Ethyl 4-dimethylaminobenzoate

Stability: thermal, sunlight, metals

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

thermal stability

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

25 July 1990 to 26 July 1990

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 113 (Screening Test for Thermal Stability and Stability in Air)

GLP compliance:

not specified

Test substance thermally stable:

yes

Key result

Operating temp.:

200 °C

Sublimation:

no

Transformation products:

no

- Experiment 1: The temperature of the test material reached 190 °C within 100 minutes and then gradually increased to 197 °C over the next hour. No exothermic reaction was observed at any time although some endotherms, due to physical changes, occurred.

The pre-heated sample weighed 10.0 grams and the assay was 98.4 %. The post-heated sample weighed 9.25 grams and the assay was 99.5 %.

 

- Experiment 2: The temperature of the material reached 195 °C within 20 minutes and then gradually rose to 200 °C over the next hour. No exothermic reactions were observed at any time.

The pre-heated sample weighed 10.0 grams and the assay was 98.4 %. The post-heated sample weighed 7.35 grams and the assay was 96.1 %.

 

The results show that the test material does not decompose when heated to 200 °C for up to 18 hours.

Conclusions:

Under the conditions of this study the test material does not decompose when heated to 200 °C for 18 hours.

Executive summary:

The thermal stability of the test material investigated using methodology broadly equivalent to the standardised guideline OECD 113.

Two different experimental methods were performed, dynamic heating and fixed temperature.

In method 1, 10 grams of the test material was weighed into a small thermal stability tube which was then placed in the oven. The oven was switched on and the temperature allowed to rise at the rate of 2 °C/minute. When the oven temperature reached 200 °C it was held at that level for one hour.

In method 2, the oven was switched on and the temperature was allowed to rise to 200 °C.10 grams of the test material was weighed in a small thermal stability tube which was then placed in the heated oven for up to 18 hours.

In each experiment the temperatures of both the oven and test material were plotted on a dual-channel flat-bed recorder. At the end of each experiment, samples of the pre-heated and post-heated test material were assayed.

In Experiment 1, the temperature of the test material reached 190 °C within 100 minutes and then gradually increased to 197 °C over the next hour. No exothermic reaction was observed at any time although some endotherms, due to physical changes, occurred. The pre-heated sample weighed 10.0 grams and the assay was 98.4 %. The post-heated sample weighed 9.25 grams and the assay was 99.5 %.

 In Experiment 2, the temperature of the material reached 195 °C within 20 minutes and then gradually rose to 200 °C over the next hour. No exothermic reactions were observed at any time. The pre-heated sample weighed 10.0 grams and the assay was 98.4 %. The post-heated sample weighed 7.35 grams and the assay was 96.1 %.

Under the conditions of this study the test material does not decompose when heated to 200 °C for 18 hours.

Reference 2

Endpoint:

thermal stability

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

11 January 1991 to 14 January 1991

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 113 (Screening Test for Thermal Stability and Stability in Air)

GLP compliance:

not specified

Test substance thermally stable:

yes

Key result

Operating temp.:

250 °C

Sublimation:

no

Transformation products:

no

The temperature of the materials reached 240 °C within 30 minutes and then gradually increased to 245 °C. No exothermic reactions were observed at any time. The pre-heat and post-heat weights and assays are given in Table 1.

The results show that the test material does not decompose, exothermically or otherwise, when heated to 250 °C for up to 7 hours.

Thus, allowing a margin of 50 to 60 °C for scale up effects, both the pure and crude materials may be safely heated up to 190 to 200 °C.

 

Table 1: Pre- and Post-heat Weights and Assays

Sample		Weight (g)	Assay (%)
Pure material	Pre-heated	10.0	98.7
	Post-heated	9.30	99.6
Crude material	Pre-heated	10.0	98.4
	Post-heated	9.88	98.1

Conclusions:

Under the conditions of this study, the test material was shown not to decompose, exothermically or otherwise, when heated to 250 °C for up to 7 hours.

Executive summary:

The thermal stability of the test material in both pure and crude forms was investigated sing methodology broadly equivalent to the standardised guideline OECD 113.

10 grams of the test material was weighed into a small thermal stability tube, to which was attached a glass-tube approximately 50 cm long to act as a condenser. The thermal stability tube was placed in an oven which was then switched on to allow the temperature to rise rapidly to 250 °C. The temperature was held at that level for at least 6 hours.

The temperature of both the oven and the test material were plotted on a dual-channel flat-bed recorder. At the end of the experiment samples of the pre-heated and post-heated material were assayed.

The results show that the test material does not decompose, exothermically or otherwise, when heated to 250 °C for up to 7 hours.

Under the conditions of this study, the test material was shown not to decompose, exothermically or otherwise, when heated to 250 °C for up to 7 hours. Allowing a margin of 50 to 60 °C for sale-up effects the pure and crude test material may be safely heated up to the temperature of 190 to 200 °C.

Description of key information

- 18 Hour study: Under the conditions of this study the test material does not decompose when heated to 200 °C for 18 hours.

- 7 Hour study: Under the conditions of this study, the test material was shown not to decompose, exothermically or otherwise, when heated to 250 °C for up to 7 hours. Allowing a margin of 50 to 60 °C for sale-up effects the pure and crude test material may be safely heated up to the temperature of 190 to 200 °C.

Additional information

18 hour study

The thermal stability of the test material investigated using methodology broadly equivalent to the standardised guideline OECD 113. The study was awarded a reliability score of 2 in accordance with the criteria set forth by Klimisch et al. (1997).

Two different experimental methods were performed, dynamic heating and fixed temperature.

In method 1, 10 grams of the test material was weighed into a small thermal stability tube which was then placed in the oven. The oven was switched on and the temperature allowed to rise at the rate of 2 °C/minute. When the oven temperature reached 200 °C it was held at that level for one hour.

In method 2, the oven was switched on and the temperature was allowed to rise to 200 °C.10 grams of the test material was weighed in a small thermal stability tube which was then placed in the heated oven for up to 18 hours.

In each experiment the temperatures of both the oven and test material were plotted on a dual-channel flat-bed recorder. At the end of each experiment, samples of the pre-heated and post-heated test material were assayed.

In Experiment 1, the temperature of the test material reached 190 °C within 100 minutes and then gradually increased to 197 °C over the next hour. No exothermic reaction was observed at any time although some endotherms, due to physical changes, occurred. The pre-heated sample weighed 10.0 grams and the assay was 98.4 %. The post-heated sample weighed 9.25 grams and the assay was 99.5 %.

 In Experiment 2, the temperature of the material reached 195 °C within 20 minutes and then gradually rose to 200 °C over the next hour. No exothermic reactions were observed at any time. The pre-heated sample weighed 10.0 grams and the assay was 98.4 %. The post-heated sample weighed 7.35 grams and the assay was 96.1 %.

Under the conditions of this study the test material does not decompose when heated to 200 °C for 18 hours.

7 hour study

The thermal stability of the test material in both pure and crude forms was investigated sing methodology broadly equivalent to the standardised guideline OECD 113. The study was awarded a reliability score of 2 in accordance with the criteria set forth by Klimisch et al. (1997).

10 grams of the test material was weighed into a small thermal stability tube, to which was attached a glass-tube approximately 50 cm long to act as a condenser. The thermal stability tube was placed in an oven which was then switched on to allow the temperature to rise rapidly to 250 °C. The temperature was held at that level for at least 6 hours.

The temperature of both the oven and the test material were plotted on a dual-channel flat-bed recorder. At the end of the experiment samples of the pre-heated and post-heated material were assayed.

The results show that the test material does not decompose, exothermically or otherwise, when heated to 250 °C for up to 7 hours.

Under the conditions of this study, the test material was shown not to decompose, exothermically or otherwise, when heated to 250 °C for up to 7 hours. Allowing a margin of 50 to 60 °C for sale-up effects the pure and crude test material may be safely heated up to the temperature of 190 to 200 °C.