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EC number: 603-837-5
CAS number: 134605-64-4
The study was performed to assess the acute oral toxicity
of the test material in the Crl :CD®(SD)BR strain of rat. The study was
performed to GLP and the method was designed to meet the requirements
of EPA guideline 81-1. The test material was administered orally,
after overnight fasting, once only by gavage, as a suspension in MC/T 80
[0.5% methylcellulose (w/v) and 0.1% Tween 80 (v/v)]. The test material
concentration in the vehicle was 0.25 g/mL and the administered volume
of suspension was 20 mL/kg body weight. Following a preliminary test in
which an animal of each sex was dosed with the test material at 500,
1000, 3000 and 5000 mg/kg body weight, there was no mortality or signs
of systemic toxicity. For the main test, 10 male and 10 female test
animals were dosed at 0 and 5000 mg/kg body weight. Clinical signs and
bodyweight development were monitored during the study. All animals were
subjected to gross necropsy after an observation period of 14 days.
There were no deaths and no signs of systemic toxicity
were observed. Animals showed expected gains in bodyweight during the
study. No test-related abnormalities were noted at necropsy. The acute
oral median lethal dose (LD50) of the test material in the male and
female Crl:CD (SD) BR strain rat was estimated to be greater than 5000
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