Previous Testing Proposals
Previous Testing Proposals
Previous Testing Proposals
This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.
To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.
Reaction mass of (2S-cis)-tetrahydro-4-methyl-2-(2-methyl-1-propenyl)-2H-pyran and Tetrahydro-4-methyl-2-(2-methylpropen-1-yl)pyran (2R,4R) and Tetrahydro-4-methyl-2-(2-methylpropen-1-yl)pyran (2S,4S) and (2R-cis)-tetrahydro-4-methyl-2-(2-methyl-1-propenyl)-2H-pyran | 939-429-1 | 16409-43-1 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
30/11/2015 30/11/2015 |
14/01/2016 14/01/2016 |
Details | |
(octadecanoato-O)oxoaluminium | 236-521-7 | 13419-15-3 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Aluminum, benzoate C16-18 fatty acid complexes (CAS 94166-87-7) | 30/11/2015 | 14/01/2016 | Details | |
2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-octyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate | 248-227-6 | 27107-89-7 | Genetic toxicity in vivo | 30/11/2015 | 14/01/2016 | Details | |
[1,3(or 1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide | 246-678-3 | 25155-25-3 | Reproductive toxicity (pre-natal developmental toxicity) | 30/11/2015 | 14/01/2016 | Details | |
D-glucopyranose, oligomeric, C10-16 glycosides (even numbered), carboxymethyl ethers, sodium salts | 609-542-8 | 383178-66-3 | Reproductive toxicity (pre-natal developmental toxicity) | 30/11/2015 | 14/01/2016 | Details | |
Fats and Glyceridic oils, vegetable, winterized, reaction products with ammonia-ethanolamine reaction products | 800-253-4 | - |
Long-term toxicity to fish || Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates. Link to registration dossier not given as the dossier not yet disseminated. |
30/11/2015 | 14/01/2016 | Details | |
Hydrochloric acid, reaction products with aniline and nitrobenzene, sulfonated, sodium salts | 291-454-0 | 90411-76-0 | Reproductive toxicity (pre-natal developmental toxicity) | 30/11/2015 | 14/01/2016 | Details | |
N-{2-[(phenylcarbamoyl)amino]phenyl}benzenesulfonamide | 806-543-7 | 215917-77-4 | Genetic toxicity in vivo || Note: Testing proposal is based on concern identified by the registrant | 30/11/2015 | 14/01/2016 | Details | |
Reaction products of tryglycerides, C8-C18 (even numbered) and C18-unsaturated, glycerine and ethylene oxide | 939-459-5 | - | Sub-chronic toxicity (90-day): oral | 30/11/2015 | 14/01/2016 | Details | |
8,9,10-trinorborn-2-ene | 207-866-0 | 498-66-8 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (extended one-generation reproductive toxicity study) |
01/11/2015 01/11/2015 |
16/12/2015 16/12/2015 |
Details | |
Amines, polyethylenepoly-, tetraethylenepentamine fraction | 292-587-7 | 90640-66-7 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 01/11/2015 | 16/12/2015 | Details | |
N-vinylformamide | 236-102-9 | 13162-05-5 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 01/11/2015 | 16/12/2015 | Details | |
N,N'-ethane-1,2-diylbis(12-hydroxyoctadecan-1-amide) | 204-613-6 | 123-26-2 |
Sub-chronic toxicity (90 day): oral Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with: “Octadecanoic acid, 12-hydroxy-, reaction products with ethylenediamine”, CAS 100545-48-0 Long-term toxicity to fish || Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates |
30/09/2015 30/09/2015 30/09/2015 |
16/11/2015 16/11/2015 16/11/2015 |
Details | |
Poly[oxy(methyl-1,2-ethanediyl)], a-hydro-omega-hydroxy-, ether with 2,6 bis{[(2-hydroxyethyl)amino]methyl}-4-nonylphenol | 614-668-1 | 68610-97-9 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
30/09/2015 30/09/2015 |
16/11/2015 16/11/2015 |
Details | |
2,2'-[oxybis(methylene)]-bis[2-ethylpropane-1,3-diol] | 245-509-0 | 23235-61-2 | Sub-chronic toxicity (90-day): oral | 30/09/2015 | 16/11/2015 | Details | |
dihydro-3-(tripropenyl)furan-2,5-dione | 295-556-6 | 92077-08-2 | Reproductive toxicity (pre-natal developmental toxicity) | 30/09/2015 | 16/11/2015 | Details | |
sodium toluene-4-sulphonate | 211-522-5 | 657-84-1 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 30/09/2015 | 16/11/2015 | Details | |
tetraethylammonium hydroxide | 201-073-3 | 77-98-5 | Sub-chronic toxicity (90-day): oral || Note: testing proposed with N,N,N-trimethylmethanaminium chloride (EC 200-880-8; CAS 75-57-0) | 30/09/2015 | 16/11/2015 | Details | |
Esterification products of 4,4'-Isopropylidenediphenol, ethoxylated and prop-2-enoic acid and 3,5,5-trimethylhexanoic acide | 919-846-5 | - |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with an analogous substance |
31/08/2015 31/08/2015 |
15/10/2015 15/10/2015 |
Details | |
Tri(isopropyl)silyl acrylate | 457-670-6 | 157859-20-6 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
31/08/2015 31/08/2015 |
15/10/2015 15/10/2015 |
Details | |
Tri(isopropyl)silyl acrylate | 457-670-6 | 157859-20-6 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
31/08/2015 31/08/2015 |
15/10/2015 15/10/2015 |
Details | |
3-hydroxy-2-(3-hydroxy-2-quinolyl)-1H-inden-1-one | 241-753-7 | 17772-51-9 | Reproductive toxicity (pre-natal developmental toxicity) | 31/08/2015 | 15/10/2015 | Details | |
N,N'-(methylenedi-p-phenylene)bis[hexahydro-2-oxo-1H-azepine-1-carboxamide] | 258-981-8 | 54112-23-1 |
Long-term toxicity to fish Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates. |
31/08/2015 | 15/10/2015 | Details | |
trimethoxyoctylsilane | 221-338-7 | 3069-40-7 | Sub-chronic toxicity (90-day): oral || Note: testing proposed with triethoxy(2,4,4-trimethylpentyl)silane (CAS 35435-21-3) | 07/08/2015 | 22/09/2015 | Details | |
Urea, N-octyl-N'-[4-[[4-[[(octylamino)carbonyl]amino]phenyl]methyl]phenyl]-Urea, N-[4-[[4[(octadecylamino)carbonyl]amino]phenyl]methyl]phenyl]-N’-octyl | 445-760-8 | - |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
31/07/2015 31/07/2015 |
14/09/2015 14/09/2015 |
Details | |
1,1'-isopropylidenebis(p-phenyleneoxy)dipropan-2-ol | 204-137-9 | 116-37-0 | Reproductive toxicity (pre-natal developmental toxicity) | 31/07/2015 | 14/09/2015 | Details | |
Reaction mass of 1-(2,3-epoxypropoxy)-2,2-bis ((2,3-epoxypropoxy)methyl) butane and 1-(2,3-epoxypropoxy)-2-((2,3-epoxypropoxy)methyl)-2-hydroxymethyl butane | 608-489-8 | 30499-70-8 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
25/06/2015 25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 10/08/2015 |
Details | |
1,1,1,3,5,5,5-heptamethyltrisiloxane | 217-496-1 | 1873-88-7 |
Sub-chronic toxicity (90 day): inhalation
Note: testing proposed with 1,1,3,3-tetramethyldisiloxane, CAS 3277-26-7. Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with Octamethyltrisiloxane, CAS 107-51-7 and 1,1,3,3-tetramethyldisiloxane, CAS 3277-26-7 |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
1,1,3,3-tetramethyl-1,3-divinyldisiloxane | 220-099-6 | 2627-95-4 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
4-trans-Propyl-4-trans-vinyl-[1,1-bicylohexyl] | 601-409-2 | 116020-44-1 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
dichloro(diphenyl)silane | 201-251-0 | 80-10-4 |
Sub-chronic toxicity (90-day): oral Note: testing proposed with dimethoxy(diphenyl)silane (EC 229-929-1, CAS 6843-66-9) Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with dimethoxy(diphenyl)silane (EC 229-929-1, CAS 6843-66-9) |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
dimethoxydiphenylsilane | 229-929-1 | 6843-66-9 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
N-[3-(dimethoxymethylsilyl)-2-methylpropyl]ethylenediamine | 245-642-4 | 23410-40-4 |
Sub-chronic toxicity (90-day): oral Note: Testing proposal is based on concern identified by the registrant. Testing proposed with N-(3-(trimethoxysilyl)propyl)ethylenediamine (EC 217-164-6) Reproductive toxicity (pre-natal developmental toxicity) Note: Testing proposal is based on concern identified by the registrant. Testing proposed with N-(3-(trimethoxysilyl)propyl)ethylenediamine (EC 217-164-6) |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
N-[3-(dimethoxymethylsilyl)propyl]ethylenediamine | 221-336-6 | 3069-29-2 |
Sub-chronic toxicity (90-day): oral
Note: testing proposed with N-(3-trimethoxysilyl)propyl)ethylenediamine CAS 1760-24-3. Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with N-(3-trimethoxysilyl)propyl)ethylenediamine CAS 1760-24-3. |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
Reaction mass of 6-Amino-5-(4-substituted-sulfophenylazo)-1-hydroxy-2-[2-alkoxy-5-alkyl- (substitutedsulfonyl)-phenylazo]-naphthalene-sulfonic acid, potassium/sodium salt and 6-Amino-1-hydroxy-2-[2-alkoxy-5-alkyl- (substitutedsulfonyl)-phenylazo]-5-[sulfo- (substitutedsulfonyl)-phenylazo]-naphthalene-sulfonic acid, potassium/sodium salt | 445-040-3 | - |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
Reaction mass of [[(2-hydroxyethyl)imino]dimethylene]bisphosphonic acid, sodium salt and 4-(Phosphonomethyl)-2-hydroxy-2-oxo-1,4,2-oxazaphosphorinane, sodium salt | 939-513-8 | - |
Sub-chronic toxicity (90-day): oral Note: testing proposed either the registered substance or a read-across substance, which would be the acid form of the registered substance Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed either the registered substance or a read-across substance, which would be the acid form of the registered substance |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
trichloro(hexadecyl)silane | 227-575-2 | 5894-60-0 |
Sub-chronic toxicity (90-day): oral Note: testing proposed with hexadecyl(trimethoxy)silane (EC 240-464-3, CAS 16415-12-6) Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with hexadecyl(trimethoxy)silane (EC 240-464-3, CAS 16415-12-6) |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
Ureidopropyltrialkoxysilane | 449-160-7 | 116912-64-2 |
Sub-chronic toxicity (90-day): oral Reproductive toxicity (pre-natal developmental toxicity) |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
1,1'-dithiobis[hexahydro-2H-azepin-2-one] | 245-910-0 | 23847-08-7 | Reproductive toxicity (pre-natal developmental toxicity) | 25/06/2015 | 10/08/2015 | Details | |
A mixture of: cis-tetrahydro-2-isobutyl-4-methylpyran-4-ol; trans-tetrahydro-2-isobutyl-4-methylpyran-4-ol | 405-040-6 | 63500-71-0 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 25/06/2015 | 10/08/2015 | Details | |
Aluminum, benzoate C16-18-fatty acids complexes | 303-385-6 | 94166-87-7 | Reproductive toxicity (pre-natal developmental toxicity) | 25/06/2015 | 10/08/2015 | Details | |
butan-2-one O,O',O''-(vinylsilylidyne)trioxime | 218-747-8 | 2224-33-1 |
Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with Butan-2-one O,O',O''-(methylsilylidyne)trioxime (CAS 22984-54-9). |
25/06/2015 | 10/08/2015 | Details | |
dodecamethylpentasiloxane | 205-492-2 | 141-63-9 |
Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with Decamethyltetrasiloxane (EC 205-491-7). |
25/06/2015 | 10/08/2015 | Details | |
octyltrichlorosilane | 226-112-1 | 5283-66-9 | Sub-chronic toxicity (90-day): oral || Note: testing proposed with triethoxy(2,4,4-trimethylpentyl)silane (EC 252-558-1, CAS 35435-21-3) | 25/06/2015 | 10/08/2015 | Details | |
potassium 4-isopropylbenzenesulphonate | 629-764-9 | 164524-02-1 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 25/06/2015 | 10/08/2015 | Details | |
Reaction mass of sodium hydrogen N-(1-oxooctadecyl)-L-glutamate and stearic acid | 939-201-1 | - | Reproductive toxicity (pre-natal developmental toxicity) | 25/06/2015 | 10/08/2015 | Details | |
Sodium N-lauroylsarcosinate | 205-281-5 | 137-16-6 | Reproductive toxicity (pre-natal developmental toxicity) | 25/06/2015 | 10/08/2015 | Details | |
triethoxy(phenyl)silane | 212-305-8 | 780-69-8 |
Reproductive toxicity (pre-natal developmental toxicity) Note: testing proposed with trimethoxy(phenyl)silane (EC 221-066-9, CAS 2996-92-1) |
25/06/2015 | 10/08/2015 | Details | |
trimethoxy(2,4,4-trimethylpentyl)silane | 251-995-5 | 34396-03-7 |
Sub-chronic toxicity (90-day): oral
Note: testing proposed with triethoxy(2,4,4-trimethylpentyl)silane (EC 252-558-1, CAS 35435-21-3) " |
25/06/2015 | 10/08/2015 | Details | |
6'-(dibutylamino)-3'-methyl-2'-(phenylamino)spiro[isobenzofuran-1(3H),9-(9H)-xanthen]-3-one | 403-830-5 | 89331-94-2 | Bioaccumulation aquatic / sediment | 12/06/2015 | 27/07/2015 | Details | |