Substance Information

The REACH registered substance data and the C&L Inventory portal will be upgraded from the 9th November.

Please be aware there may be intermittent unavailability while work in ongoing. The per substance REACH registration status will be made available as soon as possible thereafter. Likewise the per substance indication of harmonised C&L, Seveso directive, or notified C&L regulatory context will be made available as soon as possible.

Please note that it may take a week or two to have everything fully in place, and please be aware in the meantime that the Registration status may be incorrect and the CLP regulatory context may be incompletely shown.

Substance Infocard


Methylenediphenyl diisocyanate (MDI) including the following specific isomers (See group members):

EC / List no.: -

CAS no.: -

Mol. Formula:

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Key datasets

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Regulatory context

Here you can find all of the regulations and regulatory lists in which this substance appears, according to the data available to ECHA. This substance has been found in the following regulatory activities (directly, or inheriting the regulatory context of a parent substance):

REACH - Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation
  • REACH Annex XVII. Substances for which certain uses are Restricted under REACH at EU level.
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Substance names and other identifiers

Regulatory process names
Methylenediphenyl diisocyanate (MDI) including the following specific isomers (See group members):
Restriction list
Other names
Restriction list
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Group members

This entry / group of substance has the following member substances:

Name EC / List no. CAS no. Association
Methylenediphenyl diisocyanate 247-714-0 26447-40-5 Expert judgement
4,4'-methylenediphenyl diisocyanate 202-966-0 101-68-8 Expert judgement
o-(p-isocyanatobenzyl)phenyl isocyanate 227-534-9 5873-54-1 Expert judgement
2,2'-methylenediphenyl diisocyanate 219-799-4 2536-05-2 Expert judgement

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