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EC number: 603-837-5
CAS number: 134605-64-4
The study was performed to assess the acute dermal
toxicity of the test material in the Crl :CO®(SD)BR strain rat. The
study was performed to GLP and the method was designed to meet the
requirements of the EPA Guideline 81 -2.10 test animals (5 males and 5
females) were given a single, 24 -hour, semi-occluded dermal application
of the test material (slightly moistened using distilled water) to
intact skin at a dose of 2000 mg/kg body weight. Bodyweight development
were monitored during the study. All animals were subjected to gross
No signs of dermal irritation were noted. Animals showed
expected gains in bodyweight over the study period. No abnormalities
were noted at necropsy. Clinical signs were observed in 2 control males,
2 control females and 2 test females; these included: red-stained face,
wet and/or yellow-stained urogenital area, and soft stool. These four
animals returned to a normal appearance by Day 3 after treatment. The
acute dermal median lethal dose (LD50) of the test material in male and
female Crl :CO®(SD)BR rats was found to be greater than 2000 mg/kg
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