Ankstesni/Rezultatai
Ankstesni/Rezultatai
Ankstesni/Rezultatai
This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.
To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.
4,4'-methylenediphenyl diisocyanate and its oligomeric reaction products with oxydipropanol and [(methylethylene)bis(oxy)]dipropanol | 701-072-2 | - | Reproductive toxicity (extended one-generation reproductive toxicity study)|| Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC no: 202-966-0) | 16/06/2022 | 01/08/2022 | Details | |
4,4'-methylenediphenyl diisocyanate | 202-966-0 | 101-68-8 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 25/11/2021 | 10/01/2022 | Details | |
4,4'-methylenedi-2,6-xylenol | 226-378-9 | 5384-21-4 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 03/04/2023 | 22/05/2023 | Details | |
4,4'-methylenebis[N-sec-butylaniline] | 226-122-6 | 5285-60-9 | Bioaccumulation aquatic / sediment | 27/01/2020 | 12/03/2020 | Details | |
4,4'-methylenebis[N,N-bis(2,3-epoxypropyl)aniline] | 249-204-3 | 28768-32-3 |
Reproduction toxicity (two generation reproductive toxicity) Reproductive toxicity (developmental toxicity) Sub-chronic toxicity (90-day): dermal |
26/01/2011 26/01/2011 26/01/2011 |
14/03/2011 14/03/2011 14/03/2011 |
Details | |
4,4'-methylenebis[2,6-diethylaniline] | 237-185-4 | 13680-35-8 |
Genetic toxicity in vivo Long-term toxicity to fish |
26/03/2018 26/03/2018 |
11/05/2018 11/05/2018 |
Details | |
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with maleic anhydride and methacrylic acid | 500-090-6 | 36425-16-8 |
Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with a structurally related substance (small vinyl ester) Sub-chronic toxicity (90-day): oral || Note: testing proposed with a structurally related substance (small vinyl ester) |
31/05/2016 31/05/2016 |
15/07/2016 15/07/2016 |
Details | |
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with fatty acids, C18-unsatd., dimers | 500-180-5 | 67989-52-0 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
02/06/2014 02/06/2014 02/06/2014 |
17/07/2014 17/07/2014 17/07/2014 |
Details | |
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with 3-aminomethyl-3,5,5-trimethylcyclohexylamine | 500-101-4 | 38294-64-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/04/2014 15/04/2014 |
30/05/2014 30/05/2014 |
Details | |
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with 2-methylimidazole | 500-181-0 | 68002-42-6 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/09/2014 18/09/2014 |
03/11/2014 03/11/2014 |
Details | |
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, esters with acrylic acid | 500-130-2 | 55818-57-0 | Reproductive toxicity (pre-natal developmental toxicity) | 31/05/2016 | 15/07/2016 | Details | |
4,4'-Isopropylidenediphenol, ethoxylated, esters with fatty acids, coco | 500-303-2 | 115340-85-7 | Genetic toxicity in vivo | 21/01/2021 | 08/03/2021 | Details | |
4,4'-Isopropylidenediphenol, ethoxylated | 500-082-2 | - |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
21/05/2018 21/05/2018 21/05/2018 |
05/07/2018 05/07/2018 05/07/2018 |
Details | |
4,4'-Isopropylidenediphenol, ethoxylated | 500-082-2 | 32492-61-8 |
Genetic toxicity in vivo Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
16/06/2022 16/06/2022 16/06/2022 |
01/08/2022 01/08/2022 01/08/2022 |
Details | |
4,4'-Isopropylidenedicyclohexanol, oligomeric reaction products with 1-chloro-2,3-epoxypropane | 500-070-7 | 30583-72-3 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
02/06/2014 02/06/2014 02/06/2014 02/06/2014 |
17/07/2014 17/07/2014 17/07/2014 17/07/2014 |
Details | |
4,4'-isopropylidenedicyclohexanol | 201-244-2 | 80-04-6 | Long-term toxicity to fish | 17/06/2014 | 01/08/2014 | Details | |
4,4'-isopropylidenedicyclohexanol | 201-244-2 | 80-04-6 | Reproductive toxicity (pre-natal developmental toxicity) | 06/09/2018 | 22/10/2018 | Details | |
4,4'-isopropylidenedicyclohexanol | 201-244-2 | 80-04-6 | Genetic toxicity in vivo | 16/12/2020 | 01/02/2021 | Details | |
4,4'-isopropylidenedi-o-cresol | 201-240-0 | 79-97-0 | Genetic toxicity in vivo | 25/05/2020 | 09/07/2020 | Details | |
4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF | 216-036-7 | 1478-61-1 | Genetic toxicity in vivo | 23/11/2020 | 07/01/2021 | Details | |
4,4'-[(isopropylidene)bis(p-phenyleneoxy)]diphthalic dianhydride | 253-781-7 | 38103-06-9 | Sub-chronic toxicity (90-day): oral | 27/01/2020 | 12/03/2020 | Details | |
4,4'-(9H-fluoren-9-ylidene)bis(2-chloroaniline) | 407-560-9 | - |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
17/06/2020 17/06/2020 |
03/08/2020 03/08/2020 |
Details | |
4,4'-(9H-fluoren-9-ylidene)bis(2-chloroaniline) | 407-560-9 | 107934-68-9 | Bioaccumulation aquatic / sediment || Note: Testing proposal is based on concern identified by the registrant. | 16/10/2014 | 01/12/2014 | Details | |
4'-hydroxyacetophenone | 202-802-8 | 99-93-4 | Reproductive toxicity (pre-natal developmental toxicity) | 25/10/2017 | 11/12/2017 | Details | |
4'-Ethyl-2,3-difluorbiphenyl-4-boronic acid | 929-209-3 | - | Genetic toxicity in vivo | 16/12/2020 | 01/02/2021 | Details | |
3a,4,7,7a-tetrahydro-4,7-methanoindene | 201-052-9 | 77-73-6 | Reproductive toxicity (pre-natal developmental toxicity) | 28/02/2019 | 15/04/2019 | Details | |
3-{[3-(C10-16-oxy)propyl]amino}propan-1-aminium acetate | 941-152-6 | - | Sub-chronic toxicity (90-day): oral||Note: testing proposed with 1,3-propanediamine, N-[3-((C11-14, C13-rich)oxy)propyl]-branched acetate (EC: 931-295-2) | 15/07/2022 | 29/08/2022 | Details | |
3-trimethoxysilylpropyl methacrylate | 219-785-8 | 2530-85-0 |
Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): inhalation |
15/04/2011 15/04/2011 |
30/05/2011 30/05/2011 |
Details | |
3-trimethoxysilylpropyl methacrylate | 219-785-8 | 2530-85-0 | Reproductive toxicity (pre-natal developmental toxicity) | 26/04/2019 | 10/06/2019 | Details | |
3-trimethoxysilylpropyl methacrylate | 219-785-8 | 2530-85-0 |
Genetic toxicity in vivo Reproductive toxicity (extended one-generation reproductive toxicity study) |
01/09/2017 01/09/2017 |
16/10/2017 16/10/2017 |
Details | |
3-trimethoxysilylpropane-1-thiol | 224-588-5 | 4420-74-0 |
Reproductive toxicity (pre-natal developmental toxicity)
|| Note: testing proposed with 3-(triethoxysilyl)propanethiol (EC 238-883-1)
|| Note: Testing proposal is based on concern identified by the registrant. Sub-chronic toxicity (90-day): oral
|| Note: testing proposed with 3-(triethoxysilyl)propanethiol (EC 238-883-1)
|| Note: Testing proposal is based on concern identified by the registrant. |
23/11/2020 23/11/2020 |
07/01/2021 07/01/2021 |
Details | |
3-trimethoxysilylpropane-1-thiol | 224-588-5 | 4420-74-0 | Long-term toxicity to fish||Note: testing proposed with 3-Triethoxysilylpropane-1-thiol (EC no. 238-883-1) | 22/09/2022 | 07/11/2022 | Details | |
3-Sulfanylpropanoic acid | 203-537-0 | 107-96-0 |
Reproductive toxicity (developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) Sub-chronic toxicity (90-day): oral |
05/04/2011 05/04/2011 05/04/2011 |
20/05/2011 20/05/2011 20/05/2011 |
Details | |
3-Pentanone, 1,1,1,2,2,4,5,5-nonafluoro-4-(trifluoromethyl )- | 436-710-6 | 756-13-8 | Reproductive toxicity (pre-natal developmental toxicity) | 15/03/2011 | 29/04/2011 | Details | |
3-methylpentane-1,5-diol | 224-709-1 | 4457-71-0 | Long-term toxicity to fish | 01/03/2023 | 17/04/2023 | Details | |
3-methyldecane; benzene; cyclooctane; nonane | 941-364-9 | - | Reproductive toxicity (extended one-generation reproductive toxicity study) | 05/07/2018 | 20/08/2018 | Details | |
3-methylbutanone | 209-264-3 | 563-80-4 | Sub-chronic toxicity (90 day): inhalation | 14/08/2014 | 28/09/2014 | Details | |
3-methylbutan-1-ol | 204-633-5 | 123-51-3 | Long-term toxicity to fish||Note: testing proposed with Pentan-1-ol (EC no. 200-752-1) | 22/09/2022 | 07/11/2022 | Details | |
3-methoxy-3-methylbutan-1-ol | 260-252-4 | 56539-66-3 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 30/09/2021 | 15/11/2021 | Details | |
3-methoxy-3-methylbutan-1-ol | 260-252-4 | 56539-66-3 | Sub-chronic toxicity (90-day): oral | 18/09/2014 | 03/11/2014 | Details | |
3-methoxy-3-methylbutan-1-ol | 260-252-4 | 56539-66-3 | Long-term toxicity to fish | 26/10/2022 | 12/12/2022 | Details | |
3-mercaptopropionic acid | 203-537-0 | 107-96-0 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
04/09/2023 04/09/2023 |
19/10/2023 19/10/2023 |
Details | |
3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate, oligomers, reaction products with 2-butanone oxime | 500-287-7 | 103170-26-9 | Sub-chronic toxicity (90 day): inhalation | 12/12/2014 | 26/01/2015 | Details | |
3-hydroxy-2-(hydroxymethyl)-2-methylpropanal | 242-393-3 | 18516-18-2 |
Genetic toxicity in vivo Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
16/06/2011 16/06/2011 16/06/2011 16/06/2011 |
01/08/2011 01/08/2011 01/08/2011 01/08/2011 |
Details | |
3-hydroxy-2-(3-hydroxy-2-quinolyl)-1H-inden-1-one | 241-753-7 | 17772-51-9 | Reproductive toxicity (pre-natal developmental toxicity) | 31/08/2015 | 15/10/2015 | Details | |
3-hydroxy-2,2-dimethylpropyl 3-hydroxy-2,2-dimethylpropionate | 214-222-2 | 1115-20-4 |
Genetic toxicity in vivo Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
31/05/2011 31/05/2011 31/05/2011 |
15/07/2011 15/07/2011 15/07/2011 |
Details | |
3-hydroxy-1,1-dimethylbutyl 2-ethyl-2-methylheptaneperoxoate | 413-910-1 | 95718-78-8 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
17/04/2012 17/04/2012 17/04/2012 |
01/06/2012 01/06/2012 01/06/2012 |
Details | |
3-ethyloxetane-3-methanol | 221-254-0 | 3047-32-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
31/01/2014 31/01/2014 |
17/03/2014 17/03/2014 |
Details | |
3-ethyloxetane-3-methanol | 221-254-0 | 3047-32-3 | Long-term toxicity to fish | 03/10/2023 | 17/11/2023 | Details | |
3-Ethenyl-5-methyl-2-oxazolidinone | 809-852-5 | 3395-98-0 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
27/09/2017 27/09/2017 |
13/11/2017 13/11/2017 |
Details | |