Registration Dossier

Administrative data

Endpoint:
repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Title:
No information
Author:
Zub M (1978). Reactivity of the white blood cell system to toxic action benzene and its derivatives. Acta Biol. 21, 163-174

Materials and methods

Principles of method if other than guideline:
Method: other: 5 mice/sex, whole-body exposure
GLP compliance:
no
Remarks:
GLP was not mandatory at the time of the study

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: other TS: Trichlorobenzene isomere not specified, no data on purity

Test animals

Species:
mouse
Strain:
Swiss
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Duration of treatment / exposure:
3 weeks, 3 months
Frequency of treatment:
daily, 7 hours
Doses / concentrations
Remarks:
Doses / Concentrations:
3 weeks: 500 mg/m³, 3 months: 20 mg/m³
Basis:

Control animals:
yes, concurrent no treatment
Details on study design:
Post-exposure period: no data

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Migrated dataset. RS-Freetext:
3-weeks exposure:
all animals survived, hypoactivity, lack of appetite, matted hair 
Leukopenia, lymphocytosis in the peripheral blood, fatty degeneration in  the liver

3 months exposure:
body weight loss, matted hair, drowsiness,
Leukopenia, lymphocytosis, neutropenia, degenerative changes in the  thymus,intense desintegration of lymphocytes

Applicant's summary and conclusion