EU-IMPLANTABLE_MEDICAL_DEVICES-ART_3_ANX_1

Active Implantable Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 90/385/EEC on Active Implantable Medical Devices, 20 July 1990, amended by Directive 2007/47/EC, 21 September 2007

This list contains hazardous substances for purposes of Directive 90/385/EEC on active implantable medical devices, particularly as regards Article 3 and Annex I (Essential Requirements). This non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list). Please note that Regulation (EU) 2017/745 on medical devices has repealed Directive 90/385/EEC and begun to apply from 26 May 2021. Nevertheless, Article 120 of the Regulation provides for a transitional period allowing medical devices, under specified conditions (e.g., placed on the market prior to 26 May 2021), to continue to comply with the Directive. In accordance with the fourth paragraph of Article 120, this period ends 26 May 2025.

Last updated 26 balandis 2024. Database contains 4753 unique substances/entries.

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Substance Name	EC No.	CAS No.	EU CLP (1272/2008)	EU_BA Directive 2000/54/EC	EU REACH: List of SVHC
methyl 2,2-dimethyl-6-methylenecyclohexanecarboxylate	432-350-9	81752-87-6	Skin Irrit. 2
methyl 2,5-dichlorobenzoate	220-815-7	2905-69-3	Acute Tox. 4; STOT SE 3
methyl 2-(2-nitrobenzylidene)acetoacetate 2-NITROBENZYLIDENE METHYL ESTER; BAY O 2787	400-650-9	39562-27-1	Skin Sens. 1
methyl 2-(3-nitrobenzylidene)acetoacetate BM	405-270-7	39562-17-9	Skin Sens. 1
methyl 2-(acetylamino)-3-chloropropionate	442-860-3	87333-22-0	Skin Sens. 1
methyl 2-[4-(2-chloro-4-nitrophenylazo)-3-(1-oxopropyl)amino]phenylaminopropionate DISPERSE RED CLA 282	416-240-8	155522-12-6	Skin Sens. 1
methyl 2-aminosulfonyl-6-(trifluoromethyl)pyridine-3-c arboxylate JE 127	421-220-7	144740-59-0	Skin Sens. 1
methyl 2-benzylidene-3-oxobutyrate LUGALVAN ES 9571	420-940-9	15768-07-7	Eye Irrit. 2; Skin Irrit. 2
methyl 2-chlorosulfonyl-4-(methanesulfonylaminomethyl) benzoate	443-120-2	393509-79-0	Eye Dam. 1
methyl 2R,3S-(-)-3-(4-methoxyphenyl)oxiranecarboxylate MEFAT	404-130-2	105560-93-8	Eye Dam. 1; Skin Sens. 1
methyl 3,4-dichlorophenylcarbanilate; SWEP.	620-362-9	1918-18-9	Acute Tox. 4
methyl 3-(3-tert-butyl-4-hydroxy-5-methylphenyl)propionate G 18-1108	403-270-1	6386-39-6	Acute Tox. 4
methyl 3-(acetylthio)-2-methyl-propanoate D,L-ESTER	411-040-7	97101-46-7	Acute Tox. 4; Skin Sens. 1
methyl 3-[(dimethoxyphosphinothioyl)oxy]methacrylate	250-366-2	30864-28-9	Acute Tox. 4; Skin Sens. 1
methyl 3-amino-2,2,3-trimethylbutyrate	431-720-7	90886-53-6	Skin Corr. 1B; Acute Tox. 4
methyl 3-amino-4,6-dibromo-2-methyl-benzoate	425-190-6	119916-05-1	STOT RE 2
methyl 3-isocyanatosulfonyl-2-thiophene-carboxylate F7641; MTSI	410-550-7	79277-18-2	STOT RE 2; Resp. Sens. 1; Skin Sens. 1
methyl 3-sulphamoyl-2-thenoate A5546	402-050-2	59337-93-8	Skin Sens. 1
methyl 4-bromomethyl-3-methoxybenzoate BROMBENZOAT; BROMOBENZOATE	410-310-1	70264-94-7	Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
methyl [2-(1,1-dimethylethyl)-6-methoxypyrimidin-4-yl]ethylphosphonothioate MAT 9460	414-080-3	117291-73-3	Acute Tox. 4
methyl acetate	201-185-2	79-20-9	Flam. Liq. 2; Eye Irrit. 2; STOT SE 3
methyl acetoacetate	203-299-8	105-45-3	Eye Irrit. 2
methyl acrylamidoglycolate (containing ≥ 0,1 % acrylamide) MAGME(R) 200 MONOMER	403-230-3	77402-05-2	Carc. 1B; Muta. 1B; Skin Corr. 1B; Skin Sens. 1
methyl acrylamidomethoxyacetate (containing ≥ 0,1 % acrylamid) MAGME 100 MONOMEER	401-890-7	77402-03-0	Carc. 1B; Muta. 1B; Acute Tox. 4; Eye Irrit. 2
methyl acrylate; methyl propenoate	202-500-6	96-33-3	Flam. Liq. 2; Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
methyl chloroacetate	202-501-1	96-34-4	Flam. Liq. 3; Acute Tox. 3; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
methyl chloroformate	201-187-3	79-22-1	Flam. Liq. 2; Acute Tox. 2; Acute Tox. 4; Skin Corr. 1B
methyl formate	203-481-7	107-31-3	Flam. Liq. 1; Acute Tox. 4; Eye Irrit. 2; STOT SE 3
methyl iodide; iodomethane	200-819-5	74-88-4	Carc. 2; Acute Tox. 4; Acute Tox. 3; STOT SE 3; Skin Irrit. 2
methyl isocyanate	210-866-3	624-83-9	Flam. Liq. 2; Repr. 2; Acute Tox. 2; Acute Tox. 3; Resp. Sens. 1; Skin Sens. 1; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
methyl isothiocyanate	209-132-5	556-61-6	Acute Tox. 3; Skin Corr. 1B; Skin Sens. 1
methyl methacrylate; methyl 2-methylprop-2-enoate; methyl 2-methylpropenoate	201-297-1	80-62-6	Flam. Liq. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
methyl N-[3-acetylamino)-4-(2-cyano-4-nitrophenylazo)phenyl]-N-[(1-methoxy)acetyl]glycinate FAT 40'489	413-040-2	149850-30-6	Skin Sens. 1
methyl neodecanamide	414-460-9	105726-67-8	Acute Tox. 4
methyl propionate	209-060-4	554-12-1	Flam. Liq. 2; Acute Tox. 4
methyl tetrahydro-2-furancarboxylate METHFAT	420-670-1	37443-42-8	Eye Dam. 1
methyl vinyl ether	203-475-4	107-25-5	Flam. Gas 1; Press. Gas
methyl α-((4,6-dimethoxypyrimidin-2-yl)ureidosulphonyl)-o-toluate F5384	401-340-6	83055-99-6	Skin Sens. 1
methyl-2,3,5,6-tetrachloro-4- pyridylsulphone;2,3,5,6-tetrachloro-4-(methylsulphonyl)pyridine	236-035-5	13108-52-6	Acute Tox. 4; Eye Irrit. 2; Skin Sens. 1
methyl-2-[(aminosulfonyl)methyl]benzoate N 5297	419-010-5	112941-26-1	Acute Tox. 4; Eye Irrit. 2
methyl-3-methoxyacrylate BETA-METHOXYACRYLSÄURE METHYLESTER	412-900-4	5788-17-0	Skin Sens. 1
methyl-5-nitrophenyl-guanidine	435-500-1	152460-07-6	Acute Tox. 4; Eye Irrit. 2; Skin Sens. 1
methyl-ONN-azoxymethyl acetate; methyl azoxy methyl acetate	209-765-7	592-62-1	Carc. 1B; Repr. 1B
methyl-phenylene diamine; diaminotoluene [technical product — reaction mass of 4-methyl-m-phenylene diamine (EC No 202-453-1) and 2-methyl-m-phenylene diamine (EC No 212-513-9)]	246-910-3	25376-45-8	Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 3; Acute Tox. 4; STOT RE 2; Eye Irrit. 2; Skin Sens. 1
methylcyclohexane	203-624-3	108-87-2	Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
methylene dithiocyanate	228-652-3	6317-18-6	Acute Tox. 2; Acute Tox. 3; Skin Corr. 1B; Skin Sens. 1
methylenediphenyl diisocyanate	247-714-0	26447-40-5	Carc. 2; Acute Tox. 4; STOT RE 2; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1; Skin Sens. 1
methylethylketone peroxide trimer	429-320-2	24748-23-0	Org. Perox. B; Asp. Tox. 1; Skin Irrit. 2; Skin Sens. 1
methylhydrazine	200-471-4	60-34-4	Carc. 1B
methylmercuric chloride	204-064-2	115-09-3	Carc. 2; Repr. 1A; Lact.; Acute Tox. 2; STOT RE 1
methyltriphenylphosphonium chloride METHYL-TPP-CHLORID; MTPP-CHLORID	418-400-2	1031-15-8	Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1
metolcarb (ISO); m-tolyl methylcarbamate; MTMC	214-446-0	1129-41-5	Acute Tox. 4
metosulam (ISO); N-(2,6-dichloro-3-methylphenyl)-5,7-dimethoxy[1,2,4]triazolo[1,5-a] pyrimidine-2-sulfonamide	410-240-1	139528-85-1	Carc. 2; STOT RE 2
metribuzin (ISO); 4-amino-6-tert-butyl-3-methylthio-1,2,4-triazin-5(4H)-one; 4-amino-4,5-dihydro-6-(1,1-dimethylethyl)-3-methylthio-1,2,4-triazin-5-one	244-209-7	21087-64-9	Acute Tox. 4
mevinphos (ISO); 2-methoxycarbonyl-1-methylvinyl dimethyl phosphate	232-095-1	7786-34-7	Acute Tox. 1; Acute Tox. 2
mexacarbate (ISO); 3,5-dimethyl-4-dimethylaminophenyl N-methylcarbamate	206-249-3	315-18-4	Acute Tox. 2; Acute Tox. 4
Microsporum spp.	-	-		F Fungi
milbemectin (ISO) [reaction mass of milbemycin A3 (CAS No 51596-10-2) and milbemycin A4 (CAS No 51596-11-3) (30:70)]	-	-	Acute Tox. 4
Milkers' node virus	-	-		V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
millerite	-	1314-04-1	Carc. 1A; Muta. 2; STOT RE 1; Skin Sens. 1
Mineral wool, with the exception of those specified elsewhere in this Annex [Man-made vitreous (silicate) fibres with random orientation with alkaline oxide and alkali earth oxide (Na2O+K2O+CaO+MgO+BaO) content greater than 18 % by weight] show/hide Glass Wool EC / List no: - \| CAS no: 308066-92-4 Glass, oxide, chemicals This category encompasses the various chemical substances manufactured in the production of inorganic glasses. For purposes of this category, 'glass' is defined as an amorfous, inorganic, transparent, translucent or opaque material traditionally formed by fusion of sources of silica with a flux, such as an alkali-metal carbonate, boron oxide, etc. and a stabilizer, into a mass which is cooled to a rigid condition without crystallization in the case of transparent or liquid-phase separated glass or with controlled crystallization in the case of glass-ceramics. The category consists of the various chemical substances, other than by-products or impurities, which are formed during the production of various glasses and concurrently incorporated into a glass mixture. All glasses contain one or more of these substances, but few, if any, contain all of them. The elements listed below are principally present as components of oxide systems but some may also be present as halides or chalcogenides, in multiple oxidation states, or in more complex compounds. Trace amounts of other oxides or chemical compounds may be present. Oxides of the first seven elements listed* comprise more than 95 percent, by weight, of the glass produced. @Aluminium@Lead@Boron@Lithium@Calcium@Manganese@Magnesium@Molybdenum@Potassium@Neodymium@Silicon@Nickel@Sodium*@Niobium@Antimony@Nitrogen@Arsenic@Phosphorus@Barium@Praseodymium@Bismuth@Rubidium@Cadmium@Selenium@Carbon@Silver@Cerium@Strontium@Cesium@Sulfur@Chromium@Tellurium@Cobalt@Tin@Copper@Titanium@Germanium@Tungsten@Gold@Uranium@Holmium@Vanadium@Iron@Zinc@Lanthanum@Zirconium EC / List no: 266-046-0 \| CAS no: 65997-17-3	-	-	Carc. 2
mipafox (ISO); N,N'-di-isopropylphosphorodiamidic fluoride	206-742-3	371-86-8	STOT SE 1
mix-cresol	215-293-2	1319-77-3	Acute Tox. 3; Skin Corr. 1B
mixed linear and branched C14-15 alcohols ethoxylated, reaction product with epichlorohydrin NUPORE G45-10	420-480-9	158570-99-1	Skin Irrit. 2; Skin Sens. 1
molinate (ISO);S-ethyl 1-perhydroazepinecarbothioate; S-ethyl perhydroazepine-1-carbothioate	218-661-0	2212-67-1	Carc. 2; Repr. 2; Acute Tox. 4; STOT RE 2; Skin Sens. 1
molybdenum nickel hydroxide oxide phosphate	268-585-7	68130-36-9	Carc. 1A; STOT RE 1; Resp. Sens. 1; Skin Sens. 1
molybdenum nickel oxide	-	12673-58-4	Carc. 1A; STOT RE 1; Skin Sens. 1
molybdenum nickel tetraoxide	238-034-5	14177-55-0	Carc. 1A; STOT RE 1; Skin Sens. 1
molybdenum trioxide	215-204-7	1313-27-5	Carc. 2; Eye Irrit. 2; STOT SE 3
Monkeypox virus	-	-		V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
mono-2-[2-(4-dibenzo[b, f][1,4]thiazepin-11-yl)piperazinium-1-yl]ethoxy)ethanol trans-butenedioate ICI204636 HYDROGEN FUMARATE	415-180-1	773058-82-5	Acute Tox. 4; Eye Dam. 1
mono-methylamine;mono-methylamine ... %	200-820-0	74-89-5	Flam. Gas 1; Press. Gas; Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
mono-methylamine;mono-methylamine ... %	200-820-0	74-89-5	Flam. Liq. 1; Acute Tox. 4; Skin Corr. 1B
mono[2-(dimethylamino)ethyl]monohydrogen-2-(hexadec-2-enyl)butanedioate and/or mono[2-(dimethylamino)ethyl]monohydrogen-3-(hexadec-2-enyl)butanedioate Z-22	415-880-5	779343-34-9	Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
monoalkyl or monoaryl or monoalkyaryl esters of methacrylic acid with the exception of those specified elsewhere in this Annex	-	-	Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
monoalkylor monoaryl or monoalkylaryl esters of acrylic acid with the exception of those specified elsewhere in this Annex	-	-	Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
monobenzone; 4-hydroxyphenyl benzyl ether; hydroquinone monobenzyl ether	203-083-3	103-16-2	Eye Irrit. 2; Skin Sens. 1
monocrotophos (ISO); dimethyl-1-methyl-2-(methylcarbamoyl)vinyl phosphate	230-042-7	6923-22-4	Muta. 2; Acute Tox. 2; Acute Tox. 3
monolinuron (ISO); 3-(4-chlorophenyl)-1-methoxy-1-methylurea	217-129-5	1746-81-2	Acute Tox. 4; STOT RE 2
monosodium 3-cyano-5-fluoro-6-hydroxypyridine-2-olate	429-570-2	213990-58-0	Skin Sens. 1
monuron (ISO); 3-(4-chlorophenyl)-1,1-dimethylurea	205-766-1	150-68-5	Carc. 2; Acute Tox. 4
Mopeia virus	-	-		V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
morfamquat (ISO); 1,1'-bis(3,5-dimethylmorpholinocarbonylmethyl)-4,4'-bipyridilium ion	-	7411-47-4	Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
morfamquat dichloride	225-062-8	4636-83-3	Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
morfamquat sulfate	-	29873-36-7	Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
Morganella morganii	-	-		B Bacteria and similar species
morpholine	203-815-1	110-91-8	Flam. Liq. 3; Acute Tox. 4; Skin Corr. 1B
morpholine-4-carbonyl chloride	239-213-0	15159-40-7	Carc. 2; Eye Irrit. 2; Skin Irrit. 2
morphothion (ISO); O, O-dimethyl-S-(morpholinocarbonylmethyl) phosphorodithioate	205-628-0	144-41-2	Acute Tox. 3
Mucambo virus	-	-		V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
Mumps virus	-	-		V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
muscalure; cis-tricos-9-ene	248-505-7	27519-02-4	Skin Sens. 1B
musk ketone; 3,5-dinitro-2,6-dimethyl-4-tert-butylacetophenone; 4'-tert-butyl-2', 6'-dimethyl-3',; 5'-dinitroacetophenone	201-328-9	81-14-1	Carc. 2
musk xylene; 5-tert-butyl-2,4,6-trinitro-m-xylene	201-329-4	81-15-2	Expl. 1.1; Carc. 2		yes
myclobutanil(ISO);2-(4-chlorophenyl)-2-(1H-1,2,4- triazol-1-ylmethyl)hexanenitrile SYSTHANE TECHNICAL	410-400-0	88671-89-0	Repr. 2; Acute Tox. 4; Eye Irrit. 2
Mycobacterium africanum	-	-		B Bacteria and similar species
Mycobacterium avium/intracellulare	-	-		B Bacteria and similar species
Mycobacterium bovis (except BCG strain)	-	-		B Bacteria and similar species
Mycobacterium chelonae	-	-		B Bacteria and similar species
Mycobacterium fortuitum	-	-		B Bacteria and similar species
Mycobacterium kansasii	-	-		B Bacteria and similar species
Mycobacterium leprae	-	-		B Bacteria and similar species
Mycobacterium malmoense	-	-		B Bacteria and similar species
Mycobacterium marinum	-	-		B Bacteria and similar species
Mycobacterium microti	-	-		B Bacteria and similar species
Mycobacterium paratuberculosis	-	-		B Bacteria and similar species
Mycobacterium scrofulaceum	-	-		B Bacteria and similar species
Mycobacterium simiae	-	-		B Bacteria and similar species
Mycobacterium szulgai	-	-		B Bacteria and similar species
Mycobacterium tuberculosis	-	-		B Bacteria and similar species
Mycobacterium ulcerans	-	-		B Bacteria and similar species
Mycobacterium xenopi	-	-		B Bacteria and similar species
Mycoplasma caviae	-	-		B Bacteria and similar species
Mycoplasma hominis	-	-		B Bacteria and similar species
Mycoplasma pneumoniae	-	-		B Bacteria and similar species
N'-(1,3-dimethylbutylidene)-3-hydroxy-2-naphthohydrazide	435-860-1	214417-91-1	Skin Sens. 1
N, N''-(methylenedi-4,1-phenylene)bis[N'-(4-methylphenyl)urea]	429-380-1	133336-92-2	Skin Sens. 1
N, N''-(methylenedi-4,1-phenylene)bis[N'-octyl]urea	445-760-8	-	Eye Dam. 1; Resp. Sens. 1
N, N',N''-tris(2-methyl-2,3-epoxypropyl)-perhydro-2,4,6-oxo-1,3,5-triazine	435-010-8	26157-73-3	Muta. 2
N, N'-(2,2-dimethylpropylidene)hexamethylenediamine LUPRAGEN VP 9159	401-660-6	1000-78-8	Skin Irrit. 2; Skin Sens. 1
N, N'-bis(trifluoroacetyl)-S, S'-bis-L-homocysteine BMS 208143-01; BTHC	429-670-6	105996-54-1	Eye Dam. 1; Skin Sens. 1
N, N'-diphenyl-p-phenylenediamine; N, N'-diphenyl-1,4-benzenediamine	200-806-4	74-31-7	Skin Sens. 1
N, N'-ethylenebis(vinylsulfonylacetamide) H-603	404-790-1	66710-66-5	Eye Dam. 1; Skin Sens. 1
N, N,N',N'-tetramethyl-3,3'-(propylenebis(iminocarbonyl-4,1-phenylenazo(1,6-dihydro-2-hydroxy-4-methyl-6-oxopyridine-3,1-diyl)))di(propylammonium) dilactate CARTASOL BRILLIANT YELLOW K-6G; CARTASOL BRILLIANT YELLOW K-6G CONC.; GIALLO BRILLANTE CARTASOL K-6G CONC.; JAUNE BRILLANT CARTASOL K-RWA 3904; RWA 3904	403-340-1	164578-09-0	Eye Dam. 1
N, N,N',N'-tetramethyl-p-phenylenediamine	202-831-6	100-22-1	Acute Tox. 4
N, N,N',N'-tetramethyldithiobis(ethylene)diamine dihydrochloride AF-172; FPC 114	405-300-9	17339-60-5	Acute Tox. 4; Eye Irrit. 2; Skin Sens. 1
N, N,N',N'-tetramethylethylenediamine	203-744-6	110-18-9	Flam. Liq. 2; Acute Tox. 4; Skin Corr. 1B
N, N-(dimethylamino)thioacetamide hydrochloride	435-470-1	27366-72-9	Repr. 1B
N, N-bis(2-(p-toluenesulfonyloxy)ethyl)-p-toluenesulfonamide DIETHANOLAMIN-TRITOSYLAT	412-920-3	16695-22-0	Skin Sens. 1
N, N-bis(2-ethylhexyl)-((1,2,4- triazol-1-yl)methyl)amine CM 23-376; REOMET 30	401-280-0	91273-04-0	Skin Corr. 1B; Skin Sens. 1
N, N-bis(3-aminopropyl)methylamine	203-336-8	105-83-9	Acute Tox. 3; Acute Tox. 4; Skin Corr. 1B
N, N-bis(trimethylsilyl)aminopropylmethyldiethoxysilane	445-890-5	201290-01-9	Acute Tox. 4; Skin Sens. 1
N, N-dibutyl-(2,5-dihydro-5-thioxo-1H-tetrazol-1-yl)acetamide	418-290-6	168612-06-4	Eye Irrit. 2; Skin Sens. 1
N, N-diethyl-N',N'-dimethylpropan-1,3-diyl-diamine DDPD	406-610-7	62478-82-4	Flam. Liq. 3; Acute Tox. 4; STOT RE 2; Skin Corr. 1A
N, N-dimethyl-2-(3-(4-chloro phenyl)-4,5-dihydropyrazol-1- ylphenylsulphonyl)ethylamine HOSTALUX VP 3481	401-410-6	10357-99-0	STOT RE 2; Skin Sens. 1
N, N-dimethylanilinium tetrakis(pentafluorophenyl)borate B1; N,N-DIMETHYLANILINUM TETRAKIS(PENTAFLUOROPHENYL)BORATE; TÉTRAKIS(PENTAFLUOROPHÉNYL)BORATE DE N,N-DIMÉTHYLANILINIUM	422-050-6	118612-00-3	Carc. 2; Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1
N, N-dimethylformamide; dimethyl formamide	200-679-5	68-12-2	Repr. 1B; Acute Tox. 4; Eye Irrit. 2		yes
N, N-hydrazinodiacetic acid F.H.D.A.	403-510-5	19247-05-3	Acute Tox. 3; STOT RE 2; Skin Sens. 1
N,N'-bis(2,2,6,6-tetramethyl-4-piperidyl)isophthalamide NYLOSTAB S-EED; NYSEED	419-710-0	42774-15-2	Acute Tox. 4; Eye Irrit. 2
N,N'-bis{6-chloro-4-[6-(4-vinylsulfonylphenylazo)-2,7-disulfonicacid-5-hydroxynapht-4-ylamino]-1,3,5-triazin-2-yl}-N-(2-hydroxyethyl)ethane-1,2-diamine, sodium salt RED REN 363	419-500-9	171599-85-2	Eye Dam. 1; Skin Sens. 1
N,N'-diacetylbenzidine	210-338-2	613-35-4	Carc. 1B; Muta. 2; Acute Tox. 4
N,N'-dihexadecyl-N,N'-bis(2-hydroxyethyl)propanediamide QUESTAMIDE H	422-560-9	149591-38-8	Repr. 2; Eye Irrit. 2
N,N'-dimethylbenzidine	-	2810-74-4	Acute Tox. 4
N,N'-methylenedimorpholine; N,N'-methylenebismorpholine [formaldehyde released from N,N'-methylenebismorpholine]; [MBM]	227-062-3	5625-90-1	Carc. 1B; Muta. 2; Acute Tox. 4; STOT RE 2; Skin Corr. 1B; Skin Sens. 1; Eye Dam. 1
N,N'—1,6-hexanediylbis(N-(2,2,6,6-tetramethyl-piperidin-4-yl)-formamide LICHTSCHUTZMITTEL 1736	413-610-0	124172-53-8	Eye Irrit. 2
N,N,N',N'-tetraglycidyl-4,4'-diamino-3,3'-diethyldiphenylmethane PFMT 1848	410-060-3	130728-76-6	Muta. 2; Skin Sens. 1
N,N,N',N'-tetramethyl-4,4'-methylendianiline	202-959-2	101-61-1	Carc. 1B		yes
N,N,N,N-tetrakis(4,6-bis(butyl- (N-methyl-2,2,6,6-tetramethyl piperidin-4-yl)amino)triazin-2- yl)-4,7-diazadecane-1,10- diamine CHIMASSORB 119; LOWILITE 19	401-990-0	106990-43-6	Skin Sens. 1
N,N,N-trimethylanilinium chloride	205-319-0	138-24-9	Acute Tox. 3
N,N-bis(cocoyl-2-oxypropyl)-N,N-dibutylammonium bromide	431-530-4	1380226-29-8	Skin Corr. 1A; Skin Sens. 1
N,N-diethyl-m-toluamide; deet	205-149-7	134-62-3	Acute Tox. 4; Eye Irrit. 2; Skin Irrit. 2
N,N-diethylaniline	202-088-8	91-66-7	Acute Tox. 3; STOT RE 2
N,N-dimethyl-m-toluidine	204-495-6	121-72-2	Acute Tox. 3; STOT RE 2
N,N-dimethyl-o-toluidine	210-199-8	609-72-3	Acute Tox. 3; STOT RE 2
N,N-dimethyl-p-toluidine	202-805-4	99-97-8	Acute Tox. 3; STOT RE 2
N,N-dimethylacetamide	204-826-4	127-19-5	Repr. 1B; Acute Tox. 4		yes
N,N-dimethylaniline	204-493-5	121-69-7	Carc. 2; Acute Tox. 3
N,N-dimethylbenzene-1,3-diamine	220-623-3	2836-04-6	Acute Tox. 3
N,N-dimethylhydrazine	200-316-0	57-14-7	Flam. Liq. 2; Carc. 1B; Acute Tox. 3; Skin Corr. 1B
N-(1,3-dimethylbutyl)-N'-(phenyl)-1,4-benzoquinonediimine	429-640-2	52870-46-9	Eye Irrit. 2
N-(2',6'-dimethylphenyl)-2-piperidinecarboxamide hydrochloride PPX-HCL	417-950-0	65797-42-4	Acute Tox. 4
N-(2,2,6,6-tetramethyl-1-oxylpiperidin-4-yl)acetamide; (4-acetamido-2,2,6,6-tetra; methyl-1-piperidinyl)oxidanyl	423-840-3	14691-89-5	Acute Tox. 4
N-(2-(4-amino-N-ethyl-m-toluidino)ethyl)methanesulphonamide sesquisulphate; 4-(N-ethyl-N-2-methanesulphonylaminoethyl)-2-methylphenylenediamine sesquisulphate monohydrate	247-161-5	25646-71-3	Acute Tox. 4; Skin Sens. 1
N-(2-(6-ethyl-7-(4-methylphenoxy)-1H-pyrazolo[1,5-b][1,2,4]triazol-2-yl)propyl)-2-octadecyloxybenzamide UM-229	407-070-5	142859-67-4	Skin Sens. 1
N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide	425-650-6	171887-03-9	Acute Tox. 4; Eye Dam. 1; Skin Sens. 1
N-(4-(3-(4-cyanophenyl)ureido)-3-hydroxyphenyl)-2-(2,4-di-tert-pentylphenoxy)octanamide UC-129	403-790-9	108673-51-4	Skin Sens. 1
N-(5-chloro-3-((4-(diethylamino)-2-methylphenyl)imino-4-methyl-6-oxo-1,4-cyclohexadien-1-yl)benzamide TSD-40	413-200-1	129604-78-0	Skin Sens. 1
N-(dichlorofluoromethylthio)phthalimide; N-(fluorodichloromethylthio)phthalimide	211-952-3	719-96-0	Skin Irrit. 2
N-(hydroxymethyl)acrylamide; methylolacrylamide; [NMA]	213-103-2	924-42-5	Carc. 1B; Muta. 1B; STOT RE 1
N-(n-octyl)-2-pyrrolidone NOP; SURFADONE LP-100 SURFACTANT	403-700-8	2687-94-7	Skin Corr. 1B
N-2-naphthylaniline; N-phenyl-2-naphthylamine	205-223-9	135-88-6	Carc. 2; Eye Irrit. 2; Skin Irrit. 2; Skin Sens. 1
N-[(benzotriazole-1-yl)methyl)]4-carboxy-benzenesulfonamide BTAD	416-470-9	170292-97-4	Eye Irrit. 2
N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanyl-N-carboxyanhydride	430-360-8	84793-24-8	Eye Dam. 1; Skin Sens. 1
N-[2-(3-acetyl-5-nitrothiophen-2-ylazo)-5-diethylaminophenyl]acetamide DISPERSOL BLUE C-4G COLOUR; SUBSTANCE H87919	416-860-9	777891-21-1	Repr. 2; Skin Sens. 1
N-[2-hydroxy-3-(C12-16-alkyloxy)propyl]-N-methyl glycinate DS 100	415-060-7	1379678-87-1	Eye Dam. 1; Skin Sens. 1
N-[3-(1,1-dimethylethyl)-1H-pyrazol-5-yl]-N'-hydroxy-4-nitrobenzenecarboximidamide	423-530-8	152828-23-4	STOT RE 1; Acute Tox. 4
N-[3-[(2-acetyloxy)ethyl](phenyl-methyl)amino]-4-methoxyphenylacetamide BENZANILID-DISPERSE-INTERMEDIATE ZP 9955	411-590-8	70693-57-1	Skin Corr. 1B
N-[4-cyano-3-trifluoromethylphenyl]methacrylamide	427-880-2	90357-53-2	STOT RE 2
N-[6,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6-oxo-1H-purin-2-yl]acetamide	424-550-1	84245-12-5	Carc. 1B; Muta. 1B; Repr. 1B
N-amidino-N-methylglycine-2-oxopropionate	429-120-5	208535-04-0	Eye Dam. 1
N-benzyl-N-ethyl-(4-(5-nitro-benzo[c]isothiazol-3-ylazo)phenyl)amine	425-300-2	186450-73-7	Skin Sens. 1
n-butyl acetate	204-658-1	123-86-4	Flam. Liq. 3; STOT SE 3
n-butyl acrylate	205-480-7	141-32-2	Flam. Liq. 3; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
n-butyl methacrylate	202-615-1	97-88-1	Flam. Liq. 3; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
n-butyl propionate	209-669-5	590-01-2	Flam. Liq. 3
N-butyl-2-(4-morpholinylcarbonyl)benzamide EP 389	407-730-2	104958-67-0	Eye Irrit. 2; Skin Sens. 1
N-butyl-3-(2-chloro-4-nitrophenylhydrazono)-1-cyano-2-methylprop-1-ene-1,3-dicarboximide DISPERSOL YELLOW XF	407-970-8	75511-91-0	Skin Sens. 1
n-butyronitrile	203-700-6	109-74-0	Flam. Liq. 2; Acute Tox. 3
N-carboxymethyliminobis(ethylenenitrilo)tetra (acetic acid)	200-652-8	67-43-6	Acute Tox. 4; STOT RE 2; Eye Irrit. 2
N-cyclohexyl-S, S-dioxo; benzo[b]tiophene-2-carboxamide PREVENTOL VP OC 3061	423-990-1	149118-66-1	Acute Tox. 4; Eye Dam. 1
N-cyclohexylbenzothiazole-2- sulphenamide	202-411-2	95-33-0	Skin Sens. 1
N-dodecyl-[3-(4-(dimethylamino)benzamido)-propyl]dimethylammonium tosylate DIMETHYLPAPAMIDOLAURDIMONIUM TOSYLATE	421-130-8	156679-41-3	Eye Dam. 1; Skin Sens. 1
N-ethyl-2-pyrrolidone; 1-ethylpyrrolidin-2-one	220-250-6	2687-91-4	Repr. 1B
N-ethyl-3-trimethoxysilyl-2-methyl-propanamine	437-720-3	227085-51-0	Eye Dam. 1
N-ethyl-N-methylpiperidinium iodide CATALYST 4017	407-780-5	4186-71-4	Acute Tox. 4
N-ethylaniline	203-135-5	103-69-5	Acute Tox. 3; STOT RE 2
N-hexadecyl(or octadecyl)-N-hexadecyl (or octadecyl)benzamide DTBA	401-980-6	-	Skin Irrit. 2; Skin Sens. 1
n-hexane	203-777-6	110-54-3	Flam. Liq. 2; Repr. 2; Asp. Tox. 1; STOT RE 2; Skin Irrit. 2; STOT SE 3
n-hexyllithium N-HEXYLLITHIUM	404-950-0	21369-64-2	Water-react. 1; Pyr. Sol. 1; Skin Corr. 1A
N-isopropyl-N'-phenyl-p-phenylenediamine	202-969-7	101-72-4	Acute Tox. 4; Skin Sens. 1

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EU-IMPLANTABLE_MEDICAL_DEVICES-ART_3_ANX_1

EU-IMPLANTABLE_MEDICAL_DEVICES-ART_3_ANX_1

Active Implantable Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 90/385/EEC on Active Implantable Medical Devices, 20 July 1990, amended by Directive 2007/47/EC, 21 September 2007

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Last updated 26 balandis 2024. Database contains 4753 unique substances/entries.

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