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EC number: 201-052-9
CAS number: 77-73-6
Summary of reproductive performance
Number of females
Dose Level (mg/kg/day)
Died during study
Litters with live foetuses
levels of 200, 300, 400 and 500 mg/kg/day were lethal to pregnant rats
when given from day 6 of gestation. Clinical signs included dried
material around nose and mouth, rough hair coat, lethargy, hunched
posture and ataxia. Maternal body weights were decreased in a
dose-related manner. All animals given 50 mg/kg/day survived to
termination of the study; all maternal bodyweights were significantly
lower than the controls during the treatment period. Only the control,
50 and 200 mg/kg/day groups had litters with live foetuses at necropsy
on gestation day 20. Foetal weight in the 200 mg/kg/day group was
significantly decreased but there was no similar effect at 50
mg/kg/day. The mean number of live foetuses was unaffected by treatment.
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