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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Title:
No information
Author:
Ariyoshi T. et al. (1975). Relationship beween chemical structure and activity. II. Influence of isomers in dichlorobenzene, trichlorobenzene and tetrachlorobenzene on the activities of drug-metabolizing enzymes. Chem. Pharm. Bull.23, 824-830

Materials and methods

Objective of study:
toxicokinetics
Principles of method if other than guideline:
Migrated dataset. Method: other: see freetext
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: other TS: 1,2,3-trichlorobenzene, no data on purity

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: traganth gum solution
Duration and frequency of treatment / exposure:
3 day(s)
Doses / concentrations
Remarks:
Doses / Concentrations:
Females: 0 or 250 mg/kg bw in 2% traganth gum solution
No. of animals per sex per dose:
Females: 6

Results and discussion

Any other information on results incl. tables

RS-Freetext:
body weight development and liver weights were affected by treatment.
The only parameters which were significant different from controls were  (mean values of 6 rats):
Microsomal protein content: 
18.3 mg/g liver versus 16.9 mg/g liver in control rats
Microsomal phosphorus content:
299 µg/g liver versus 238 µg/g liver in control rats
Cytochromes P-450:
0.84 nmoles/mg protein versus 0.70 nmoles/mg protein in control rats

Applicant's summary and conclusion