Registration Dossier

Administrative data

Endpoint:
bioaccumulation: aquatic / sediment
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
other: Applicant's summary entry
Rationale for reliability incl. deficiencies:
other: no reliability is given as this is an applicant's summary entry

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1992
Reference Type:
publication
Title:
Bioconcentration of Chlorobenzenes from Water by Rainbow Trout: Correlations with Partition Coefficients and Environmentral Residues
Author:
Oliver and Niimi
Year:
1983
Bibliographic source:
Environ. Sci. Technol., Vol. 17, No. 5, 287-291
Reference Type:
publication
Title:
Bioconcentration factors and kinetics of chlorobenzenes in a Juvenile Crab (Portunus pelagicus)
Author:
Mortimer M
Year:
1993
Bibliographic source:
Aust. J. Mar. Freshwater Res., 44,565-76
Reference Type:
publication
Title:
Partition Coefficients of organic compounds in lipid-water systems and correlations with fish bioconcentration factors
Author:
Chiou CT
Year:
1995
Bibliographic source:
Environ. Sci. Technol., Vol. 19, No. 1, pp. 57-62
Reference Type:
publication
Title:
Toxicokinetics of chlorobenzenes in fish
Author:
van Hoogen G, Opperhuizen A
Year:
1988
Bibliographic source:
Environ. Toxicol. Chem. 7(3), pp.213-219
Reference Type:
secondary source
Title:
Comparison of BCF models based on log P
Author:
Devillers J
Year:
1996
Bibliographic source:
Chemosphere, Vol. 33, No. 6 pp. 1047-1065
Reference Type:
publication
Title:
Biotransformation and toxicokinetics of trichloroanilines in fish in relation to their hydrophobicity
Author:
de Wolf et al.
Year:
1993
Bibliographic source:
Arch. Environ. Contam.Toxicol. 25, 110-117
Reference Type:
publication
Title:
Relationship between bioavailability and hydrophobicity: reduction of the uptake of organic chemicals by fish due to the sorption on particles
Author:
Schrap SM and Opperhuizen A
Year:
1990
Bibliographic source:
Environ. Toxicol. Chem. 9, 715-724

Materials and methods

Principles of method if other than guideline:
Applicant's summary entry
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

applicant's summary entry:

The log Kow is >3 indicating that bioconcentration in aquatic organisms may occur. In a number of bioaccumulation studies, the bioconcentration factor values (BCF) observed in fish ranged from 130 (MITI, 1992) to 2600 (Oliver and Niimi, 1983) to 12484 (Mortimer M,1993)

Oliver and Niiml (1983)

The rainbow trout exposed for 119 days in a flow through system at 4.3 ng/l showed a bioconcentration factor of 1200 while exposed to water containing 72 ng/l for 105 days showed a BCF of 2600 (Oliver and Niimi, 1983). The concentration level (ng/l) was chosen as this concentration was observed in water and effluents of the Great Lakes in.

(The BCF at the high- exposure level averaged 2.2 times higher than that at the low-exposure levels for all chemicals.)

 

 

Mortimer M (1993)

The uptake- and depuration-rate constants (k1, k2), according to first-order kinetics, were measured for a series of chlorobenzenes with juvenile crabs. The bioconcentration factor KB (KB in wet weight units) obtained from these rate constants.

1,2,3-trichlorobenzene: D (Calculated on a lipid basis BL)

Bioconcentration factor D : log KBL = 4.10 (KBL = 12484)  

Uptake-rate-constant D: k1 = 1910 1/h

Depuration-rate-constant : k2 = 0.153 1/h

 

 

Chiou CT (1985)

The Triolein-water partition coefficients (Ktw) have been determined. A comparison of log Ktw values with corresponding log (BFC) values reported by Könemann and van Leeuween with guppies (log BFC = 4.11; BFC =12882), and by Oliver and Nimi with rainbow trout (log BFC = 4.15 - 4.47 (BFC =14125 - 29512), expressed in the basis of the fish lipid content. Results show a close agreement between Ktw und BCF values for the compounds studied.

 

van Hoogen G, Opperhuizen A (1988)

Uptake and elimination rate constants measured in the bioconcentration experiments. Uptake rate constants were estimated from the increase in the concentration in fish after initial exposure, and elimination rate constants were calculated from the decreasing concentration in fish after they were transferred to clean water. Bioconcentration factors were calculated as the ratio between the uptake and elimination rate constants ( Kc = K1/k2).

K1 [ml/g d] = 780 +/- 220                             t 90% [d] a = 5.4

K2 [1/d] = 0.42 +/-0.06                                c f (4d) [%] b = 81

Kc [ml/g] = 1900

a         Time at which 90% of the theoretical steady- state concentration in fish is reached.

b         Concentration on fish after 4 d of accumulation, express as percentage of the theoretical steady-state concentration.

Devillers J. (1996) reported:

All values calculated on lipid content basis.

 

de Wolf et al. 1983: log BFC = 2.90 Poecilia reticluata (BFC=794)
Oliver , Niimi 1983: log BFC =3.08 Oncorhynchus mykiss (BFC=1202)
Schrap and Opperhuizen 1990: log BFC = 3.28 Poecilia reticluata (BFC=1905)
Oliver , Niimi 1983: log BFC =3.26 Oncorhynchus mykiss (BFC=1819)


Applicant's summary and conclusion