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EC number: 233-634-3
CAS number: 10287-53-3
A study was conducted to investigate the acute dermal toxicity of the
test material in accordance with the standardised guidelines OECD 402
and EU Method B.3.
Five male and 5 female rats received a dermal administration of the test
material (as a paste made with distilled water) at a limit dose of 2000
mg/kg bodyweight. Gauze used to cover the treated area was held in place
with an impermeable dressing encircled firmly around the trunk. The
animals were exposed to the test material for 24 hours before it was
washed off with warm water and blotted with absorbent paper. All animals
were observed for 14 days after dosing before being terminated on day 15
and subjected to macroscopic examination at necropsy.
All animals survived to study termination and there were no clinical
signs of toxicity noted throughout the 14-day study period. Slightly low
bodyweight gains were recorded for one male and three females on Day 15.
All other animals achieved anticipated bodyweight gains throughout the
study. There were no gross pathological findings observed in any animals
in the terminal autopsy.
Under the conditions of this study, the LD50 has been determined to be
greater than 2000 mg/kg bodyweight.
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