1,2,3-trichlorobenzene

Specific investigations: other studies

Administrative data

Endpoint:

cytotoxicity

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Documentation insufficient for assessment

Data source

Reference

Title:

No information

Author:

Fratello G. et al. (1997). Cytotoxicity of halogenated benzenes and its relationship with logP. Toxicology in Vitro 11, 673-677

Materials and methods

Principles of method if other than guideline:

The in vitro toxicity of a series of environmentally relevant halobenzenes was tested using a Chinese hamster lung fibroblast cell line and its relationship with the logarithm of octanol/water partition coefficient (logP) was investigated. Colony ability forming (CFA) was performed and the DNA demage was analyses by cytofluorimetric assay.

GLP compliance:

not specified

Type of method:

in vitro

Test material

Test material information

Constituent 1

Reference substance name:

1,2,3-trichlorobenzene

EC Number:

201-757-1

EC Name:

1,2,3-trichlorobenzene

Cas Number:

87-61-6

Molecular formula:

C6H3Cl3

IUPAC Name:

1,2,3-trichlorobenzene

Results and discussion

Any other information on results incl. tables

There was a dose dependent increase in inhibition of NRU uptake from 0 % inhibition at 0.0001 mg/ml up to 92 % at 1 mg/ml. Colony-forming ability (CFA) test  was performed with V79 Chinese hamster lung cells that were treated with  0.075, 0.05, 0.025, 0.01 mg/ml for 24 hours (incubation time) and the  concentration that inhibited the CFA by 50 % was derived:  IC50 = 0.24 mM