Registration Dossier

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986

Materials and methods

Principles of method if other than guideline:
Hydrolysis rates were measured under sterile conditions at precisely controlled temperatures and at three pH levels (3, 7 and 11). Chemical concentration (1,2,3-TCB) as a function of incubation time were measured by gas chromatography.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Study design

Buffers:
- pH: 3
- Composition of buffer: 0.005 M potassium hydrogen phthalate and final pH adjustment made with 0.1 HCl
- pH: 7
- Composition of buffer: 0.005 M potassium dihydrogen phoshate and final pH adjustment made with 0.1 NaOH
- pH: 9 and 11
- Composition of buffer: 0.005 M sodium phosphate heptahydrate and final pH adjustment made with 0.1 NaOH

Results and discussion

Any other information on results incl. tables

 Hydrolysis and Analysis Data (1,2,3-trichlorobenzene)

 

pH

Temp [°C]

10³ K1[hr-1]

T ½ [d]

r ²

3.03

68.0

7.80

3.7

0.755

3.08

70.0

0.79

36.6

0.420

3.07

70.0

1.50

19.2

0.933

3.07

70.0

0.88

32.8

0.691

6.99

68.8

3.28

8.8

0.688

7.13

70.0

0.80

16.1

0.740

7.13

70.0

1.93

15.5

0.867

7.10

70.0

1.90

15.2

0.691

10.70

68.0

3.81

7.6

0.533

9.80

70.0

0.84

34.4

0.626

9.74

70.0

3.0

9.6

0.603

Applicant's summary and conclusion