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EC number: 233-634-3
CAS number: 10287-53-3
Table 2: HPLC Determination of Log10 Pow for the test
Standard Run A (t0 = 1.362 minutes)
Sample A (t0 = 1.364 minutes)
Sample B (t0 = 1.362 minutes)
Standard Run B (t0 = 1.363 minutes)
Linear regression (based on mean of standard runs A and
B): log10 Pow = 3.20 log10 k’ + 3.00
The partition coefficient of the test material was determined in
accordance with the standardised guidelines OECD 117 and EU Method A.8
under GLP conditions using high performance liquid chromatography.
In order to correlate the measured capacity factor (k’) of the test
material with its Pow, six reference materials were selected from a list
of recommended compounds. These reference compounds were selected to
have log10 Pow values between 1.0 and 6.2. A solution of test material
(approximately 16 mg/L in HPLC mobile phase, and also containing
internal deadtime standard) was prepared and chromatographed in
duplicate, bracketed by samples of the reference mixture. As the test
material contains an amine functional group, the test was conducted
using mobile phase buffered at pH 10. The column temperature was 25 °C.
Under the conditions of this study the test material was found to have a
log10 Pow value of 3.2 (equivalent to a Pow value of 1500).
The partition coefficient of the test material was determined in accordance with the standardised guidelines OECD 117 and EU Method A.8 under GLP conditions using high performance liquid chromatography. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
Under the conditions of this study the test material was found to have a log10 Pow value of 3.2 (equivalent to a Pow value of 1500).
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