Support by accredited stakeholders

This page offers web links to tools, information and guidance that are publically available and free of charge. They have been provided by ECHA's accredited stakeholders, and are published with the aim to facilitate the implementation of European chemicals legislation.

Linking to other websites should not be taken as an endorsement of any kind by ECHA. If you access another site through one of these links you are subject to the privacy policy of that site. For further information see ECHA's Legal Notice.

AISE
International Association for Soaps, Detergents and Maintenance Products
REACH implementation and communication support
CEFIC
European Chemical Industry Council
CEPE
European Council of the Paint, Printing Ink and Artists' Colours Industry
Use descriptors, risk management measures and specific environmental release categories
ChemSec
International Chemical Secretariat
Support for the substitution of hazardous chemicals
CONCAWE
Conservation of Clean Air and Water in Europe
ECETOC
European Centre for Ecotoxicology and Toxicology of Chemicals
Tool for worker exposure assessment models
ECI
European Copper Institute
ECPA
European Crop Protection Association
Tools for REACH requirements in plant protection
EDANA
The international association for the nonwovens and related industries
EUROALLIAGES
Association of European ferro-Alloy producers
Information for ferro-alloys and silicon producers
EUROFER
The European Steel Association
REACH information, helpdesk and data sharing forum
Eurometaux
European Association of Metals
REACH and CLP support
FEA
European Aerosol Federation
Tool to predict indoor aerosol concentration
FECC
European Association of Chemical Distributors
Safety, Health and Environment Committee
FEICA
Association of European Adhesives and Sealants Manufacturers
Use descriptors
NIA
Nanotechnology Industries Association
Nano safety assessment projects
PISC
Peta International Science Consortium, Ltd.
Webinar 1: Perspectives on the Development, Evaluation, and Application of in Silico Approaches for Predicting Toxicity
Date:
25 January 2018
Speakers:
Dr. Grace Patlewicz, U.S. EPA
Professor Mark Cronin, Liverpool John Moores University
Description:
Dr Patlewicz and Professor Cronin discuss the QSARs that can be used to meet regulatory testing requirements under REACH. The use of read-across is presented – emphasising both the availability of different frameworks for the development of read-across and frameworks for the assessment and evaluation of read-across justification – highlighting examples published in the literature as well as regulatory technical guidance (OECD, ECHA). Tools that can help facilitate the development of read-across, including the OECD QSAR Toolbox, are outlined. Attention is drawn to ongoing research that is evolving the way in which read-across approaches can be undertaken, including by exploiting the use of high-throughput screening data such as those generated under the US EPA's ToxCast programme. The use of read-across and QSARs is framed in the context of integrated approaches to testing and assessment (IATA). Examples highlight how some IATA have evolved, particularly in the arena of skin sensitisation, where defined approaches have been developed. These formalise the use of certain non-animal test methods that characterise the key events within the associated adverse outcome pathway.

 

Webinar 2: Skin irritation and corrosion
Date:
1 February 2018
Speakers:
Dr. Gertrude-Emilia Costin, Institute for In Vitro Sciences
Dr. Costanza Rovida, TEAM Mastery and CAAT Europe
Description:
Dr. Costin will describe the in vitro methods that can be used to meet REACH data requirements for skin irritation and corrosion under Annexes VII and VIII. Dr. Rovida will use specific examples to explain how the in vitro methods can be used in an integrated approach to testing and assessment.

 

Webinar 3: Eye irritation and Corrosion
Date:
15 February 2018
Speakers:
Dr. Kim Norman, Burt's Bees
Dr. Els Adriaens, Ghent University
Description:
Drs. Norman and Dr. Adriaens will first discuss the drivers of in vivo classification for serious eye damage and eye irritation in order to specify the requirements for achieving full replacement of the regulatory animal test. They will then describe the available in vitro methods and the ways in which they can be used alone or in combination in various testing strategies, such as top-down or bottom-up approaches.

 

Webinar 4: 3R approach to acute oral toxicity
Speakers:
Dr Kimmo Louekari, ECHA
Description:
Dr. Louekari presents on 3R approaches to acute oral toxicity testing. He describes an approach that includes waiving such testing when subacute oral toxicity data indicate low toxicity and an enhanced dose-range finding study, or in vitro 3T3 neutral red uptake cytotoxicity test, are provided in the context of the weight-of-evidence approach.

 

Archive (2014-2015 webinar series): alternative approaches to mammalian acute systemic toxicity testing
Date:
March 5, 2015
11am - 12pm US EST      4pm - 5pm GMT
Speakers:
Dr Pilar Prieto, EURL ECVAM Dr Lawrence Milchak, 3M
Description:
Dr Pilar Prieto will present on EURL ECVAM's recently released strategy to replace, reduce and refine the use of animals in the assessment of acute mammalian systemic toxicity. The strategy highlights the importance of developing adverse outcome pathways (AOPs) and integrated approaches to testing and assessment (IATA) related to acute systemic toxicity. It also discusses improvements in the predictability of the 3T3 NRU assay, development of additional in vitro and in silico approaches, waiving acute toxicity testing based on e.g., repeated dose data, refinement of in vivo studies, and provides a framework for prioritising the alternative methods that have been submitted to EURL ECVAM for validation. Following Dr Prieto's talk, Dr Lawrence Milchak from 3M will speak to industry experiences on the use of alternative strategies to meet acute toxicity testing requirements.

 

Archive (2014-2015 webinar series): (zebra)fish embryo acute toxicity test to predict short term toxicity to fish (and beyond)
Date:
April 14, 2015
11am - 12pm US EST      4pm - 5pm GMT
Speakers:
Marlies Halder, EURL ECVAM Thomas Braunbeck, Unviersity of Heidelberg Scott Belanger, Procter & Gamble
Description:
In this webinar, Dr Halder will begin by describing the REACH data requirements for short term toxicity testing on fish and the OECD acute fish toxicity test (OECD TG 203). She will then describe the Fish Embryo Acute Toxicity Test (FET), which was adopted by the OECD in 2013 as Test Guideline 236 and is recommended by the European Union Reference Laboratory for Alternatives to Animal Testing as a possible alternative to the acute fish toxicity test. Dr Belanger will provide an assessment of the correlation between the OECD acute fish toxicity test and the fish embryo toxicity test. This will include an assessment of the domain of applicability and the possibility of using the FET in traditional fish Quantitative Structure Activity Relationships.  Prof. Braunbeck will then describe the potential use of fish embryos beyond acute fish toxicity testing and provide a view to potential future uses of fish embryos in a much wider array of environmental science and human health applications.

 

 

Archive (2014-2015 webinar series): regulatory processes involved in acceptance of non-animal tests
Date:
10 June, 2015
3pm - 4pm BST
Speakers:
Derek Knight, ECHA and Karin Kilian, European Commission
Description:
Derek Knight, Senior Scientific Advisor, ECHA, will speak about regulatory acceptance from a scientific and procedural point of view. Karin Kilian, Policy Officer, European Commission, DG ENVIRONMENT,Unit A.3, Chemicals, will explain the process for incorporating validated tests into the EU Test Methods Regulation. She will also give a brief history of it and how it relates to REACH/CLP and other EU chemicals laws. Finally, she will present a timeline for updates of the Regulation.

 

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