): oral
Reproductive toxicity (pre-natal developmental toxicity)
02/11/2018
02/11/2018
17/12/2018
17/12/2018
1-Dodecene, dimers 814-509-8 62132-67-6 Reproductive toxicity (pre-natal developmental toxicity) 02/11/2018 17/12/2018
2,2,4,4,6,8,8-heptamethylnonane 224-506-8 4390-04-9 Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with two substances in a grouping approach: Icosane (EC 204-015-1) and Hydrocarbons, C14-C19, iso-alkanes, cyclics; aromatics <2% (920-114-2) 02/11/2018 17/12/2018
Alkane-alpha,omega-diyl bis{[(trimethoxysilyl)propyl]carbamate}_M2 700-904-1 1350725-68-6 Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Methyl [3-(trimethoxysilyl) propyl]carbamate CAS 23432-62-4 02/11/2018 17/12/2018
Alkenes, C13-14, hydroformylation products, distn. residues 292-429-7 90622-29-0 Reproductive toxicity (extended one-generation reproductive toxicity study) “|| Note: testing proposed with Alkenes, C11-12, hydroformylation products, distn. residues (EC 292-427-6) 02/11/2018 17/12/2018
Alkenes, C7-9, hydroformylation products, distn. residues, heavy cracked fraction 308-482-7 98072-31-2 Reproductive toxicity (extended one-generation reproductive toxicity study) 02/11/2018 17/12/2018
Diethyl ether 200-467-2 60-29-7 Reproductive toxicity (extended one-generation reproductive toxicity study) 02/11/2018 17/12/2018
Hydrocarbons, C14-C16, n-alkanes, <2% aromatics 921-535-4 - Reproductive toxicity (extended one-generation reproductive toxicity study) 02/11/2018 17/12/2018



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