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EC number: 603-837-5
CAS number: 134605-64-4
The study was performed to assess the acute inhalation
toxicity of the test material in the Sprague-Dawley strain of rat. The
study was performed to GLP and the method was designed to meet the
requirements of EPA guideline 81-3. Five males and five females
were exposed for four hours in a nose-only inhalation system to an
aerosol generated from the undiluted test material (fine powder) at a
level of 5.10 mg/L. A negative control using an additional five males
and five females was run concurrently. There was no mortality during the
Clinical signs included piloerection in both sexes of
test and control animals, and ptosis in one test male. There was no
meaningful effect on body weight gain, and all animals were asymptomatic
by Day 3. The gross necropsy revealed no observable abnormalities in any
of the animals on test. The acute inhalation LC50 for the test material
is greater than 5.10 mg/L.
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