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EC number: 201-052-9
CAS number: 77-73-6
The acute dermal toxicity of
dicyclopentadiene 75% was assessed in a group of 5 male and 5 female
rats. 2.06 mL/kg body weight was applied to the shorn flank and held in
place with an occlusive dressing. Animals were observed at 1 and 4 hours
after dosing and then daily for 14 days. Clinical signs present on day 1
included vocalisation lasting up to 30 minutes (noted in all animals
after dosing), hunched posture, lethargy, piloerection, erythema and
oedema, . Isolated incidences of red/brown staining of snout and ptosis
were seen. All animals showed signs of eschar by day 3 which persisted
until days 10 or 12. All treatment sites appeared normal by the end of
study. All animals gained weight and there were no gross abnormalities
at necropsy. The acute dermal LD50 of dicyclopentadiene 75% in the rat
was greater than 2000 mg/kg body weight.
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