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EC number: 231-743-0
CAS number: 7718-54-9
SUMMARY DEVELOPED BY AN INDEPENDENT REVIEWER.
Robust Summary for Nation et al.
Adult male Sprague-Dawley rats were fed either 0, 10, or 20 mg Ni/kg body weight (as NiCl2) via a 10 g daily food ration. Following 14 days of
exposure, animals were trained over a period of 61 days to lever press for food on a VI-2 operant training schedule while continuing to
experience the indicated daily doses. Those rats treated with 20 mg/kg Ni lever pressed at a significantly lower rate than controls. Behavior of
the animals from the 10 mg/kg group was not significantly different than control subjects. Atomic absorption spectrophotometric analysis revealed
a dose/response accumulation of Ni in the kidney, but analyses of blood, bone, brain, hair, small intestine, liver, and testes did not show
differential agent accumulations. Neither hepatic nor renal metallothionein levels were increased above control levels.
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