Nickel dichloride

GHS

General Information

Name:

Nickel dichloride

Implementation:

EU

Remarks:

• Acute oral toxicity. Ni chloride is currently classified for acute oral toxicity as Acute Tox. 3;H301 according to the 1st ATP to the CLP Regulation. A newly conducted GLP OECD guideline compliant study reported an LD50 =500 mg/kg for Ni chloride hexahydrate, suggesting the classification could be downgraded to Acute Tox. 4; H302. An Acute Tox 4 classification for nickel chloride would be consistent with the acute oral toxicity classification for all other water soluble nickel compounds. However, an older study already exists in which the results correspond to the current harmonized classification, thus the harmonized classification continues to be reflected in this file.
  
• Acute inhalation toxicity. Ni chloride is currently classified as Acute Tox. 3:H331 according to the 1st ATP to the CLP Regulation. This is further supported by the outcome of the in vivo acute oral toxicity studies completed by PSL in 2015, reporting an LC50 of 0.5934 mg/L air for male rats and 0.7464 mg/L air for female rats. Therefore, no change to the existing classification is proposed within this registration file. A complete summary of the study including results and discussion are provided in Section 7.2.2 of IUCLID and Section 5.2 of this CSR.
  

Classification

Physical hazards

Explosives

Reason for no classification:

data conclusive but not sufficient for classification

Flammable gases and chemically unstable gases

Reason for no classification:

data conclusive but not sufficient for classification

Aerosols

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

hazard class not assessed

Oxidising gases

Reason for no classification:

data conclusive but not sufficient for classification

Gases under pressure

Reason for no classification:

data conclusive but not sufficient for classification

Flammable liquids

Reason for no classification:

data conclusive but not sufficient for classification

Flammable solids

Reason for no classification:

data conclusive but not sufficient for classification

Self-reactive substances and mixtures

Reason for no classification:

data conclusive but not sufficient for classification

Pyrophoric liquids

Reason for no classification:

data conclusive but not sufficient for classification

Pyrophoric solids

Reason for no classification:

data conclusive but not sufficient for classification

Self-heating substances and mixtures

Reason for no classification:

data conclusive but not sufficient for classification

Substances and mixtures which in contact with water emit flammable gases

Reason for no classification:

data conclusive but not sufficient for classification

Oxidising liquids

Reason for no classification:

data conclusive but not sufficient for classification

Oxidising solids

Reason for no classification:

data conclusive but not sufficient for classification

Organic peroxides

Reason for no classification:

data conclusive but not sufficient for classification

Corrosive to metals

Reason for no classification:

data lacking

Desensitized explosives

Reason for no classification:

data lacking

Health hazards

Acute toxicity - oral

Hazard category:

Acute Tox. 3

Hazard statement:

H301: Toxic if swallowed.

Acute toxicity - dermal

Reason for no classification:

data conclusive but not sufficient for classification

Acute toxicity - inhalation

Hazard category:

Acute Tox. 3

Hazard statement:

H331: Toxic if inhaled.

Skin corrosion / irritation

Hazard category:

Skin Irrit. 2

Hazard statement:

H315: Causes skin irritation.

Serious eye damage / eye irritation

Reason for no classification:

data conclusive but not sufficient for classification

Respiratory sensitisation

Hazard category:

Resp. Sens. 1

Hazard statement:

H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled.

Skin sensitisation

Hazard category:

Skin Sens. 1

Hazard statement:

H317: May cause an allergic skin reaction.

Aspiration hazard

Reason for no classification:

data lacking

Reproductive toxicity

Hazard category:

Repr. 1B

Hazard statement:

H360: May damage fertility or the unborn child <state specific effect if known > <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

Specific effect:

Perinatal mortality

Effects on or via lactation

Reason for no classification:

data conclusive but not sufficient for classification

Germ cell mutagenicity

Hazard category:

Muta. 2

Hazard statement:

H341: Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

Carcinogenicity

Hazard category:

Carc. 1A

Hazard statement:

H350: May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

Route of exposure:

inhalation

1. Specific target organ toxicity - single (STOT-SE)

Reason for no classification:

data conclusive but not sufficient for classification

1. Specific target organ toxicity - repeated (STOT-RE)

Hazard category:

STOT Rep. Exp. 1

Hazard statement:

H372: Causes damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

Affected organs:

lungs

Route of exposure:

inhalation

Specific concetration limits

1.

Concentration range (%):

>= 20

Hazard categories:

Skin Irrit. 2

2.

Concentration range (%):

>= 0.01

Hazard categories:

Skin Sens. 1

3.

Concentration range (%):

>= 1

Hazard categories:

STOT Rep. Exp. 1

4.

Concentration range (%):

>= 0.1 - < 1

Hazard categories:

STOT Rep. Exp. 2

Environmental hazards

Hazardous to the aquatic environment (acute / short-term)

Hazard category:

Aquatic Acute 1

Hazard statement:

H400: Very toxic to aquatic life.

Hazardous to the aquatic environment (long-term)

Hazard category:

Aquatic Chronic 1

Hazard statement:

H410: Very toxic to aquatic life with long lasting effects.

M-Factor acute:

1

M-Factor chronic:

1

Hazardous to the ozone layer

Reason for no classification:

data conclusive but not sufficient for classification

Labelling

Signal word:

Danger

Hazard pictogram

GHS06: skull and crossbones

GHS08: health hazard

GHS09: environment

Hazard statements

H350: May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

by Inhalation Only

H341: Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

H360: May damage fertility or the unborn child <state specific effect if known > <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

Perinatal mortality

H331: Toxic if inhaled.

H301: Toxic if swallowed.

H372: Causes damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

by Inhalation Only

H315: Causes skin irritation.

H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled.

H317: May cause an allergic skin reaction.

H410: Very toxic to aquatic life with long lasting effects.