Registration Dossier
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EC number: 201-757-1 | CAS number: 87-61-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report Date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Analytical purity not reported. No GLP. Observation time too short
- GLP compliance:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): 1,2,3- trichlorobenzene (solidified melted)
- Physical state: solid
-Analytical purity: no data
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Hacking & Churchill ltd., Huntingdon, UK
- Weight at study initiation: 3 kg
- Diet (e.g. ad libitum): Futter "Ssniff K4" (Ssniff Versuchstierdiaten GmbH, Soest/Westf., Germany) ad libitum
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-21°C Celsius
- Humidity (%): 40-50%
- Photoperiod (hrs dark / hrs light): 12 hrs dark / 12 hrs ligh (7 a.m.-7 p.m.)
IN-LIFE DATES: The test was conducted during April 1982
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: test subtance was prepared as a paste with water
- Controls:
- other: the untreated site served as control
- Amount / concentration applied:
- Concentration: 500 mg
- Duration of treatment / exposure:
- 4 hour(s)
- Observation period:
- 1, 24, 48 and 72 hours, 7 days
- Number of animals:
- 3
- Details on study design:
- The flank skin of the three animals was shaved on both sides with electric cutter on an area of about 6x6 cm (24 h before testing the intact skin)
0.5 g of the substance mixed with water was applied on a gauze patch (2.5x2.5 cm).
The exposure time lasted 4h, then the patches were removed and the exposed area was washed with water.
SCORING SYSTEM: accoring to DRAIZE
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24, 48, and 72 hours
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24, 48, and 72 hours
- Score:
- 0.3
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 24, 48, and 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24, 48, and 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24, 48, and 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 24, 48, and 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- Additional symptoms were not observed
Any other information on results incl. tables
Evaluation results of skin reactions after 1,2,3-trichlorobenzene administration to rabbits
Readings | Animal | Erythema | Edema |
24 h | 68 | 0 | 0 |
24 h | 69 | 0 | 0 |
24 h | 70 | 1 | 0 |
48 h | 68 | 0 | 0 |
48 h | 69 | 0 | 0 |
48 h | 70 | 1 | 0 |
72 h | 68 | 0 | 0 |
72 h | 69 | 0 | 0 |
72h | 70 | 0 | 0 |
Mean24 -72h | 68 | 0.3 | 0 |
Mean24 -72h | 69 | 0.3 | 0 |
Mean24 -72h | 70 | 0 | 0 |
Total mean |
| 0.2 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
Suberg H (1982)
An acute dermal irritation/corrosion study was conducted according OECD Guideline 404 with deviations (Analytical purity not reported. No GLP. Observation time too short).
3 New Zealand White rabbits were exposed to 0.5 g 1,2,3 -trichlorobenzene for 24 hours. Observation time points were 1h, 24h, 48, 72h and 7 days after removal of the patch.
The mean erythema score at 24-72h after exposure was 0.3 for 2/3 of the animals tested. The oedema score between was found to have a value of 0 at 24 -72h after exposure.
On the basis of the data obtained 1,2,3-trichlorobenzene can not be classified as irritant.
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