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Long-term toxicity to fish

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Reference
Endpoint:
fish early-life stage toxicity
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:

Description of key information

The toxicity of the test material to fish was investigated in a GLP study which was conducted in accordance with standardised guideline OECD 203. Due to the low water solubility of the test material in water, analysis of the test media during the study showed significant declines in measured test material concentrations and at 24 h had declined to less than the limit of quantification. Analysis of the freshly prepared test preparations at 0 and 72 hours showed measured test concentrations to range from less than the limit of quantification (0.059 mg/L) to 3.0 mg/L. After 96 hours, 100 % mortality was observed in the highest test material concentration with sub-lethal effects of exposure observed at test concentrations above 1.2 mg/L. As the test material is already definitively classified for chronic aquatic toxicity at category 2 and a robust conclusion to be reached in the existing risk assessment long-term test on fish it was not considered scientifically necessary. In addition the difficulties maintaining the levels of test material for the duration of the test and analysing the test material, suggest that the long-term toxicity testing on fish is unlikely to be technically feasible.

Key value for chemical safety assessment

Additional information