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EC number: 231-743-0
CAS number: 7718-54-9
Ijomone et al (2018). Sub-acute nickel exposure impairs behavior, alters neuronal microarchitecture, and induces oxidative stress in rats’ brain. Drug and Chemical Toxicology; 41(4):377 -384.
This study investigated the behavior and histopathological alterations in the brains of rats exposed to 5, 10 or 20 mg/kg nickel chloride, through intraperitoneal injection for 21 days. Treatment with nickel significantly increased mortality at 20 mg/kg, as three deaths occurred in the third week of treatment.
K3: Does not meet important study design or analytical criteria. Irrelevant route of exposure - intraperitoneal injection.
Study rated by an independent reviewer
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