Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-757-1 | CAS number: 87-61-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Analytical purity not reported. No GLP. Observation time too short
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,2,3-trichlorobenzene
- EC Number:
- 201-757-1
- EC Name:
- 1,2,3-trichlorobenzene
- Cas Number:
- 87-61-6
- Molecular formula:
- C6H3Cl3
- IUPAC Name:
- 1,2,3-trichlorobenzene
- Details on test material:
- - Name of test material (as cited in study report): 1,2,3- trichlorobenzene (solidified melted)
- Physical state: solid
-Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hacking & Churchill ltd., Huntingdon, UK
- Weight at study initiation: 3 kg
- Diet (e.g. ad libitum): Futter "Ssniff K4" (Ssniff Versuchstierdiaten GmbH, Soest/Westf., Germany) ad libitum
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-21°C Celsius
- Humidity (%): 40-50%
- Photoperiod (hrs dark / hrs light): 12 hrs dark / 12 hrs ligh (7 a.m.-7 p.m.)
IN-LIFE DATES: The test was conducted during April 1982
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: test subtance was prepared as a paste with water
- Controls:
- other: the untreated site served as control
- Amount / concentration applied:
- Concentration: 500 mg
- Duration of treatment / exposure:
- 4 hour(s)
- Observation period:
- 1, 24, 48 and 72 hours, 7 days
- Number of animals:
- 3
- Details on study design:
- The flank skin of the three animals was shaved on both sides with electric cutter on an area of about 6x6 cm (24 h before testing the intact skin)
0.5 g of the substance mixed with water was applied on a gauze patch (2.5x2.5 cm).
The exposure time lasted 4h, then the patches were removed and the exposed area was washed with water.
SCORING SYSTEM: accoring to DRAIZE
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24, 48, and 72 hours
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24, 48, and 72 hours
- Score:
- 0.3
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 24, 48, and 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24, 48, and 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24, 48, and 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 24, 48, and 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- Additional symptoms were not observed
Any other information on results incl. tables
Evaluation results of skin reactions after 1,2,3-trichlorobenzene administration to rabbits
Readings |
Animal |
Erythema |
Edema |
24 h |
68 |
0 |
0 |
24 h |
69 |
0 |
0 |
24 h |
70 |
1 |
0 |
48 h |
68 |
0 |
0 |
48 h |
69 |
0 |
0 |
48 h |
70 |
1 |
0 |
72 h |
68 |
0 |
0 |
72 h |
69 |
0 |
0 |
72h |
70 |
0 |
0 |
Mean24 -72h |
68 |
0.3 |
0 |
Mean24 -72h |
69 |
0.3 |
0 |
Mean24 -72h |
70 |
0 |
0 |
Total mean |
|
0.2 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
Suberg H (1982)
An acute dermal irritation/corrosion study was conducted according OECD Guideline 404 with deviations (Analytical purity not reported. No GLP. Observation time too short).
3 New Zealand White rabbits were exposed to 0.5 g 1,2,3 -trichlorobenzene for 24 hours. Observation time points were 1h, 24h, 48, 72h and 7 days after removal of the patch.
The mean erythema score at 24-72h after exposure was 0.3 for 2/3 of the animals tested. The oedema score between was found to have a value of 0 at 24 -72h after exposure.
On the basis of the data obtained 1,2,3-trichlorobenzene can not be classified as irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.