Registration Dossier
Registration Dossier
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EC number: 233-634-3 | CAS number: 10287-53-3
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
The ready biodegradability of the test material was determined in accordance with the standardised guidelines OECD 301B, EU Method C.4-C and US EPA OCSPP 835.3110 under GLP conditions using the CO2 evolution test. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997). The toxicity control attained 64 % biodegradation after 14 days and 28 days thereby confirming that the test material did not exhibit an inhibitory effect on the sewage treatment micro-organisms used in the test. Sodium benzoate attained 79 % biodegradation after 14 days and 82 % biodegradation after 28 days thereby confirming the suitability of the inoculum and test conditions. Under the conditions of the study the test material attained 40 % biodegradation after 28 days and therefore cannot be considered readily biodegradable.
In addition, as the substance is not considered readily biodegradable, the likely aerobic biodegradation products of the registered substance were identified via the in silico method EAWAG-BBD Pathway Prediction System. A total of 14 compounds (including the parent substance) were identified. Their P and B properties were also assessed via the use of the in silico tool US EPA EPISUITE (KOWWIN, BIOWIN, BCFBAF); the results indicate that none of the identified compounds are likely to fulfill PBT or vPvB criteria. Consequently, no further biodegradation studies are proposed.
Key value for chemical safety assessment
- Biodegradation in water:
- not biodegradable
- Type of water:
- freshwater
Additional information
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