Registration Dossier

Administrative data

Endpoint:
carcinogenicity
Remarks:
intraperitoneal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Title:
No information
Author:
Herren-Freund, S.L., Pereira, M.A. (1986): Environ. Health|Perspect. 69, 59 - 65

Materials and methods

Principles of method if other than guideline:
Migrated dataset. 1,2,3- Trichlorobenzene was tested for initiating and/or promoting activity in rat liver by using rat liver foci bioassay (see freetext)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: other TS: 1,2,3-trichlorobenzene purity: no data

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Duration of treatment / exposure:
see Method
Frequency of treatment:
see Method
Doses / concentrations
Remarks:
Doses / Concentrations:
1mmol/kg bw (181.6 mg/kg bw)
Basis:

Control animals:
other: yes, positive control: phenobarbital
Details on study design:
Post-exposure period: see Method

Results and discussion

Any other information on results incl. tables

Migrated dataset. RS-Freetext:
1.2.3-trichlorobenzene does not promote the DENA-initiated
GGT foci either in male or female rats.

Applicant's summary and conclusion