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EC number: 233-634-3
CAS number: 10287-53-3
Table 1: Ocular reactions elicited by the test material
Rabbit number and sex
Region of eye
Day after instillation
A study was conducted to investigate the potential of the test material
to cause eye irritation in accordance with the standardised guidelines
OECD 405 and EU Test Method B.5.
Three male albino rabbits (New Zealand White strain) were treated with
the instillation of 33 mg of the test material, equivalent to a volume
of 0.1 mL, into the lower everted lid of one eye. The eyelids were held
together for one second before releasing; the contralateral eye remained
untreated and served as a control. Eyes of the test animals were
examined after 1 hour and 1, 2, 3, 4 and 7 days post treatment.
No corneal damage or iridial inflammation was observed in any of the
animals. Obvious swelling with partial eversion of the eyelids was seen
in one animal one hour after instillation only. Transient, mild
conjunctival irritation was seen in the two remaining animals. The eyes
were normal two days after instillation.
The overall mean scores for the three animals from the 24, 48 and 72
hour observations for the cornea, iris, redness and chemosis parameters
were 0, 0, 0.33 and 0.11, respectively.
Under the conditions of this study, the test material has been
determined to be not irritating.
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