Registered substances
Registered substances
In this table, you will find all public data submitted to ECHA in REACH registration dossiers by substance manufacturers, importers, or their representatives, as laid out by the REACH Regulation (see Understanding REACH regulation).
ECHA makes available this information as REACH registered substance factsheets, which contain the full set of non-confidential information from related registration dossiers for a substance. Depending on the number of registrations that have been made for a substance, one factsheet can thus represent data from anything between hundreds of registration dossiers in a joint submission, to data from just one registration dossier.
As noted in the Legal Notice of the ECHA website, ECHA does not give any guarantees or warranties regarding the quality and correctness of the published information. The information in the portal is published ‘as provided’ by industry, and its accuracy has not been verified by ECHA. ECHA is also not in a position to intervene with, edit or correct the published data; this can only be done by the registrant responsible for its submission. Please also note that the information may be protected and its use may require prior permission from its owner (see the ECHA website Legal Notice more details).
In the portal results table are presented:
- Public substance identity – the best available non-confidential substance name, EC, and CAS numbers.
- Registration status – indicating the calculated registration status: Active - being actively manufactured or imported to the EEA; Cease manufacture - is no longer being manufactured or imported, but still considered to have a valid registration under REACH, and capable of resuming manufacture or import at any time; or No longer valid - no longer considered registered under REACH and not currently permitted to be manufactured or imported to the EEA unless and until properly registered again.
- Registration type – indicating whether a given factsheet contains data from a REACH full registration, REACH intermediate registration, or only a limited set of data inherited from a NONS notification.
- Submission type – indicating whether the data in a given factsheet was submitted jointly or individually.
- Total tonnage band – calculated per factsheet from all contributing registrations, based on the estimated quantity of the substance placed on the market. Data is excluded from dossiers where the tonnage is claimed confidential, from Intermediate registration dossiers, and from NONs which have not been updated.
- Last updated – indicating the date on which this registered substance factsheet was last modified with new or updated data, based on an industry submission.
- Link to the full factsheet.
A subset of the key chemical properties (physico-chemical, environmental fate, ecotoxicological and toxicological data) of registered substances can be searched and accessed via the OECD eChemPortal.
Please note:
- The REACH Registered substance portal was updated on 9th November 2020; the REACH registered factsheets were further updated on 21st December 2020. Details of the improvements can be found at Dissemination Platform Updates. Reprocessing the entire dataset is ongoing since 21 December 2020. ECHA is making all possible efforts to make the improvements and additional data visible with the shortest delay.
- The ‘Substance has nanoform’ search filter returns all factsheets containing any data related to nanomaterials. NB: This does not mean that a registration covering nanoforms has been submitted in line with the revised annexes of REACH. Since 1 January 2020, before manufacturing or importing a nanoform of a substance, the operators concerned must submit the required nano-specific information to ECHA in a new or updated registration dossier.
Further information
- Registered substances information
- How to determine what will be published (Data Submission Manual 15)
- Understanding REACH Regulation
- Q&A on registered substances
- What is an Infocard? [PDF]
- What is a Registered substance Factsheet? [PDF]
- eChemPortal
- REACH study results download
- REACH Regulation
- ECHA Legal notice
Last updated 27 February 2021. Database contains 23117 unique substances and contains information from 96054 dossiers.
| Registrant/Supplier | Address | Country | Registration Status | Name | EC / List no. | CAS no. | Last update year | Details |
|---|---|---|---|---|---|---|---|---|
| DSM Nutritional Products France SAS | 1 boulevard d'Alsace F-68128 Village-Neuf France | France | Active | (E,E)-3,7,11-trimethyldodeca-1,4,6,10-tetraen-3-ol | 423-240-1 | 125474-34-2 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (E,Z)-4-chlorophenyl(cyclopropyl)ketone O-(4-nitrophenylmethyl)oxime | 406-100-4 | 94097-88-8 | - | View substance registered dossier |
| NOVEAL | 16 rue Maurice Berteaux 95500 LE THILLAY France | France | Active | (E-E )-3,3'-(1,4-phenylenedimethylidene)bis(2-oxobornane-10-sulfonic acid) | 410-960-6 | 92761-26-7 | 2011; 2020 | View substance registered dossier |
| PCAS | 21 Chemin de la Sauvegarde 21 Ecully Parc - CS33167 69134 ECULLY France | France | Active | (E-E )-3,3'-(1,4-phenylenedimethylidene)bis(2-oxobornane-10-sulfonic acid) | 410-960-6 | 92761-26-7 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (ethyl-1,2-ethanediyl)]-2-[[[(2-hydroxyethyl)methylamino]acetyl]propyl]ω-(nonylphenoxy)poly[oxy(methyl-1,2-ethanediyl) | 418-960-8 | - | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (ethyl-3-oxobutanoato-O'1,O'3)(2-dimethylaminoethanolato)(1-methoxypropan-2-olato)aluminium(III), dimerised | 402-370-2 | 149057-70-5 | - | View substance registered dossier |
| - | - | - | - | (imidazol-5-yl)ethyl-3-aminopropionamide dihydrochloride | 415-470-6 | - | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant French competent national authority. | - | - | Active | (methylenebis(4,1-phenylenazo(1-(3-(dimethylamino)propyl)-1,2-dihydro-6-hydroxy-4-methyl-2-oxopyridine-5,3-diyl)))-1,1'-dipyridinium dichloride dihydrochloride | 401-500-5 | 118658-99-4 | - | View substance registered dossier |
| ARCHROMA IBÉRICA, S.L. | ZAL-Prat c/Cal Coracero, 46-56 08820 El Prat de Llobregat Spain | Spain | Active | (methylenebis(4,1-phenylenazo(1-(3-(dimethylamino)propyl)-1,2-dihydro-6-hydroxy-4-methyl-2-oxopyridine-5,3-diyl)))-1,1'-dipyridinium dichloride dihydrochloride | 401-500-5 | 118658-99-4 | - | View substance registered dossier |
| Archroma Germany GmbH | Kasteler Str. 45 65203 Wiesbaden Germany | Germany | Active | (methylenebis(4,1-phenylenazo(1-(3-(dimethylamino)propyl)-1,2-dihydro-6-hydroxy-4-methyl-2-oxopyridine-5,3-diyl)))-1,1'-dipyridinium dichloride dihydrochloride | 401-500-5 | 118658-99-4 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant Spanish competent national authority. | - | - | Active | (methylenebis(4,1-phenylenazo(1-(3-(dimethylamino)propyl)-1,2-dihydro-6-hydroxy-4-methyl-2-oxopyridine-5,3-diyl)))-1,1'-dipyridinium dichloride dihydrochloride | 401-500-5 | 118658-99-4 | - | View substance registered dossier |
| Archroma UK, Ltd | 1 Bartholomew Lane EC2N 2AX London United Kingdom | United Kingdom | Active | (methylenebis(4,1-phenylenazo(1-(3-(dimethylamino)propyl)-1,2-dihydro-6-hydroxy-4-methyl-2-oxopyridine-5,3-diyl)))-1,1'-dipyridinium dichloride dihydrochloride | 401-500-5 | 118658-99-4 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant Dutch competent national authority. | - | - | Active | (methylenebis(4,1-phenylenazo(1-(3-(dimethylamino)propyl)-1,2-dihydro-6-hydroxy-4-methyl-2-oxopyridine-5,3-diyl)))-1,1'-dipyridinium dichloride dihydrochloride | 401-500-5 | 118658-99-4 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. | - | - | Active | (N-benzyl-N,N,N-tributyl)ammonium 4-dodecylbenzenesulfonate | 422-200-0 | 178277-55-9 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. | - | - | Active | (R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-veratrylisoquinoline hydrochloride | 415-110-8 | 54417-53-7 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-veratrylisoquinoline hydrochloride | 415-110-8 | 54417-53-7 | - | View substance registered dossier |
| Covance Clinical Development SA 169 | Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain | Spain | Active | (R)-1-chloro-2,3-epoxypropane | 424-280-2 | 51594-55-9 | 2011 | View substance registered dossier |
| COVANCE CLINICAL DEVELOPMENT SA 171 | Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain | Spain | Active | (R)-1-chloro-2,3-epoxypropane | 424-280-2 | 51594-55-9 | - | View substance registered dossier |
| Deretil S.A. | Villaricos, s/n 04618 Cuevas del Almanzora Almeria Spain | Spain | Cease Manufacture | (R)-1-cyclohexa-1,4-dienyl-1-methoxycarbonyl-methylammoniumchloride | 444-320-2 | - | 2019 | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. | - | - | Active | (R)-1-cyclohexa-1,4-dienyl-1-methoxycarbonyl-methylammoniumchloride | 444-320-2 | - | - | View substance registered dossier |
| RHODIA OPERATIONS | 52 rue de la Haie Coq 93300 AUBERVILLIERS France | France | Active | (R)-2-(4-hydroxyphenoxy)propanoic acid | 407-960-3 | 94050-90-5 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant Belgian competent national authority. | - | - | Active | (R)-2-(4-hydroxyphenoxy)propanoic acid | 407-960-3 | 94050-90-5 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (R)-2-acetamido-3-naphthyl-2-yl-propionic acid | 440-450-9 | - | - | View substance registered dossier |
| - | - | - | - | (R)-2-bromo-3-methylbutyric acid diisopropylamine salt | 448-650-8 | 169320-29-0 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (R)-2-tert-butoxycarbonylamino-3-(4-chlorophenyl)propionic acid | 438-070-3 | - | - | View substance registered dossier |
| - | - | - | - | (R)-2-tert-butoxycarbonylamino-3-(pyridin-3-yl)propionic acid | 441-200-1 | - | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (R)-3-[(1-methylpyrrolidin-2-yl)methyl]-5-[2-(phenylsulfonyl)ethenyl]-1H-indole | 430-560-5 | 180637-89-2 | - | View substance registered dossier |
| COVANCE CLINICAL DEVELOPMENT SA 171 | Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain | Spain | Cease Manufacture | (R)-3-chloropropane-1,2-diol | 435-560-9 | 57090-45-6 | 2012 | View substance registered dossier |
| - | - | - | - | (R)-3-Methylhexanoic acid | 471-550-0 | 22328-90-1 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. | - | - | Active | (R)-3-Methylhexanoic acid | 471-550-0 | 22328-90-1 | - | View substance registered dossier |
| Pfizer Ireland Pharmaceuticals | n/a P43 X3336 Ringaskiddy Cork Ireland | Ireland | Active | (R)-3-Methylhexanoic acid | 471-550-0 | 22328-90-1 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (R)-4-(4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile | 430-760-2 | 219861-18-4 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant Irish competent national authority. | - | - | Active | (R)-4-(4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile | 430-760-2 | 219861-18-4 | - | View substance registered dossier |
| - | - | - | - | (R)-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide | 419-800-1 | - | - | View substance registered dossier |
| Pfizer Ireland Pharmaceuticals | n/a P43 X3336 Ringaskiddy Cork Ireland | Ireland | No longer Valid | (R)-5-bromo-3-(1-methyl-2-pyrrolidinyl methyl)-1H-indole | 422-390-5 | 143322-57-0 | 2013 | View substance registered dossier |
| ORGAPHARM | Rue du Moulin de la Canne 45300 PITHIVIERS France | France | Active | (R)-5-bromo-3-(1-methyl-2-pyrrolidinyl methyl)-1H-indole | 422-390-5 | 143322-57-0 | - | View substance registered dossier |
| - | - | - | - | (R)-α-phenylethylammonium (-)-(1R, 2S)-(1,2-epoxypropyl)phosphonate monohydrate | 418-570-8 | 25383-07-7 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant French competent national authority. | - | - | Active | (R,S)-1-[2-amino-1(4-methoxyphenyl)ethyl]cyclohexanol acetate | 445-750-3 | 839705-03-2 | - | View substance registered dossier |
| Zach System | ZI La Croix Cadeau 49242 Avrillé France | France | Active | (R,S)-1-[2-amino-1(4-methoxyphenyl)ethyl]cyclohexanol acetate | 445-750-3 | 839705-03-2 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant Dutch competent national authority. | - | - | Active | (R,S)-2-amino-3,3-dimethylbutane amide | 447-860-7 | 144177-62-8 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant Belgian competent national authority. | - | - | Active | (R,S)-2-azabicyclo[2.2.1]hept-5-en-3-one | 421-830-3 | 49805-30-3 | - | View substance registered dossier |
| Lonza Cologne GmbH - REACH | Nattermannallee 1 50829 Cologne Germany | Germany | Active | (R,S)-2-azabicyclo[2.2.1]hept-5-en-3-one | 421-830-3 | 49805-30-3 | 2010 | View substance registered dossier |
| Mitsui & Co. Europe PLC London Branch | 1 St Martin's Le Grand EC1A 4AS London United Kingdom | United Kingdom | Active | (R,S)-2-azabicyclo[2.2.1]hept-5-en-3-one | 421-830-3 | 49805-30-3 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (R,S)-2-azabicyclo[2.2.1]hept-5-en-3-one | 421-830-3 | 49805-30-3 | - | View substance registered dossier |
| Vishay BCcomponents B.V. | Ceintuurbaan 15 8022 AW Zwolle Netherlands | Netherlands | Active | (R,S)-2-butyloctanedioic acid | 431-210-4 | 50905-10-7 | - | View substance registered dossier |
| Syngenta Ltd | Jealott’s Hill International Research Centre RG42 6EY Bracknell Berkshire United Kingdom | United Kingdom | Cease Manufacture | (RS)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)hexan-2-ol | 413-050-7 | 79983-71-4 | 2013 | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant Belgian competent national authority. | - | - | Active | (RS)-3-dichloroacetyl-5-(2-furanyl)-2,2-dimethyloxazolidine | 434-800-1 | - | - | View substance registered dossier |
| - | - | - | - | (S) 4-hydroxy-3-methyl-2-prop-2-ynylcyclopent-2-en-1-one | 462-540-7 | 77087-34-4 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (S)-(+)-3-Hydroxytetrahydrofuran | 425-090-2 | - | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (S)-(-)-tetrahydro-2-furoic acid | 433-770-5 | - | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant Danish competent national authority. | - | - | Active | (S)-.alpha.-cyano-3-phenoxybenzyl (Z)-(1R)-cis-3-(2-chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropanecarboxylate | 435-840-0 | 76703-62-3 | - | View substance registered dossier |
| DSM Nutritional Products GmbH | Emil-Barell-Str. 3 79639 Grenzach-Wyhlen Germany | Germany | Cease Manufacture | (S)-1,1-diphenyl-1,2-propanediol | 443-220-6 | 46755-94-6 | 2019 | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (S)-1,2,4-butanetriyltrimethanesulfonate | 433-850-1 | - | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant French competent national authority. | - | - | Active | (S)-1-[2-tert-butoxycarbonyl-3-(2-methoxyethoxy)propyl]-1-cyclopentanecarboxylic acid, cyclohexylamine salt | 425-510-4 | 167944-94-7 | - | View substance registered dossier |
| DSM Pharma Chemicals Venlo B.V. | Grubbenvorsterweg 8 Postbox 81 5900 AB Venlo Netherlands | Netherlands | Active | (S)-2,3-dihydro-1H-indole-2-carboxylic acid | 410-860-2 | 79815-20-6 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. | - | - | Active | (S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1-trityl-1H-imidazol-4-yl)propionic acid | 439-640-4 | - | - | View substance registered dossier |
| Roche Pharma AG (1) | Emil-Barell-Strasse 1 79639 Grenzach-Wyhlen Germany | Germany | Cease Manufacture | (S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1-trityl-1H-imidazol-4-yl)propionic acid | 439-640-4 | - | 2019 | View substance registered dossier |
| - | - | - | - | (S)-2-chloropropionic acid | 411-150-5 | 29617-66-1 | - | View substance registered dossier |
| [Confidential] | - | - | - | (S)-2-methyl-3,4,5,6-tetrahydropyrimidine-4-carboxylic acid | 431-910-1 | - | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. | - | - | Active | (S)-2-methyl-3,4,5,6-tetrahydropyrimidine-4-carboxylic acid | 431-910-1 | - | - | View substance registered dossier |
| Pfizer Ireland Pharmaceuticals | n/a P43 X3336 Ringaskiddy Cork Ireland | Ireland | Active | (S)-3-benzyloxycarbonyl-1,2,3,4-tetrahydro-isoquinolinium 4-methylbenzenesulfonate | 406-960-0 | 77497-97-3 | - | View substance registered dossier |
| Fine Organics Limited | Seal Sands TS2 1UB Middlesbrough Teesside United Kingdom | United Kingdom | Active | (S)-3-benzyloxycarbonyl-1,2,3,4-tetrahydro-isoquinolinium 4-methylbenzenesulfonate | 406-960-0 | 77497-97-3 | - | View substance registered dossier |
| MAPIC Europe NV | EXCELSIORLAAN 83 1930 ZAVENTEM Belgium | Belgium | Cease Manufacture | (S)-3-benzyloxycarbonyl-1,2,3,4-tetrahydro-isoquinolinium 4-methylbenzenesulfonate | 406-960-0 | 77497-97-3 | 2019 | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant German competent national authority. | - | - | Active | (S)-3-benzyloxycarbonyl-1,2,3,4-tetrahydro-isoquinolinium 4-methylbenzenesulfonate | 406-960-0 | 77497-97-3 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (S)-3-benzyloxycarbonyl-1,2,3,4-tetrahydro-isoquinolinium 4-methylbenzenesulfonate | 406-960-0 | 77497-97-3 | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant UK competent national authority. | - | - | Active | (S)-3-hydroxy-γ-butyrolactone | 434-990-4 | 7331-52-4 | - | View substance registered dossier |
| Amri Italy S.r.l. | VIA DEL VECCHIO POLITECNICO, n. 9 20121 Milano Italy | Italy | Active | (S)-3-methyl-2-(2-oxotetrahydropyrimidine-1-yl)butyric acid | 430-900-2 | 192725-50-1 | - | View substance registered dossier |
| H. Lundbeck A/S | Ottiliavej 7-9 2500 Copenhagen Denmark | - | - | (S)-4-(4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile | 430-770-7 | 128173-52-4 | - | View substance registered dossier |
| - | - | - | - | (S)-4-amino-5-[(2-(1H-imidazol-4-yl)ethyl)amino]-5-oxopentanoic acid | 421-900-3 | - | - | View substance registered dossier |
| Former NONS notifier unknown to ECHA - Contact the relevant Spanish competent national authority. | - | - | Active | (S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione | 444-280-6 | 7689-03-4 | - | View substance registered dossier |
| bracco imaging | Via Folli 50 20134 milan Italy | Italy | Active | (S)-5-[2-(acetyloxy)propanamido]-2,4,6-triiodo-1,3-di(chloroformyl)benzene | 410-940-7 | - | - | View substance registered dossier |
| - | - | - | - | (S)-[2-(phenylmethoxy)propylidene]hydrazinecarboxylate, tert-butyle | 439-220-0 | - | - | View substance registered dossier |
| AstraZeneca | B313:5 AZ GlobalSHE- Chem.Reg. SE-15185 Södertälje Sweden | Sweden | Cease Manufacture | (S)-azetidine-2-carboxylic acid 4-cyanobenzylamide hydrochloride | 433-010-2 | - | 2012 | View substance registered dossier |
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