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EC number: 603-837-5
CAS number: 134605-64-4
Freshwater: NOEC 0.009 mg/L, LOEC 0.018 mg/L, life-cycle toxicity, Daphnia magna, EPA OPP 72-4, EPA 540/9-86-141, ASTM E1193-87, Roberts & Swigert 1997 Marine Study:No data available
The long-term toxicity to aquatic invertebrates was determined in a
life-cycle toxicity study performed using Daphnia magna. The test
was conducted in line with GLP and in accordance with the standardised
guidelines EPA OPP 72-4, EPA 540/9-86-141 and ASTM E1193-87. Daphnids
were exposed to the test material at measured concentrations of 0.009,
0.018, 0.036, 0.07 and 0.13 mg a.i./L under flow-through freshwater
conditions for 21 days. Survival, clinical signs, reproduction and
growth were monitored in adults and offspring to determine the acute
Under the conditions of the test, growth was shown to be the most
sensitive biological parameter to exposure of the test material. A
statistically significant (p<0.05) reduction in mean dry weight was
observed at 0.018 mg a.i./L. At concentrations ≥ 0.036 mg a.i./L growth
was shown to decline with increasing concentration, however as survival
was affected at these concentrations, these values could not be included
in the statistical analyses for growth. Based on growth data the LOEC
was determined to be 0.018 mg a.i./L and the NOEC was determined to be
0.009 mg a.i./L. Reproductive performance was shown to be affected at
concentrations ≥0.036 mg a.i./L but the results from the 0.009 and 0.018
mg a.i./L treatment groups was not statistically significant to the
pooled controls. Statistical analysis could not be performed on higher
concentrations due to significant effects on adult survival but the
observed response suggests a treatment-related response on reproduction.
Percentage mortality was statistically different (p<0.05) from the
pooled controls at 0.036, 0.07 and 0.13 mg a.i./L, where mortality
reached 39, 79 and 86%, respectively. Based on mortality data alone, the
NOEC was determined to be 0.018 mg a.i./L and the LOEC was determined to
be 0.036 mg a.i./L.
Based on the most sensitive data the overall NOEC and LOEC for toxicity
during a life-cycle toxicity test were determined to be 0.009 and 0.018
mg a.i./L, respectively. The maximum acceptable toxicant concentration
was determined to be 0.013 mg a.i./L, calculated as the geometric mean
of the NOEC and LOEC.
The study was performed to a high standard, in line with GLP and
standardised guidelines. Accordingly the study has been assigned a
reliability score of 1 in line with principles for assessing data
quality set out in Klimisch (1997). The available data are deemed to be
relevant, reliable and adequate for the purposes of risk assessment.
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