Registration Dossier
Registration Dossier
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EC number: 231-743-0 | CAS number: 7718-54-9
Endpoint summary
Administrative data
Description of key information
Value used for CSA:
Skin irritation / corrosion: irritating
Eye irritation: not irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
There is some human data for skin irritancy of nickel chloride, but no skin or eye irritation data from animal studies on nickel chloride have been found. Human data for nickel chloride shows skin irritation, and classification is considered relevant. Skin irritation is also seen with nickel sulphate in similar studies.Nickel chloride is classified as Skin Irrit. 2: H315 in the 1st ATP to the CLP Regulation with a specific concentration limit of 20%.
Data on eye irritation is available for nickel sulphate. There is no reason to believe that the eye irritating potential of nickel chloride will exceed that of nickel sulphate. Nickel chloride is not classified for eye irritation under CLP.
Regarding respiratory irritation the available data on nickel chloride do not allow a conclusion for this endpoint.
The following information is taken into account for any hazard / risk assessment:
There are some human data for skin irritancy of nickel chloride, but no skin or eye irritation data from animalstudies on nickel chloride have been found. Human data for nickel chloride shows skin irritation, and classification is considered relevant. This is supported by data using read-across from nickel sulphate to set the concentration limit since nickel sulphate has been shown to be irritating to skin in humans at concentrations greater than 20%. A comprehensive summary on this topic is provided in Appendix B3.
Data regarding eye irritation of Ni acetate are read-across from Ni sulphate. Ni sulphate has been demonstrated not to be an eye irritant in experimental animals.
The available data do not allow any conclusion on respiratory irritation.
Value used for CSA:
Skin irritation / corrosion: irritating
Eye irritation: not irritating
Justification for classification or non-classification
Ni chloride is classified as Skin Irrit. 2: H315 in the 1st ATP to the CLP Regulation with a specific concentration limit of 20%. Ni chloride is not classified for eye irritation based on experimental data in animals with Ni sulphate.A comprehensive summary on this topic is provided in Appendix B3.
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