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EC number: 231-743-0
CAS number: 7718-54-9
of 100 mg/kg bw (or ~20 mg Ni/kg bw/day)
SUMMARY DEVELOPED BY AN INDEPENDENT REVIEWER.
The acute toxicity of the test substance was determined by oral administration to male and female Sprague Dawley rats. Test animals were
obtained from Charles River Breeding Laboratories, Inc., Wilmington, MA, USA. Animals were individually housed, provided food and water ad
libitum, and acclimatized for at least 5 days prior to testing. The test substance was dissolved in water.
Two studies were conducted, an initial dose range-finding study and a subsequent main study. Animals were fasted overnight prior to initiation
of the main study. The dose levels chosen for the main study, based on the results of the range-finding study, were 50, 98, 194, 381, and 750
mg/kg. Groups of 10 animals (5 males and 5 females) received a single oral dose of one of the test substance concentrations.
Animals were observed frequently for signs of toxicity or mortality and body weights were measured on days 0 (i.e., test initiation), 8, and 15,
or at death. Fasted body weights ranged from 352.4-375.6 g for males and 239.2-254.8 g for females. Surviving animals were sacrificed on day 15,
and all animals were necropsied and examined for abnormalities. Acute oral toxicity values (w/ 95% confidence limits) were calculated from the
mortality data using the method of Miller and Tainter (1944). Dose-mortality curves were plotted (normal log graph).
Cumulative mortality observed (number of mortalities observed/total number of animals tested), by nominal dose administered:
50 mg/kg: 0/5 males; 0/5 females
98 mg/kg: 0/5 males; 0/5 females
194 mg/kg: 3/5 males; 4/5 females (deaths occurred by day 2)
381 mg/kg: 4/5 males; 5/5 females (deaths occurred on day 1)
750 mg/kg: 5/5 males; 5/5 females (deaths occurred on day 1)
Symptoms observed in more than one animal/dose group were decreased activity (98, 194, and 381 mg/kg groups), salivation (98 and 194 mg/kg
groups), and ataxia and swollen limbs (194 mg/kg group). Mean body weights of surviving rats increased during the 15-day study period.
Necropsy findings were negative for all dose groups.
Acute oral toxicity (LD50) values (95% confidence limits), by sex tested:
LD50 (males): 210 (159-261) mg/kg bw
LD50 (females): 175 (131-219) mg/kg bw
LD50 (both sexes): 200 (186-214) mg/kg bw
RATED BY AN INDEPENDENT REVIEWER.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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