Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-757-1 | CAS number: 87-61-6
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment (small number of animals, treatment time rather short, only the max dose given, only high dose results reported Thus no dose-effect relationship can be derived).
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- Giddings M. et al. (1994). Evaluation of risks to health from environmental exposure in Canada. Environm. Carcino.Ecotox. Revs. C12, 517-525
- Title:
- No information
- Author:
- Rimmington C and G Ziegler (1963). Experimental porphyria in rats induced by chlorinated benzenes. Biochem. Pharmacol. 12, 1387-1397
Materials and methods
- Principles of method if other than guideline:
- Method: other: 3 rats, gradually increased dosing, only maximum dose reported, urinary porphyrins, porphobilinogen and delta- aminolaevulic acid were determined in 24-hours samples, liver examined Controls: solvent, Allylisopropylacetamid, Sed
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,2,3-trichlorobenzene
- EC Number:
- 201-757-1
- EC Name:
- 1,2,3-trichlorobenzene
- Cas Number:
- 87-61-6
- Molecular formula:
- C6H3Cl3
- IUPAC Name:
- 1,2,3-trichlorobenzene
- Details on test material:
- IUCLID4 Test substance: other TS: 1,2,3-trichlorobenzene, no data on purity
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- 7 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
up to 785 mg/kg bw (max. dose) dissolved in 1% celofas
Basis:
- Control animals:
- yes
- Details on study design:
- Post-exposure period: no
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
Urinary porphyrins and porphyrin percursers were the first apparent sign of intoxication:
max dose: 785 mg/kg bw versus solvent control:
36.59 versus 4.3-6.8 µg/day Coproporphyrin,
0.72 versus 0.1-0.3 µg/day uroporphyrin,
57.38 versus 2.5-6.5 µg/day porphobilinogen,
36.26 versus 38.7-51.6 µg/day delta-aminolaevulic acid
clinical signs:
weight loss, extreme weakness, ataxia, clonic contractions, slight tremor
liver examination:
degeneration of individual liver cells without actual necrosis, or small areas showing focal necrosis in the central midzonal and periportal region
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
