1-(allyloxy)-2-methyl-1-oxopropan-2-yl 2-chloro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]benzoate

Bioaccumulation: aquatic / sediment

Description of key information

Calculated BCF values for the test material in the edible, non edible and whole fish were 1, 6 and 4 respectively, EPA OPP 165-4, OECD 305 & EPA 540/09-88-051, Volz 2000.

Key value for chemical safety assessment

BCF (aquatic species):

4 dimensionless

Additional information

Volz (2000) has been provided as the key study to address bioaccumulation of the test material in fish. The bioaccumulation and elimination of the test material was determined in an uptake and depuration study conducted with Bluegill sunfish (Lepomis macrochirus).

Stable steady-state was reached in fish within about one (higher concentration) and three weeks for the higher (0.03 mg/L) and lower (0.003 mg/L) concentration, respectively. Measured bioconcentration factors (as a mean of the lower and the higher concentration) for radiolabelled test material residues in non-edible portions, edible portions and whole fish were 114, 5 and 63, respectively. Furthermore the calculated BCFs (as a mean of the lower and the higher concentration, again) for the same tissues were 111, 5 and 62, respectively. Bioconcentration factors were calculated for parent and metabolite No. 1), based on the metabolite pattern in fish tissues at day 34 of the accumulation. The bioconcentration factors for the parent in non-edible portions, edible portions and the whole fish were 6, 1 and 4, for the lower, and 6, 1 and 4 for the higher concentrations, respectively. Thus, the mean BCF for the parent is 4 for the whole fish. The bioconcentration factors for metabolite No. 1 in non-edible portions, edible portions and the whole fish were 74, 2 and 39, for the lower, and 68, 3 and 39 for the higher concentration, respectively. Thus, the mean BCF for metabolite No. 1 is 39 for the whole fish. After termination of exposure, test material residues were rapidly eliminated from the non-edible and edible tissues and the whole fish. The depuration time for 90 % of the bioconcentrated radioactivity for the whole fish was less than 2 days. Under the conditions of the test, the test material showed only limited bioconcentration in bluegill fish, and bioconcentrated residues were rapidly eliminated in untreated water.

 

The study was performed to a high standard, in line with GLP and in accordance with standardised guidelines and has thus been assigned a reliability score of 1 in line with the principles for assessing data quality set out in Klimisch (1997).

 

The available data are considered to be complete and the conclusion that the test material has a BCF value of 4 for the whole fish has been taken forward for risk assessment.