Registration Dossier
Registration Dossier
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EC number: 201-757-1 | CAS number: 87-61-6
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Documentation insufficient for assessment: there is no information on the ratio between polychromatic and normochromatic erythtocytes, in the publication the results of several chloroaromatic compounds are reported and report of the individual chemical is insufficient of assessment
Data source
Reference
- Title:
- No information
- Author:
- Mohtashamipur E. et al (1987). The bone marrow clastogenicity of eight halogenated benzenes in male NMRI mice. Mutagenesis
Materials and methods
- Principles of method if other than guideline:
- Method: other: bone marrow micronucleus test
- GLP compliance:
- not specified
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- 1,2,3-trichlorobenzene
- EC Number:
- 201-757-1
- EC Name:
- 1,2,3-trichlorobenzene
- Cas Number:
- 87-61-6
- Molecular formula:
- C6H3Cl3
- IUPAC Name:
- 1,2,3-trichlorobenzene
- Details on test material:
- IUCLID4 Test substance: other TS: 1,2,3-trichlorobenzene, purity: 99%
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Duration of treatment / exposure:
- 2 injections in a 24 h intervall
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2 x 125, 250, 375, 500 mg/kg bw dissolved in corn oil
Basis:
- No. of animals per sex per dose:
- Migrated dataset
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- positive
Any other information on results incl. tables
RS-Freetext:
positive: the number of micronucleated polychromatic erythrocytes was dose-dependently increased starting at the lowest dose when compared to the concurrent vehicle control.
Applicant's summary and conclusion
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