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Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Documentation insufficient for assessment: there is no information on the ratio between polychromatic and normochromatic erythtocytes, in the publication the results of several chloroaromatic compounds are reported and report of the individual chemical is insufficient of assessment

Data source

Reference
Title:
No information
Author:
Mohtashamipur E. et al (1987). The bone marrow clastogenicity of eight halogenated benzenes in male NMRI mice. Mutagenesis

Materials and methods

Principles of method if other than guideline:
Migrated dataset. Method: other: bone marrow micronucleus test
GLP compliance:
not specified
Type of assay:
micronucleus assay

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: other TS: 1,2,3-trichlorobenzene, purity: 99%

Test animals

Species:
mouse
Strain:
NMRI
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Duration of treatment / exposure:
2 injections in a 24 h intervall
Doses / concentrations
Remarks:
Doses / Concentrations:
2 x 125, 250, 375, 500 mg/kg bw dissolved in corn oil
Basis:

No. of animals per sex per dose:
Migrated dataset

Examinations

Tissues and cell types examined:
Migrated dataset

Results and discussion

Test results
Sex:
male
Genotoxicity:
positive

Any other information on results incl. tables

Migrated dataset. RS-Freetext:
positive: the number of micronucleated polychromatic erythrocytes was  dose-dependently increased starting at the lowest dose when compared to  the concurrent vehicle control.

Applicant's summary and conclusion