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EC number: 233-634-3
CAS number: 10287-53-3
Correction factor for differences in respiratory volume (rat/workers): 1/0.38
Correction factor for light activity at work : 6.7/10
Correction factor for difference between human and experimental exposure conditions : 7/5 (In the study, animals were exposed 7 days per week, and workers work 5 days per week).
Oral absorption = 100 % (see section 7.1 Toxicokinetics)
Inhalation absorption = 100% (see section 7.1 Toxicokinetics)
NOAEC = NOAEL x (1/0.38) x (6.7/10) x 7/5= 50 x (1/0.38) x (6.7/10) x 7/5 = 123.4 mg/m3
Based on the TK assessment, a dermal absorption of 10% was used.
Dermal NOAEL = oral NOAEL x 100/10 x 7/5= 50 x 100/10 x 7/5 = 700 mg/kg bw/day
Two oral NOAELs following an exposure of at least 28 days are available in this dossier : a NOAEL of 6 mg/kg/day in the 28-day repeated toxicity study, and a NOAEL of 50 mg/kg/day obtained fin the reproduction screening (OECD 421) study. The highest value (e.g. 50 mg/kg/day) was selected as point of departure for DNEL derivation.
Correction factor for differences in respiratory volume (rat/general population): 1/1.15
NOAEC = NOAEL x (1/1.15) = 50 x (1/1.15) = 43.5 mg/m3
Dermal NOAEL = oral NOAEL x 100/10 = 50 x 100/10 = 500 mg/kg bw/day
The oral absorption is considered to be similar in rat and human.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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