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Short-term toxicity to fish

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Key value for chemical safety assessment

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From the database of acute toxicity to freshwater fish, there are many high quality studies.  This represents different freshwater fish species, dominated by Pimephales promelas,Oncorhynchus mykiss, and Cyprinus carpio.  The 96h LC50s values range from 0.4 mg Ni/L (Pimephales promelas; Hoanget al., 2004) to 320 mg Ni/L (Brachydaniorerio; Janssen Pharmaceutica, 1993d).  


From the database of acute toxicity to marine fish, there are high quality studies representing different marine fish species.  The 96h LC50s values range from24.8 mg Ni/L (Fundulus heteroclitus; Bielmyeret al., 2013)to 350 mg Ni/L (Fundulus heteroclitus; Eisler and Hennekey, 1977).  

As the PNEC intermittent endpoint is not relevant for the identified processes, no short-term tests are used in any PNEC derivation.