1,2,3-trichlorobenzene

Bioaccumulation: aquatic / sediment

Administrative data

Endpoint:

bioaccumulation in aquatic species, other

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

other: Applicant's summary entry

Rationale for reliability incl. deficiencies:

other: no reliability is given as this is an applicant's summary entry

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1992

Reference 2

Reference Type:

publication

Title:

Bioconcentration of Chlorobenzenes from Water by Rainbow Trout: Correlations with Partition Coefficients and Environmentral Residues

Author:

Oliver and Niimi

Year:

1983

Bibliographic source:

Environ. Sci. Technol., Vol. 17, No. 5, 287-291

Reference 3

Reference Type:

publication

Title:

Bioconcentration factors and kinetics of chlorobenzenes in a Juvenile Crab (Portunus pelagicus)

Author:

Mortimer M

Year:

1993

Bibliographic source:

Aust. J. Mar. Freshwater Res., 44,565-76

Reference 4

Reference Type:

publication

Title:

Partition Coefficients of organic compounds in lipid-water systems and correlations with fish bioconcentration factors

Author:

Chiou CT

Year:

1995

Bibliographic source:

Environ. Sci. Technol., Vol. 19, No. 1, pp. 57-62

Reference 5

Reference Type:

publication

Title:

Toxicokinetics of chlorobenzenes in fish

Author:

van Hoogen G, Opperhuizen A

Year:

1988

Bibliographic source:

Environ. Toxicol. Chem. 7(3), pp.213-219

Reference 6

Reference Type:

secondary source

Title:

Comparison of BCF models based on log P

Author:

Devillers J

Year:

1996

Bibliographic source:

Chemosphere, Vol. 33, No. 6 pp. 1047-1065

Reference 7

Reference Type:

publication

Title:

Biotransformation and toxicokinetics of trichloroanilines in fish in relation to their hydrophobicity

Author:

de Wolf et al.

Year:

1993

Bibliographic source:

Arch. Environ. Contam.Toxicol. 25, 110-117

Reference 8

Reference Type:

publication

Title:

Relationship between bioavailability and hydrophobicity: reduction of the uptake of organic chemicals by fish due to the sorption on particles

Author:

Schrap SM and Opperhuizen A

Year:

1990

Bibliographic source:

Environ. Toxicol. Chem. 9, 715-724

Materials and methods

Principles of method if other than guideline:

Applicant's summary entry

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

1,2,3-trichlorobenzene

EC Number:

201-757-1

EC Name:

1,2,3-trichlorobenzene

Cas Number:

87-61-6

Molecular formula:

C6H3Cl3

IUPAC Name:

1,2,3-trichlorobenzene

Results and discussion

Any other information on results incl. tables

Applicant's summary entry:

 

The log Kow is >3 indicating that bioconcentration in aquatic organisms may occur. In a number of bioaccumulation studies, the bioconcentration factor values (BCF) observed in fish ranged from 130 (MITI, 1992) to 2600 (Oliver and Niimi, 1983) to 12484 (Mortimer M,1993)

 

Oliver and Niiml (1983)

The rainbow trout exposed for 119 days in a flow through system at 4.3 ng/l showed a bioconcentration factor of 1200 while exposed to water containing 72 ng/l for 105 days showed a BCF of 2600 (Oliver and Niimi, 1983). The concentration level (ng/l) was chosen as this concentration was observed in water and effluents of the Great Lakes in.

(The BCF at the high- exposure level averaged 2.2 times higher than that at the low-exposure levels for all chemicals.)

 

 

Mortimer M (1993)

The uptake- and depuration-rate constants (k1, k2), according to first-order kinetics, were measured for a series of chlorobenzenes with juvenile crabs. The bioconcentration factor KB (KB in wet weight units) obtained from these rate constants.

1,2,3-trichlorobenzene: D (Calculated on a lipid basis BL)

Bioconcentration factor D : log KBL = 4.10 (KBL = 12484)  

Uptake-rate-constant D: k1 = 1910 1/h

Depuration-rate-constant : k2 = 0.153 1/h

 

Chiou CT (1985)

The Triolein-water partition coefficients (Ktw) have been determined. A comparison of log Ktw values with corresponding log (BFC) values reported by Könemann and van Leeuween with guppies (log BFC = 4.11; BFC =12882), and by Oliver and Nimi with rainbow trout (log BFC = 4.15 - 4.47 (BFC =14125 - 29512), expressed in the basis of the fish lipid content. Results show a close agreement between Ktw und BCF values for the compounds studied.

 

van Hoogen G, Opperhuizen A (1988)

Uptake and elimination rate constants measured in the bioconcentration experiments. Uptake rate constants were estimated from the increase in the concentration in fish after initial exposure, and elimination rate constants were calculated from the decreasing concentration in fish after they were transferred to clean water. Bioconcentration factors were calculated as the ratio between the uptake and elimination rate constants ( Kc = K1/k2).

K1 [ml/g d] = 780 +/- 220                             t 90% [d] a = 5.4

K2 [1/d] = 0.42 +/-0.06                                c f (4d) [%] b = 81

Kc [ml/g] = 1900

a         Time at which 90% of the theoretical steady- state concentration in fish is reached.

b         Concentration on fish after 4 d of accumulation, express as percentage of the theoretical steady-state concentration.

 

Devillers J. (1996) reported:

All values calculated on lipid content basis.

 

de Wolf et al. 1983: log BFC = 2.90 Poecilia reticluata (BFC=794)
Oliver , Niimi 1983: log BFC =3.08 Oncorhynchus mykiss (BFC=1202)
Schrap and Opperhuizen 1990: log BFC = 3.28 Poecilia reticluata (BFC=1905)
Oliver , Niimi 1983: log BFC =3.26 Oncorhynchus mykiss (BFC=1819)