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EC number: 233-634-3
CAS number: 10287-53-3
Table 2: HPLC Determination of Log10 Koc
for the test material
Standard Run A (t0 = 2.683 minutes)
Sample A (t0 = 2.680 minutes)
Sample B (t0 = 2.678 minutes)
Standard Run B (t0 = 2.678 minutes)
Linear regression (based on mean of standard runs A and
B): log10 Koc = 4.73 log10 k’ + 3.78
The soil adsorption potential of the test material was estimated in
accordance with the standardised guidelines OECD 121 and EU Method C.19
under GLP conditions using the HPLC Method.
HPLC was performed on commercially available analytical columns packed
with a solid phase containing a moderately polar stationary phase with
lipophilic and polar moieties. The adsorption coefficient is deduced
from the capacity factor (k’). A solution of test material
(approximately 16 mg/L in HPLC mobile phase, and also containing
internal deadtime standard) was prepared and chromatographed in
duplicate, bracketed by samples of the reference mixture. A calibration
plot of log10 k’ versus log10 Koc was constructed for the reference
standards. The logarithm of the capacity factor for the test material
was then calculated and the log10 Koc value was determined by
Under the conditions of this study, the test material was determined to
have a log10 Koc value of 2.8 (equivalent to a Koc value of 560).
The soil adsorption of the test material was estimated in accordance
with the standardised guidelines OECD 121 and EU Method C.19 under GLP
conditions using the HPLC Method. The study was awarded a reliability
score of 1 in accordance with the criteria set forth by Klimisch et al.
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