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EC number: 233-634-3
CAS number: 10287-53-3
Table 1: Signs of reaction to treatment observed
No. of animals in group of 5 showing signs at 2000 mg/kg
Pallor of extremities
Table 2: Individual bodyweights
Bodyweight (g) at Day
The acute oral toxicity of the test material was investigated in
accordance with the standardised guidelines OECD 401 and EU Method B1.
A group of 5 male and 5 female rats were exposed to the test material in
corn oil at a limit dose of 2000 mg/kg bw. Fasted animals were dosed via
a syringe and plastic catheter. All animals were observed for 14 days
after dosing before being terminated on day 15 and subjected to
macroscopic examination at necropsy.
There were no cases of mortality during the study. Signs of reaction to
treatment observed shortly after dosing in all animals were
pilo-erection, abnormal body carriage (hunched posture), abnormal gait
(waddling), lethargy and pallor of extremities. Recovery, as judged by
external appearance and behaviour, was advanced by Day 2 and complete by
Day 3. Terminal autopsy findings were normal.
Under the conditions of this study the acute lethal oral dose was found
to be greater than 2000 mg/kg bodyweight.
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