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EC number: 201-757-1 | CAS number: 87-61-6
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment (small number of animals, treatment time rather short, only the max dose given, only high dose results reported Thus no dose-effect relationship can be derived).
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- Giddings M. et al. (1994). Evaluation of risks to health from environmental exposure in Canada. Environm. Carcino.Ecotox. Revs. C12, 517-525
- Title:
- No information
- Author:
- Rimmington C and G Ziegler (1963). Experimental porphyria in rats induced by chlorinated benzenes. Biochem. Pharmacol. 12, 1387-1397
Materials and methods
- Principles of method if other than guideline:
- Method: other: 3 rats, gradually increased dosing, only maximum dose reported, urinary porphyrins, porphobilinogen and delta- aminolaevulic acid were determined in 24-hours samples, liver examined Controls: solvent, Allylisopropylacetamid, Sed
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,2,3-trichlorobenzene
- EC Number:
- 201-757-1
- EC Name:
- 1,2,3-trichlorobenzene
- Cas Number:
- 87-61-6
- Molecular formula:
- C6H3Cl3
- IUPAC Name:
- 1,2,3-trichlorobenzene
- Details on test material:
- IUCLID4 Test substance: other TS: 1,2,3-trichlorobenzene, no data on purity
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- 7 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
up to 785 mg/kg bw (max. dose) dissolved in 1% celofas
Basis:
- Control animals:
- yes
- Details on study design:
- Post-exposure period: no
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
Urinary porphyrins and porphyrin percursers were the first apparent sign of intoxication:
max dose: 785 mg/kg bw versus solvent control:
36.59 versus 4.3-6.8 µg/day Coproporphyrin,
0.72 versus 0.1-0.3 µg/day uroporphyrin,
57.38 versus 2.5-6.5 µg/day porphobilinogen,
36.26 versus 38.7-51.6 µg/day delta-aminolaevulic acid
clinical signs:
weight loss, extreme weakness, ataxia, clonic contractions, slight tremor
liver examination:
degeneration of individual liver cells without actual necrosis, or small areas showing focal necrosis in the central midzonal and periportal region
Applicant's summary and conclusion
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